Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMID 23612425)

Published in Pharmacol Ther on April 20, 2013

Authors

Halina Dobrzynski1, Robert H Anderson, Andrew Atkinson, Zoltan Borbas, Alicia D'Souza, John F Fraser, Shin Inada, Sunil J R J Logantha, Oliver Monfredi, Gwilym M Morris, Anton F M Moorman, Thodora Nikolaidou, Heiko Schneider, Viktoria Szuts, Ian P Temple, Joseph Yanni, Mark R Boyett

Author Affiliations

1: University of Manchester, UK. halina.dobrzynski@manchester.ac.uk

Articles citing this

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nat Commun (2014) 1.53

Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction. Front Physiol (2015) 0.93

Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells. PLoS One (2014) 0.88

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways. Prog Biophys Mol Biol (2015) 0.87

Functional role of voltage gated Ca(2+) channels in heart automaticity. Front Physiol (2015) 0.86

Molecular Pathophysiology of Congenital Long QT Syndrome. Physiol Rev (2017) 0.85

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circ Arrhythm Electrophysiol (2015) 0.84

Ion Channels in the Heart. Compr Physiol (2015) 0.83

Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2. Proc Natl Acad Sci U S A (2015) 0.80

Three-dimensional cardiac computational modelling: methods, features and applications. Biomed Eng Online (2015) 0.80

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? Br J Pharmacol (2016) 0.78

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current. J Interv Card Electrophysiol (2016) 0.78

Cell junctions in the specialized conduction system of the heart. Cell Commun Adhes (2014) 0.77

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction. J Interv Card Electrophysiol (2015) 0.77

Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance. Front Physiol (2016) 0.76

Sudden death due to the atrioventricular node contusion: Three cases report. Medicine (Baltimore) (2017) 0.75

Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications. Clin Med Insights Cardiol (2016) 0.75

Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy. PLoS One (2016) 0.75

Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: Role of fibrosis and connexin remodelling. J Mol Cell Cardiol (2016) 0.75

Ventricular arrhythmias and the His-Purkinje system. Nat Rev Cardiol (2016) 0.75

[Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation]. Herzschrittmacherther Elektrophysiol (2017) 0.75

Morpho-functional characterization of the systemic venous pole of the reptile heart. Sci Rep (2017) 0.75

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling. Sci Rep (2017) 0.75

Development of the cardiac pacemaker. Cell Mol Life Sci (2016) 0.75

Articles by these authors

Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol (2005) 5.63

Procalcitonin algorithm in critically ill adults with undifferentiated infection or suspected sepsis. A randomized controlled trial. Am J Respir Crit Care Med (2014) 3.10

Viewpoint: is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone? J Appl Physiol (1985) (2013) 2.92

New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation (2007) 2.89

Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol (2007) 2.83

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation (2009) 2.58

Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res (2006) 2.17

Nomenclature for congenital and paediatric cardiac disease: historical perspectives and The International Pediatric and Congenital Cardiac Code. Cardiol Young (2008) 2.10

Lineage and morphogenetic analysis of the cardiac valves. Circ Res (2004) 2.06

Is complete heart block after surgical closure of ventricular septum defects still an issue? Ann Thorac Surg (2006) 2.05

Appraisal of the endotracheal tube as an alternative to the intercostal catheter. Emerg Med Australas (2010) 1.98

The morphological spectrum of ventricular noncompaction. Cardiol Young (2005) 1.96

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart. Circ Res (2003) 1.90

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A (2003) 1.86

Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circ Res (2007) 1.85

The nomenclature, definition and classification of cardiac structures in the setting of heterotaxy. Cardiol Young (2007) 1.83

Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node. Circulation (2007) 1.80

Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel. J Biol Chem (2003) 1.79

Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI ≥30: a randomised controlled trial. Intensive Care Med (2015) 1.79

Standalone balloon aortic valvuloplasty: indications and outcomes from the UK in the transcatheter valve era. Catheter Cardiovasc Interv (2013) 1.72

A simplified categorization for common arterial trunk. J Thorac Cardiovasc Surg (2010) 1.70

In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart. Cardiovasc Res (2005) 1.68

Impact of blood product transfusion on short and long-term survival after cardiac surgery: more evidence. Ann Thorac Surg (2012) 1.66

Ageing-dependent remodelling of ion channel and Ca2+ clock genes underlying sino-atrial node pacemaking. Exp Physiol (2011) 1.66

Development of the cardiac conduction system as delineated by minK-lacZ. J Cardiovasc Electrophysiol (2003) 1.65

Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ Res (2006) 1.63

The seasonality in heart failure deaths and total cardiovascular deaths. Aust N Z J Public Health (2008) 1.62

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet (2004) 1.61

Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res (2006) 1.61

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking. J Physiol (2004) 1.59

Ventricular myocardial architecture as visualised in postmortem swine hearts using magnetic resonance diffusion tensor imaging. Eur J Cardiothorac Surg (2005) 1.56

