Published in Mol Psychiatry on April 16, 2013
Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies. Transl Psychiatry (2015) 1.49
The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins. Mol Psychiatry (2014) 0.90
Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation. PLoS One (2014) 0.85
Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein. Pharmacol Res Perspect (2014) 0.80
Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking. Elife (2016) 0.79
Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory. Mol Psychiatry (2016) 0.78
Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers. Sci Rep (2015) 0.77
ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration. Front Aging Neurosci (2015) 0.77
The Eight and a Half Year Journey of Undiagnosed AD: Gene Sequencing and Funding of Advanced Genetic Testing Has Led to Hope and New Beginnings. Front Endocrinol (Lausanne) (2017) 0.76
Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimers Dement (2016) 0.76
Role of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding. Cell Mol Life Sci (2016) 0.76
Microtubule stabilising peptides rescue tau phenotypes in-vivo. Sci Rep (2016) 0.75
Detection of Peptide-based nanoparticles in blood plasma by ELISA. PLoS One (2015) 0.75
ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy. Mol Psychiatry (2017) 0.75
Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders. Int J Mol Sci (2017) 0.75
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology (1992) 9.30
Alzheimer's disease: clinical trials and drug development. Lancet Neurol (2010) 4.65
The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis. J Neuropathol Exp Neurol (1996) 4.39
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron (1999) 3.49
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med (2012) 3.31
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci U S A (2004) 2.48
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Mol Psychiatry (2004) 1.79
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol (2003) 1.66
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci (2010) 1.60
Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J Neurochem (1999) 1.60
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci (2012) 1.60
A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice. J Pharmacol Exp Ther (2001) 1.43
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther (2008) 1.41
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci (2012) 1.31
Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. J Pharmacol Exp Ther (2007) 1.30
NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. Neurobiol Dis (2009) 1.26
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci (2007) 1.24
The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes. Neuroscience (1997) 1.21
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacol Res (2010) 1.20
Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert Opin Pharmacother (2005) 1.18
NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Rev (2005) 1.16
A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication. J Biol Chem (2004) 1.12
Peptide neuroprotection through specific interaction with brain tubulin. J Neurochem (2006) 1.08
The peptide NAP promotes neuronal growth and differentiation through extracellular signal-regulated protein kinase and Akt pathways, and protects neurons co-cultured with astrocytes damaged by ethanol. J Neurochem (2007) 1.05
Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. Hum Mol Genet (2010) 1.03
NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death. Stroke (2002) 1.01
Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta Neuropathol (2010) 1.00
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiol Dis (2005) 0.99
Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures. J Mol Neurosci (2005) 0.95
Increased throughput assays of locomotor dysfunction in Drosophila larvae. J Neurosci Methods (2011) 0.94
Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons. Neurobiol Dis (2009) 0.93
Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis (2011) 0.93
NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell. Curr Alzheimer Res (2007) 0.91
The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities. PLoS One (2012) 0.90
Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy. Neuropsychiatr Dis Treat (2012) 0.90
Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. Curr Top Med Chem (2011) 0.89
Tau pathology and future therapeutics. Curr Alzheimer Res (2010) 0.88
Tau neurofibrillary pathology and microtubule stability. J Mol Neurosci (2002) 0.88
NAP enhances neurodevelopment of newborn apolipoprotein E-deficient mice subjected to hypoxia. J Pharmacol Exp Ther (2006) 0.85
Novel therapeutics for Alzheimer's disease: an update. Curr Opin Drug Discov Devel (2010) 0.84
The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush. Graefes Arch Clin Exp Ophthalmol (2008) 0.84
NAP mechanisms of neuroprotection. J Mol Neurosci (2004) 0.83
Amyloid peptide toxicity and microtubule-stabilizing drugs. J Mol Neurosci (2002) 0.81
Prevention and management of hypotension during spinal anaesthesia for elective Caesarean section: a survey of practice. Anaesthesia (2001) 1.44
Cancer risk in women exposed to diethylstilbestrol in utero. JAMA (1998) 1.32
TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow? Anim Genet (2003) 0.99
Gamma-glutamyl-transpeptidase in myocardial infarction. Clinical and experimental studies. Circulation (1969) 0.97
Increased throughput assays of locomotor dysfunction in Drosophila larvae. J Neurosci Methods (2011) 0.94
Potamotrygon spp.: elasmobranchs with low urea content. Science (1967) 0.87
A prospective, randomised, single-blind pilot study to determine the effect of anaesthetic technique on troponin T release after off-pump coronary artery surgery. Anaesthesia (2004) 0.86
The effect of glucagon on the coronary circulation in man. Circulation (1969) 0.81
Relationship of bovine leukocyte adhesion deficiency with genetic merit for performance traits. J Dairy Sci (1996) 0.78
Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Biochem Soc Trans (2006) 0.78
The negative potential wave evoked in cuneate nucleus by stimulation of afferent pathways: its origins and susceptibility to inhibition. J Physiol (1976) 0.78
Spinal anaesthesia for caesarean section: current clinical practice. Hosp Med (2000) 0.76
Epilepsy and membrane Na+K+ATPase: changes in activity using an experimental model of epilepsy. Acta Physiol Lat Am (1980) 0.76
Epidural fixation. Anaesthesia (2002) 0.75
A close shave. Anaesthesia (1999) 0.75
Validation and application of an assay for deoxyribonucleic acid to estimate concentrations of bull sperm. J Dairy Sci (1990) 0.75
Membrane Na+K+ATPase activity: changes using an experimental model of alcohol dependence and withdrawal. Pharmacol Biochem Behav (1980) 0.75
Relationship between individual herd-heritability estimates and sire misidentification rate. J Dairy Sci (2008) 0.75
Sedation and analgesia for transvaginal oocyte retrieval: an audit resulting in a change of clinical practice. Hum Fertil (Camb) (2001) 0.75
Helping a child develop. Nurs Times (1975) 0.75
Relationship of the estrous cycle to milk composition. J Dairy Sci (1979) 0.75
An analytical model for the estimation of chromosome substitution effects in the offspring of individuals heterozygous at a segregating marker locus. Theor Appl Genet (1990) 0.75