PubRank

Dafydd R Owen

Author PubWeight™ 9.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem 2012 1.55
2 PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains. Cancer Res 2013 1.53
3 TAFIa inhibitors in the treatment of thrombosis. Curr Opin Drug Discov Devel 2008 1.14
4 Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis. Bioorg Med Chem Lett 2009 1.04
5 Enantioselective catalytic intramolecular cyclopropanation using modified cinchona alkaloid organocatalysts. Angew Chem Int Ed Engl 2006 1.04
6 Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem 2007 0.90
7 Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors. Bioorg Med Chem Lett 2011 0.81
8 Corrigendum: The promise and peril of chemical probes. Nat Chem Biol 2015 0.79
9 Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5). J Med Chem 2010 0.76
10 Optimisation of a novel series of selective CNS penetrant CB(2) agonists. Bioorg Med Chem Lett 2011 0.75
11 Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. Bioorg Med Chem Lett 2009 0.75
12 Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one. Bioorg Med Chem Lett 2009 0.75