Lipopolysaccharide modifications of a cholera vaccine candidate based on outer membrane vesicles reduce endotoxicity and reveal the major protective antigen.

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Published in Infect Immun on April 29, 2013

Authors

Deborah R Leitner1, Sandra Feichter, Kristina Schild-Prüfert, Gerald N Rechberger, Joachim Reidl, Stefan Schild

Author Affiliations

1: Institute of Molecular Biosciences, University of Graz, Graz, Austria.

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A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99

Studies on transformation of Escherichia coli with plasmids. J Mol Biol (1983) 116.81

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol (1995) 46.37

Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70

A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. Anal Biochem (1982) 36.39

A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol (1988) 31.85

Lipopolysaccharide endotoxins. Annu Rev Biochem (2001) 18.88

WHO estimates of the causes of death in children. Lancet (2005) 18.33

Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect Immun (1991) 15.39

Cholera. Clin Microbiol Rev (1995) 12.33

Cholera. Lancet (2004) 10.22

Adhesive properties of Vibrio cholerae: nature of the interaction with intact mucosal surfaces. Infect Immun (1976) 5.36

Cholera vaccines: WHO position paper. Wkly Epidemiol Rec (2010) 5.24

Field trial of a locally produced, killed, oral cholera vaccine in Vietnam. Lancet (1997) 4.56

Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor. Microbiol Immunol (1986) 4.38

Role of chemotaxis in the association of motile bacteria with intestinal mucosa: in vivo studies. Infect Immun (1981) 4.34

Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol (2010) 4.13

Cholera. Lancet (2012) 3.80

The true burden and risk of cholera: implications for prevention and control. Lancet Infect Dis (2007) 3.61

Selection for in vivo regulators of bacterial virulence. Proc Natl Acad Sci U S A (2001) 2.98

A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest (1996) 2.94

Synergistic protective effect in rabbits of immunization with Vibrio cholerae lipopolysaccharide and toxin/toxoid. Infect Immun (1976) 2.92

Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter. J Bacteriol (1989) 2.87

Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype. J Infect Dis (1994) 2.67

New medium for the production of cholera toxin by Vibrio cholerae O1 biotype El Tor. J Clin Microbiol (1985) 2.43

Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae O139 vaccine prototype. Lancet (1995) 2.43

AN ELECTRON MICROSCOPE STUDY OF VIBRIO FLAGELLA. J Gen Microbiol (1963) 2.40

MeNZB: a safe and highly immunogenic tailor-made vaccine against the New Zealand Neisseria meningitidis serogroup B disease epidemic strain. Vaccine (2005) 2.20

Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity. Infect Immun (2001) 2.16

Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease. NIPH Ann (1991) 2.13

Initial clinical studies of CVD 112 Vibrio cholerae O139 live oral vaccine: safety and efficacy against experimental challenge. J Infect Dis (1995) 2.10

Live attenuated oral cholera vaccines. Expert Rev Vaccines (2006) 2.07

The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escherichia coli O antigen assembly is independent of the chemical structure of the O repeat. J Biol Chem (1999) 2.06

Thymus-independent and thymus-dependent responses to polysaccharide antigens. J Infect Dis (1992) 1.98

Antibodies directed against the toxin-coregulated pilus isolated from Vibrio cholerae provide protection in the infant mouse experimental cholera model. J Infect Dis (1990) 1.97

Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis. Vaccine (2009) 1.88

Lipopolysaccharides of Vibrio cholerae. I. Physical and chemical characterization. Biochim Biophys Acta (2003) 1.86

Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in gram-positive and gram-negative bacteria. Proc Natl Acad Sci U S A (2012) 1.83

Cholera outbreak --- Haiti, October 2010. MMWR Morb Mortal Wkly Rep (2010) 1.77

Molecular basis of reduced potency of underacylated endotoxins. J Immunol (2005) 1.77

Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing. Proc Natl Acad Sci U S A (2008) 1.63

Experimental studies on cholera immunization. 4. The antibody response to formalinized Vibrio cholerae and purified endotoxin with special reference to protective capacity. Int Arch Allergy Appl Immunol (1975) 1.56

Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice. Infect Immun (2008) 1.50

Significance of toxin-coregulated pili as protective antigens of Vibrio cholerae in the infant mouse model. Vaccine (1989) 1.50

Safety and immunogenicity of an oral recombinant cholera B subunit-whole cell vaccine in Swedish volunteers. Vaccine (1992) 1.49

Quantification of bacterial lipopolysaccharides by the purpald assay: measuring formaldehyde generated from 2-keto-3-deoxyoctonate and heptose at the inner core by periodate oxidation. Anal Biochem (1999) 1.46

Infectious diseases. Haiti's outbreak is latest in cholera's new global assault. Science (2010) 1.45

Synthesis, characterization, and some immunological properties of conjugates composed of the detoxified lipopolysaccharide of Vibrio cholerae O1 serotype Inaba bound to cholera toxin. Infect Immun (1992) 1.45

Enteric infections and the vaccines to counter them: future directions. Vaccine (2006) 1.45

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression. Vaccine (2011) 1.39

A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2. J Infect Dis (2000) 1.38

Wzx proteins involved in biosynthesis of O antigen function in association with the first sugar of the O-specific lipopolysaccharide subunit. Microbiology (2004) 1.36

Gram-negative outer membrane vesicles: beyond the cell surface. Geobiology (2008) 1.35

