|
1
|
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
|
J Med Chem
|
2013
|
3.27
|
|
2
|
Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila.
|
Curr Biol
|
2006
|
2.01
|
|
3
|
A comparison of cDNA, oligonucleotide, and Affymetrix GeneChip gene expression microarray platforms.
|
J Biomol Tech
|
2004
|
1.73
|
|
4
|
Cyclodextrin protects podocytes in diabetic kidney disease.
|
Diabetes
|
2013
|
1.71
|
|
5
|
Labile iron in parenteral iron formulations: a quantitative and comparative study.
|
Nephrol Dial Transplant
|
2004
|
1.68
|
|
6
|
Electronic health record design and implementation for pharmacogenomics: a local perspective.
|
Genet Med
|
2013
|
1.48
|
|
7
|
The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine.
|
Dev Biol
|
2004
|
1.42
|
|
8
|
ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.
|
Cancer Res
|
2007
|
1.23
|
|
9
|
Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation.
|
J ECT
|
2006
|
1.22
|
|
10
|
Extracting drug-drug interaction articles from MEDLINE to improve the content of drug databases.
|
AMIA Annu Symp Proc
|
2005
|
1.16
|
|
11
|
In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models.
|
Prostate
|
2006
|
1.14
|
|
12
|
Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans.
|
Dev Biol
|
2004
|
1.04
|
|
13
|
Quill: a novel approach to structured reporting.
|
AMIA Annu Symp Proc
|
2003
|
1.04
|
|
14
|
Unraveling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration.
|
Genetics
|
2007
|
1.04
|
|
15
|
The impact of nitrogen contamination and river modification on a Mississippi River floodplain lake.
|
Sci Total Environ
|
2013
|
1.04
|
|
16
|
The influence of patient size on dose conversion coefficients: a hybrid phantom study for adult cardiac catheterization.
|
Phys Med Biol
|
2009
|
1.03
|
|
17
|
Engraftment of retroviral EGFP-transduced bone marrow in mice prevents rejection of EGFP-transgenic skin grafts.
|
Mol Ther
|
2003
|
1.03
|
|
18
|
Cerebral cortex plasticity after 90 days of bed rest: data from TMS and fMRI.
|
Aviat Space Environ Med
|
2010
|
1.00
|
|
19
|
A genetic hierarchy controlling cell polarity.
|
Nat Cell Biol
|
2003
|
0.99
|
|
20
|
Mining manufacturing data for discovery of high productivity process characteristics.
|
J Biotechnol
|
2010
|
0.96
|
|
21
|
High resolution three-dimensional cine phase contrast MRI of small intracranial aneurysms using a stack of stars k-space trajectory.
|
J Magn Reson Imaging
|
2011
|
0.94
|
|
22
|
A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia.
|
Schizophr Res
|
2007
|
0.94
|
|
23
|
The stem cell continuum: cell cycle, injury, and phenotype lability.
|
Ann N Y Acad Sci
|
2007
|
0.92
|
|
24
|
Lower limb immobilization is associated with increased corticospinal excitability.
|
Exp Brain Res
|
2007
|
0.89
|
|
25
|
Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration.
|
Eur J Cell Biol
|
2008
|
0.89
|
|
26
|
Variation in use of informatics tools among providers in a diabetes clinic.
|
AMIA Annu Symp Proc
|
2007
|
0.88
|
|
27
|
Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.
|
Diabetes
|
2009
|
0.87
|
|
28
|
Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.
|
Diabetes
|
2013
|
0.87
|
|
29
|
Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study.
|
Front Psychiatry
|
2010
|
0.86
|
|
30
|
Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.
|
J Med Chem
|
2014
|
0.86
|
|
31
|
A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia.
|
Schizophr Res
|
2007
|
0.85
|
|
32
|
Expression of cell cycle-related genes with cytokine-induced cell cycle progression of primitive hematopoietic stem cells.
|
Stem Cells Dev
|
2010
|
0.85
|
|
33
|
Multivariate analysis of cell culture bioprocess data--lactate consumption as process indicator.
|
J Biotechnol
|
2012
|
0.83
|
|
34
|
Skin dose mapping for fluoroscopically guided interventions.
