Published in PLoS One on April 16, 2013
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev (2014) 0.98
The role of mRNA splicing in prostate cancer. Asian J Androl (2014) 0.82
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2. Cell Rep (2016) 0.76
Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness. Sci Rep (2015) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet (2007) 7.42
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science (1995) 6.85
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
Chromatin organization marks exon-intron structure. Nat Struct Mol Biol (2009) 5.90
PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem (2001) 5.85
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Epigenetics in alternative pre-mRNA splicing. Cell (2011) 4.74
Regulatory roles of natural antisense transcripts. Nat Rev Mol Cell Biol (2009) 4.48
The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study. BMJ (2012) 3.82
Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47
Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A (2004) 3.39
Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet (2007) 3.18
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. Lancet Oncol (2004) 2.08
Cancer as a metabolic disease. Nutr Metab (Lond) (2010) 1.98
A methyl transferase links the circadian clock to the regulation of alternative splicing. Nature (2010) 1.88
Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS One (2011) 1.75
Pre-mRNA splicing is a determinant of histone H3K36 methylation. Proc Natl Acad Sci U S A (2011) 1.66
Pause locally, splice globally. Trends Cell Biol (2011) 1.55
PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci (2000) 1.52
REST in good times and bad: roles in tumor suppressor and oncogenic activities. Cell Cycle (2006) 1.51
New connections between splicing and human disease. Trends Genet (2012) 1.39
Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci (2010) 1.37
Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol Cancer Ther (2005) 1.37
Substances that can change alternative splice-site selection. Biochem Soc Trans (2008) 1.34
The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiol Dis (2010) 1.32
A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res (2000) 1.31
Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res (2009) 1.30
Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST. Mol Cell Biol (1999) 1.28
Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res Mol Brain Res (1999) 1.20
Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers. DNA Cell Biol (2011) 1.18
The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17
Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation. Mol Psychiatry (2004) 1.08
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet (2007) 1.08
Chromatin and alternative splicing. Cold Spring Harb Symp Quant Biol (2011) 1.05
The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers. RNA Biol (2011) 1.04
NOA1 is an essential GTPase required for mitochondrial protein synthesis. Mol Biol Cell (2010) 1.00
Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons. J Neurosci (1994) 0.98
Decreased EBNA-1-specific CD8+ T cells in patients with Epstein-Barr virus-associated nasopharyngeal carcinoma. Proc Natl Acad Sci U S A (2009) 0.98
How much REST is enough? Cancer Cell (2008) 0.98
PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia. Differentiation (2011) 0.97
Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization. J Biol Chem (2001) 0.94
PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease. Neurobiol Dis (2011) 0.91
mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells. Biochim Biophys Acta (2008) 0.90
Dual role of NRSF/REST in activation and repression of the glucocorticoid response. J Biol Chem (2007) 0.90
The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists. PPAR Res (2012) 0.88
Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice. Neuroscience (2011) 0.87
Characterization of the nuclear targeting signal of REST/NRSF. Neurosci Lett (2006) 0.87
Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. J Biol Chem (2011) 0.86
REST is a novel prognostic factor and therapeutic target for medulloblastoma. Mol Cancer Ther (2012) 0.85
Cell-type non-selective transcription of mouse and human genes encoding neural-restrictive silencer factor. Brain Res Mol Brain Res (2001) 0.84
Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease. Pharmacol Biochem Behav (2010) 0.83
The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination. PPAR Res (2012) 0.83
Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma. J Mol Neurosci (2000) 0.82
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha. Proc Natl Acad Sci U S A (2006) 2.16
Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther (2006) 2.04
The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry (2005) 1.87
Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Hum Mol Genet (2008) 1.73
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther (2007) 1.57
MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl) (2005) 1.35
Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther (2007) 1.31
Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochem Pharmacol (2009) 1.27
Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem (2007) 1.21
Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther (2008) 1.19
Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaques. Virology (2006) 1.18
Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes. J Pharmacol Exp Ther (2008) 1.16
A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain. J Pharmacol Exp Ther (2009) 1.15
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet (2007) 1.08
Trace amine associated receptor 1 signaling in activated lymphocytes. J Neuroimmune Pharmacol (2011) 1.05
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res (2010) 1.03
Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol Biochem Behav (2011) 1.01
Receptor regulation of gene expression of axon guidance molecules: implications for adaptation. Mol Pharmacol (2006) 1.01
A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug Alcohol Depend (2010) 0.98
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res (2002) 0.97
Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. Am J Med Genet B Neuropsychiatr Genet (2012) 0.94
Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evol Biol (2010) 0.94
Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains. J Biol Chem (2013) 0.93
Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque. Behav Genet (2008) 0.91
Nonhuman primate models in the genomic era: a paradigm shift. ILAR J (2013) 0.89
Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association. J Neurosci Res (2008) 0.89
The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis. Horm Behav (2009) 0.88
Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques. Am J Med Genet B Neuropsychiatr Genet (2009) 0.87
MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. J Psychopharmacol (2008) 0.87
Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse (2002) 0.85
High-turnover supramolecular catalysis by a protected ruthenium(II) complex in aqueous solution. J Am Chem Soc (2011) 0.85
Trace amine associated receptor 1 modulates behavioral effects of ethanol. Subst Abuse (2013) 0.84
Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics (2013) 0.84
5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro. Gene (2009) 0.84
Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. Eur J Pharmacol (2003) 0.84
Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus. Brain Res (2011) 0.82
Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling. Genome Biol (2006) 0.81
Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation. Brain Res (2005) 0.81
Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders. Biochem Pharmacol (2013) 0.81
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorg Med Chem (2011) 0.80
Variants of the primate vesicular monoamine transporter-2. Brain Res Mol Brain Res (2005) 0.80
Resource brief: the National Non-Human Primate DNA Bank. Methods (2009) 0.79
Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. J Neurosci Methods (2005) 0.78
Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus. Neuroreport (2006) 0.77
Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. J Neurovirol (2011) 0.77
Genetic tools for understanding the primate genome. Editorial. Methods (2009) 0.75
FUNCTIONAL ASSESSMENT OF INTRAHYPOTHALAMIC IMPLANTS OF IMMORTALIZED GONADOTROPIN-RELEASING HORMONE-SECRETING CELLS IN FEMALE HYPOGONADAL MICE. Cell Transplant (1993) 0.75