Impact of multiplanar review of three-dimensional echocardiographic data on management of congenital heart disease. Ann Thorac Surg (2008) 1.55

The extent of the specialized atrioventricular ring tissues. Heart Rhythm (2009) 1.53

Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart (2003) 1.53

Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis. J Nucl Cardiol (2012) 1.51

Visceral heterotaxy, isomerism, and splenic structure. Cardiol Young (2005) 1.51

Left ventricle structural remodelling in the prediabetic Goto-Kakizaki rat. Exp Physiol (2011) 1.51

Spatiotemporal analysis of programmed cell death during mouse cardiac septation. Anat Rec A Discov Mol Cell Evol Biol (2004) 1.51

Development of the pulmonary vein. Int J Cardiol (2011) 1.43

Effect of preoperative renal function on long-term survival after cardiac surgery. J Thorac Cardiovasc Surg (2012) 1.43

Sustained inward current and pacemaker activity of mammalian sinoatrial node. J Cardiovasc Electrophysiol (2002) 1.43

Splenic rupture as a presenting feature of endocarditis. Eur J Cardiothorac Surg (2009) 1.42

Atrial structure and fibres: morphologic bases of atrial conduction. Cardiovasc Res (2002) 1.41

Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. J Crit Care (2012) 1.41

3D virtual human atria: A computational platform for studying clinical atrial fibrillation. Prog Biophys Mol Biol (2011) 1.41

The association between preoperative eGFR and outcomes in cardiac surgical patients. Crit Care Resusc (2009) 1.40

Structural-functional correlates of the 3-dimensional arrangement of the myocytes making up the ventricular walls. J Thorac Cardiovasc Surg (2008) 1.40

Visualising the conduction tissues. Heart (2013) 1.39

Intrahepatic right-to-left shunting after the Fontan operation. Cardiol Young (2002) 1.39

Effect of adrenergic stimulation on action potential duration restitution in humans. Circulation (2003) 1.39

Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells. J Cardiovasc Electrophysiol (2002) 1.38

Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts. J Mol Cell Cardiol (2010) 1.37

Anatomy of the aortic valvar complex and its implications for transcatheter implantation of the aortic valve. Circ Cardiovasc Interv (2008) 1.35

Anatomy of the mitral valvular complex and its implications for transcatheter interventions for mitral regurgitation. J Am Coll Cardiol (2010) 1.35

Tetralogy of Fallot. Orphanet J Rare Dis (2009) 1.33

External aortic root support: NICE guidance. Heart (2011) 1.31

Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53. Structure (2012) 1.30

Collagen in the scarless fetal skin wound: detection with picrosirius-polarization. Wound Repair Regen (2005) 1.29

Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development. IEEE Trans Med Imaging (2012) 1.29

Septation and separation within the outflow tract of the developing heart. J Anat (2003) 1.28

Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts. PLoS One (2012) 1.28

Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Crit Care Resusc (2012) 1.27

Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: a comprehensive review. Crit Care (2014) 1.26

Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy. Biophys J (2009) 1.25

Management of acute smoke inhalation injury. Crit Care Resusc (2010) 1.25

Pacing-induced spontaneous activity in myocardial sleeves of pulmonary veins after treatment with ryanodine. Circulation (2003) 1.24

Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart. Circ Res (2010) 1.24

Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45. Cardiovasc Res (2006) 1.23

Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Crit Care (2012) 1.23

Isolated left ventricular non-compaction: the case for abnormal myocardial development. Cardiol Young (2007) 1.22

Echocardiographic characteristics of the criss-cross heart. Int J Cardiol (2009) 1.21

Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve. JACC Cardiovasc Interv (2008) 1.21

Development of the atrial septum. Heart (2016) 1.20

Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis. Crit Care Med (2006) 1.20

Pulmonary atresia with intact ventricular septum: range of morphology in a population-based study. J Am Coll Cardiol (2002) 1.19

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res (2010) 1.18

Controversies, genetics, diagnostic assessment, and outcomes relating to the heterotaxy syndrome. Cardiol Young (2007) 1.18

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria. J Physiol (2013) 1.18

Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node. J Histochem Cytochem (2002) 1.16

Surgical substrates of postoperative junctional ectopic tachycardia in congenital heart defects. J Thorac Cardiovasc Surg (2002) 1.16

Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias. Circ Res (2004) 1.15

The epidemiology of silent brain infarction: a systematic review of population-based cohorts. BMC Med (2014) 1.14

Two distinct pools of mesenchyme contribute to the development of the atrial septum. Circ Res (2006) 1.13

The development and structure of the ventricles in the human heart. Pediatr Cardiol (2009) 1.13

The anatomy and physiology of the sinoatrial node--a contemporary review. Pacing Clin Electrophysiol (2010) 1.12

Children with burn injuries--assessment of trauma, neglect, violence and abuse. J Inj Violence Res (2011) 1.11

Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node. Prog Biophys Mol Biol (2007) 1.11