|
Med Phys
|
2011
|
0.83
|
|
35
|
Measurement of tibiofemoral kinematics using highly accelerated 3D radial sampling.
|
Magn Reson Med
|
2012
|
0.82
|
|
36
|
Applying human factors research to alert-fatigue in e-prescribing.
|
AMIA Annu Symp Proc
|
2007
|
0.82
|
|
37
|
Natural language processing: algorithms and tools to extract computable information from EHRs and from the biomedical literature.
|
J Am Med Inform Assoc
|
2013
|
0.82
|
|
38
|
Inhibitory potential of tea polyphenolics and influence of extraction time against Helicobacter pylori and lack of inhibition of beneficial lactic acid bacteria.
|
J Med Food
|
2011
|
0.82
|
|
39
|
Comparison of blood velocity measurements between ultrasound Doppler and accelerated phase-contrast MR angiography in small arteries with disturbed flow.
|
Phys Med Biol
|
2011
|
0.82
|
|
40
|
A pilot functional MRI study of the effects of prefrontal rTMS on pain perception.
|
Pain Med
|
2013
|
0.82
|
|
41
|
Computerized provider-order entry: challenges, achievements, and opportunities.
|
J Am Med Inform Assoc
|
2011
|
0.81
|
|
42
|
The impact of anthropometric patient-phantom matching on organ dose: a hybrid phantom study for fluoroscopy guided interventions.
|
Med Phys
|
2011
|
0.81
|
|
43
|
Quantitative magnetic resonance imaging of pulmonary hypertension: a practical approach to the current state of the art.
|
J Thorac Imaging
|
2014
|
0.80
|
|
44
|
Flow characteristics in a canine aneurysm model: a comparison of 4D accelerated phase-contrast MR measurements and computational fluid dynamics simulations.
|
Med Phys
|
2011
|
0.79
|
|
45
|
A pilot feasibility study of daily rTMS to modify corticospinal excitability during lower limb immobilization.
|
Ther Clin Risk Manag
|
2008
|
0.78
|
|
46
|
Images in cardiovascular medicine. Myocardial rupture, microvascular obstruction, and infarct expansion: elucidation by cardiac magnetic resonance.
|
Circulation
|
2003
|
0.78
|
|
47
|
Volumetric late gadolinium-enhanced myocardial imaging with retrospective inversion time selection.
|
J Magn Reson Imaging
|
2013
|
0.77
|
|
48
|
Time resolved contrast enhanced intracranial MRA using a single dose delivered as sequential injections and highly constrained projection reconstruction (HYPR CE).
|
Magn Reson Med
|
2011
|
0.76
|
|
49
|
HYPR TOF: time-resolved contrast-enhanced intracranial MR angiography using time-of-flight as the spatial constraint.
|
J Magn Reson Imaging
|
2011
|
0.75
|
|
50
|
Complex repair of pectus excavatum recurrence and massive chest wall defect and lung herniation after prior open repair.
|
Ann Thorac Surg
|
2013
|
0.75
|
|
51
|
An IT CEO talks about the BYOD trend.
|
Biomed Instrum Technol
|
2014
|
0.75
|
|
52
|
Hemodynamic assessment in a child with renovascular hypertension using time-resolved three-dimensional cine phase-contrast MRI.
|
J Magn Reson Imaging
|
2014
|
0.75
|
|
53
|
1500: STEROID USE FOR REFRACTORY HYPOTENSION IN CONGENITAL DIAPHRAGMATIC HERNIA INCREASES SEPSIS RISK.
|
Crit Care Med
|
2016
|
0.75
|
|
54
|
Development and Characterization of 12 Novel Polymorphic Microsatellite Loci for the Mammal Chewing Louse Geomydoecus aurei (Insecta: Phthiraptera) and a Comparison of Next-Generation Sequencing Approaches for Use in Parasitology.
|
J Parasitol
|
2017
|
0.75
|
|
55
|
Using continuous quality improvement to implement evidence-based medicine.
|
Lippincotts Case Manag
|
2006
|
0.75
|
|
56
|
Anti-hyperglycemia properties of Tea (Camellia sinensis) bioactives using in vitro assay models and influence of extraction time.
|
J Med Food
|
2011
|
0.75
|