Lack of cross-protection against diarrhea due to Vibrio cholerae O139 (Bengal strain) after oral immunization of rabbits with V. cholerae O1 vaccine strain CVD103-HgR. J Infect Dis (1994) 1.35

Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera. Infect Immun (2008) 1.32

Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants. Vaccine (2006) 1.31

The toxin-coregulated pilus (TCP) of Vibrio cholerae: molecular cloning of genes involved in pilus biosynthesis and evaluation of TCP as a protective antigen in the infant mouse model. Microb Pathog (1989) 1.29

Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and Shigella sonnei proteosome-lipopolysaccharide vaccines in animal models. Infect Immun (1993) 1.29

The major subunit of the toxin-coregulated pilus TcpA induces mucosal and systemic immunoglobulin A immune responses in patients with cholera caused by Vibrio cholerae O1 and O139. Infect Immun (2004) 1.25

Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster. Infect Immun (2002) 1.25

Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation. Mol Microbiol (2011) 1.25

Serogroup B meningococcal vaccines-an unfinished story. Lancet Infect Dis (2010) 1.20

Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh. J Infect Dis (2005) 1.19

Evaluation of different immunization schedules for oral cholera B subunit-whole cell vaccine in Swedish volunteers. Vaccine (1993) 1.19

Characterization of native outer membrane vesicles from lpxL mutant strains of Neisseria meningitidis for use in parenteral vaccination. Infect Immun (2005) 1.17

Synthesis, characterization, and immunological properties in mice of conjugates composed of detoxified lipopolysaccharide of Salmonella paratyphi A bound to tetanus toxoid with emphasis on the role of O acetyls. Infect Immun (1996) 1.17

Lack of cross-protection against diarrhea due to Vibrio cholerae O1 after oral immunization of rabbits with V. cholerae O139 Bengal. J Infect Dis (1994) 1.15

Role of Vibrio cholerae O139 surface polysaccharides in intestinal colonization. Infect Immun (2002) 1.13

Investigations into the safety and immunogenicity of a killed oral cholera vaccine developed in Viet Nam. Bull World Health Organ (2002) 1.12

The vaccine candidate Vibrio cholerae 638 is protective against cholera in healthy volunteers. Infect Immun (2005) 1.12

Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility. Infect Immun (2010) 1.12

Immunological memory after immunization with oral cholera B subunit--whole-cell vaccine in Swedish volunteers. Vaccine (1994) 1.12

Oral vaccines against cholera. Clin Infect Dis (2011) 1.11

An Address on Cholera and its Bacillus. Br Med J (1884) 1.11

Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol (2012) 1.11

Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition. Mol Microbiol (2011) 1.10

The toxin-coregulated pilus is a colonization factor and protective antigen of Vibrio cholerae El Tor. Microb Pathog (1996) 1.10

Polymyxin B resistance in El Tor Vibrio cholerae requires lipid acylation catalyzed by MsbB. J Bacteriol (2010) 1.09

Molecular and functional characterization of O antigen transfer in Vibrio cholerae. J Biol Chem (2005) 1.08

Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Clin Vaccine Immunol (2012) 1.07

Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activation. Infect Immun (2008) 1.07

Field trial of oral cholera vaccines in Bangladesh: evaluation of anti-bacterial and anti-toxic breast-milk immunity in response to ingestion of the vaccines. Vaccine (1990) 1.06

An old enemy returns. Bull World Health Organ (2009) 1.04

Protective immunity induced in mice by detoxified salmonella lipopolysaccharide. J Med Microbiol (1990) 1.03

Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo. J Leukoc Biol (1996) 1.01

Vibrio cholerae: lessons for mucosal vaccine design. Expert Rev Vaccines (2011) 1.00

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Intranasal immunization with nontypeable Haemophilus influenzae outer membrane vesicles induces cross-protective immunity in mice. PLoS One (2012) 0.97

Next-generation outer membrane vesicle vaccines against Neisseria meningitidis based on nontoxic LPS mutants. Hum Vaccin (2011) 0.95

Lipidation of an FlrC-dependent protein is required for enhanced intestinal colonization by Vibrio cholerae. J Bacteriol (2007) 0.91

Immunization of mice with vibrio cholerae outer-membrane vesicles protects against hyperinfectious challenge and blocks transmission. J Infect Dis (2011) 0.90

Vibrio cholerae O139 conjugate vaccines: synthesis and immunogenicity of V. cholerae O139 capsular polysaccharide conjugates with recombinant diphtheria toxin mutant in mice. Infect Immun (2000) 0.90

Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP-1 alpha and MIP-1 beta secretion without inducing TNF-alpha and IL-1 beta. J Hum Virol (1999) 0.90

Delivery systems: a vaccine strategy for overcoming mucosal tolerance? Expert Rev Vaccines (2009) 0.90

Virulence, inflammatory potential, and adaptive immunity induced by Shigella flexneri msbB mutants. Infect Immun (2009) 0.88

A noncovalent complex vaccine prepared with detoxified Escherichia coli J5 (Rc chemotype) lipopolysaccharide and Neisseria meningitidis Group B outer membrane protein produces protective antibodies against gram-negative bacteremia. J Infect Dis (1996) 0.86

A Vibrio cholerae classical TcpA amino acid sequence induces protective antibody that binds an area hypothesized to be important for toxin-coregulated pilus structure. Infect Immun (2004) 0.85

Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects. Vaccine (2003) 0.85

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