Published in Pharmacol Biochem Behav on May 08, 2013
Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine. Mol Pharmacol (2013) 0.99
Recent insights into the mode of action of memantine and ketamine. Curr Opin Pharmacol (2014) 0.94
Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine. Mol Psychiatry (2015) 0.86
Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. Br J Pharmacol (2015) 0.82
NMDA receptor antagonist ketamine impairs feature integration in visual perception. PLoS One (2013) 0.80
Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism? PLoS One (2014) 0.77
Memantine and ketamine differentially alter NMDA receptor desensitization. J Neurosci (2017) 0.75
The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology (1999) 3.78
Ketamine--its pharmacology and therapeutic uses. Anesthesiology (1982) 3.61
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov (2006) 3.58
Synaptic dysfunction in depression: potential therapeutic targets. Science (2012) 3.15
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. Neuropharmacology (2007) 2.39
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proc Natl Acad Sci U S A (2004) 2.32
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology (Berl) (2003) 2.28
Effects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology (2001) 2.18
Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons. J Pharmacol Exp Ther (2004) 1.97
On the cerebral accumulation of ketamine and the relationship between metabolism of the drug and its pharmacological effects. J Pharmacol Exp Ther (1974) 1.97
Distribution in the brain and metabolism of ketamine in the rat after intravenous administration. Anesthesiology (1973) 1.74
Mechanism of action of memantine. Curr Opin Pharmacol (2005) 1.74
Ketamine. Handb Exp Pharmacol (2008) 1.72
Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine. J Neurosci (2009) 1.72
NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci (1996) 1.58
The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence. Int J Geriatr Psychiatry (2003) 1.50
Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET). Eur Neuropsychopharmacol (1997) 1.49
Trapping channel block of NMDA-activated responses by amantadine and memantine. J Neurophysiol (1997) 1.46
The acute effects of NMDA antagonism: from the rodent to the human brain. Brain Res Rev (2008) 1.43
The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev (2003) 1.40
Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia. Hippocampus (2001) 1.35
Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacology (1995) 1.34
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J Physiol (2007) 1.34
Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels. J Pharmacol Exp Ther (2005) 1.31
Low doses of memantine disrupt memory in adult rats. J Neurosci (2006) 1.27
Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose. Proc Natl Acad Sci U S A (1996) 1.26
Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. Br J Pharmacol (2001) 1.20
Locomotor response to novelty predicts a rat's propensity to self-administer nicotine. Psychopharmacology (Berl) (2001) 1.15
Interaction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors. Pharmacol Toxicol (1995) 1.10
A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory. Psychopharmacology (Berl) (2011) 1.09
Diverse and often opposite behavioural effects of NMDA receptor antagonists in rats: implications for "NMDA antagonist modelling" of schizophrenia. Psychopharmacology (Berl) (2009) 1.07
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine. Behav Pharmacol (2006) 1.04
Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons. Eur J Pharmacol (1992) 1.02
Memantine binding to a superficial site on NMDA receptors contributes to partial trapping. J Physiol (2009) 1.01
Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane. Pharmacol Biochem Behav (2006) 1.00
Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics. Mol Psychiatry (2005) 1.00
Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block. J Pharmacol Exp Ther (1999) 0.99
Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors. Br J Pharmacol (2003) 0.96
Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Drug Metab Dispos (2004) 0.95
Two blocking sites of amino-adamantane derivatives in open N-methyl-D-aspartate channels. Biophys J (1998) 0.94
A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists. Psychopharmacology (Berl) (2010) 0.94
Anti-dementia drugs and hippocampal-dependent memory in rodents. Behav Pharmacol (2007) 0.93
Comparative pharmacology of the optical isomers of ketamine in mice. Eur J Pharmacol (1978) 0.90
Memantine agonist action at dopamine D2High receptors. Synapse (2008) 0.89
The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats. Neuropsychopharmacology (2006) 0.88
Ketamine for pain: an update of uses in palliative care. J Palliat Med (2012) 0.87
Glutamate antagonists have different effects on spontaneous locomotor activity in rats. Pharmacol Biochem Behav (1994) 0.87
Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers. Anesthesiology (2002) 0.86
On the pharmacology of the ketamine enantiomorphs in the rat. J Pharmacol Exp Ther (1977) 0.85
Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat--a pharmacokinetic microdialysis study. Eur J Pharmacol (1994) 0.84
Biodisposition of ketamine in the rat: self-induction of metabolism. J Pharmacol Exp Ther (1976) 0.84
Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology (1996) 0.84
Effects of halothane anesthesia on the biodisposition of ketamine in rats. J Pharmacol Exp Ther (1976) 0.84
Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats. Behav Pharmacol (2008) 0.82
Effects of ketamine on tunnel maze and water maze performance in the rat. Behav Neural Biol (1989) 0.82
The uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine prolongs spatial memory in a rat delayed radial-arm maze memory task. Eur J Pharmacol (2007) 0.80
The stereoselective effects of ketamine isomers on heteromeric N-methyl-D-aspartate receptor channels. Anesth Analg (2000) 0.80
Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats. J Neural Transm (Vienna) (1999) 0.79
Brain distribution of an uncompetitive NMDA receptor antagonist; comparison to its in vitro potency in electrophysiological studies. Naunyn Schmiedebergs Arch Pharmacol (1999) 0.78
Ketamine-induced locomotion in rats in an open-field. Pharmacol Biochem Behav (1985) 0.78
The in vivo relevance of the varied channel-blocking properties of uncompetitive NMDA antagonists: tests on spinal neurones. Neuropharmacology (2001) 0.77
Pharmacokinetics of memantine in rats and mice. PLoS Curr (2011) 0.77
Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature (2009) 2.64
Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine. J Neurosci (2009) 1.72
Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. Neuron (2008) 1.67
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol Learn Mem (2006) 1.32
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci (2005) 1.24
NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock. J Neurosci (2006) 1.22
Loss of the tailless gene affects forebrain development and emotional behavior. Physiol Behav (2002) 1.19
A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Nat Neurosci (2012) 1.18
Voltage-dependent gating of NR1/2B NMDA receptors. J Physiol (2008) 1.12
Cue-elicited reward-seeking requires extracellular signal-regulated kinase activation in the nucleus accumbens. J Neurosci (2008) 1.08
Early maintenance of hippocampal mossy fiber--long-term potentiation depends on protein and RNA synthesis and presynaptic granule cell integrity. J Neurosci (2003) 1.06
Memantine binding to a superficial site on NMDA receptors contributes to partial trapping. J Physiol (2009) 1.01
NR2 subunit-dependence of NMDA receptor channel block by external Mg2+. J Physiol (2004) 1.00
Modulation by permeant ions of Mg(2+) inhibition of NMDA-activated whole-cell currents in rat cortical neurons. J Physiol (2002) 0.96
Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors. J Neurosci (2006) 0.95
Protein phosphatases 1 and 2A are both required for long-term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo. Hippocampus (2010) 0.95
Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons. J Neurophysiol (2012) 0.95
Molecular bases of NMDA receptor subtype-dependent properties. J Physiol (2014) 0.91
Superoxide dismutase and hippocampal function: age and isozyme matter. Antioxid Redox Signal (2007) 0.89
Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation. Organogenesis (2014) 0.86
Channel gating of NMDA receptors. Physiol Behav (2002) 0.86
Evaluation of the lower spine after blunt trauma using abdominal computed tomographic scanning supplemented with lateral scanograms. J Trauma (2002) 0.86
Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock. J Neurosci (2013) 0.85
Appetitive Pavlovian conditioned stimuli increase CREB phosphorylation in the nucleus accumbens. Neurobiol Learn Mem (2009) 0.85
LTP- and LTD-inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo. Hippocampus (2010) 0.83
HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation. Mol Ther (2010) 0.81
Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI. Neurobiol Learn Mem (2013) 0.80
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons. J Neurosci (2010) 0.80
Stimulus-specific and differential distribution of activated extracellular signal-regulated kinase in the nucleus accumbens core and shell during Pavlovian-instrumental transfer. Brain Struct Funct (2012) 0.78
Properties and functional implications of I (h) in hippocampal area CA3 interneurons. Pflugers Arch (2011) 0.77
Flipping the switch from electrical to chemical communication. Nat Neurosci (2005) 0.77
Whole-cell patch-clamp analysis of recombinant NMDA receptor pharmacology using brief glutamate applications. Methods Mol Biol (2014) 0.76