Published in ChemMedChem on May 13, 2013
Highlights of the Latest Advances in Research on CDK Inhibitors. Cancers (Basel) (2014) 0.94
Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities. Bioorg Med Chem Lett (2015) 0.78
A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature). Sci Rep (2017) 0.75
Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides. Angew Chem Int Ed Engl (2016) 0.75
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell (2007) 2.38
In vitro demonstration of anaerobic oxidation of methane coupled to sulphate reduction in sediment from a marine gas hydrate area. Environ Microbiol (2002) 2.23
Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response. Blood (2006) 1.93
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem (2002) 1.62
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci (2013) 1.62
Environmental regulation of the anaerobic oxidation of methane: a comparison of ANME-I and ANME-II communities. Environ Microbiol (2005) 1.54
Characterization, outcome, and prognosis in 273 patients with primary sclerosing cholangitis: A single center study. Am J Gastroenterol (2006) 1.36
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Cancer Res (2008) 1.29
Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors. J Hepatol (2005) 1.24
CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol (2010) 1.21
Imaging properties of small-pixel spectroscopic x-ray detectors based on cadmium telluride sensors. Phys Med Biol (2012) 1.21
The chemistry and biology of soluble guanylate cyclase stimulators and activators. Angew Chem Int Ed Engl (2013) 1.18
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem (2012) 1.17
Microbiological investigation of methane- and hydrocarbon-discharging mud volcanoes in the Carpathian Mountains, Romania. Environ Microbiol (2006) 1.15
Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat Neurosci (2012) 1.15
Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A (2012) 1.14
Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits. Drug Discov Today (2006) 1.14
Methane cycling in lake sediments and its influence on chironomid larval delta13C. FEMS Microbiol Ecol (2005) 1.13
Differential regulation of in vivo angiogenesis by angiotensin II receptors. FASEB J (2003) 1.12
Transplantation of human islets without immunosuppression. Proc Natl Acad Sci U S A (2013) 1.10
A probabilistic approach to classifying metabolic stability. J Chem Inf Model (2008) 1.10
Cooccurrence of aerobic and anaerobic methane oxidation in the water column of Lake Plusssee. Appl Environ Microbiol (2005) 1.10
A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem (2010) 1.07
Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis. Ann Rheum Dis (2010) 1.06
Comparing field and microcosm experiments: a case study on methano- and methylo-trophic bacteria in paddy soil. FEMS Microbiol Ecol (2004) 1.05
Substantial improvements in large-scale redocking and screening using the novel HYDE scoring function. J Comput Aided Mol Des (2011) 1.04
Tau oligomers impair artificial membrane integrity and cellular viability. J Biol Chem (2012) 1.03
High calorie diet triggers hypothalamic angiopathy. Mol Metab (2012) 1.01
Impact of isotype-selective estrogen receptor agonists on ovarian function. Proc Natl Acad Sci U S A (2004) 1.01
Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res Int (2013) 0.97
Enhanced gene detection assays for fumarate-adding enzymes allow uncovering of anaerobic hydrocarbon degraders in terrestrial and marine systems. Appl Environ Microbiol (2012) 0.95
Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors. Bioorg Med Chem Lett (2005) 0.95
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases. Neuro Oncol (2008) 0.95
Acetogens and acetoclastic methanosarcinales govern methane formation in abandoned coal mines. Appl Environ Microbiol (2011) 0.94
Structure of an F430 variant from archaea associated with anaerobic oxidation of methane. J Am Chem Soc (2008) 0.94
Drug resistance in epilepsy: the role of the blood-brain barrier. Novartis Found Symp (2002) 0.93
Bacterial enzymes for dissimilatory sulfate reduction in a marine microbial mat (Black Sea) mediating anaerobic oxidation of methane. Environ Microbiol (2011) 0.92
In silico ADMET traffic lights as a tool for the prioritization of HTS hits. ChemMedChem (2006) 0.92
Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery. J Biomol Screen (2006) 0.92
Geographic distribution and relative abundance of the sibling vector species Culex torrentium and Culex pipiens in Sweden. Vector Borne Zoonotic Dis (2011) 0.91
CypScore: Quantitative prediction of reactivity toward cytochromes P450 based on semiempirical molecular orbital theory. ChemMedChem (2009) 0.91
Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats. Drug Metab Dispos (2008) 0.90
Mechanism-based inhibition: deriving K(I) and k(inact) directly from time-dependent IC(50) values. J Biomol Screen (2009) 0.89
Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis. Scand J Gastroenterol (2006) 0.89
BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application. Mol Cancer Ther (2012) 0.89
N-glycosylation of ABC transporters is associated with functional activity in sandwich-cultured rat hepatocytes. Eur J Pharm Sci (2010) 0.88
Biosynthesis of hopanoids by sulfate-reducing bacteria (genus Desulfovibrio). Environ Microbiol (2006) 0.88
Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines? Angew Chem Int Ed Engl (2011) 0.88
Methanogenic capabilities of ANME-archaea deduced from (13) C-labelling approaches. Environ Microbiol (2013) 0.87
Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea. FEBS J (2007) 0.86
Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. Clin Cancer Res (2004) 0.86
Radiofluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid as inhibitors of prostate specific membrane antigen (PSMA) for the imaging of prostate cancer. J Med Chem (2012) 0.85
Functional characterisation of nucleoside transport in rat brain endothelial cells. Neuroreport (2003) 0.85
Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study. BMC Gastroenterol (2007) 0.85
Successful treatment of a patient with HER2-positive metastatic gastric cancer with third-line combination therapy with irinotecan, 5-fluorouracil, leucovorin and trastuzumab (FOLFIRI-T). Onkologie (2011) 0.85
Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells. J Neuroimmunol (2006) 0.84
Cephalostatin analogues--synthesis and biological activity. Fortschr Chem Org Naturst (2004) 0.84
Off-target decoding of a multitarget kinase inhibitor by chemical proteomics. Chembiochem (2009) 0.84
Accelerated methanogenesis from aliphatic and aromatic hydrocarbons under iron- and sulfate-reducing conditions. FEMS Microbiol Lett (2010) 0.83
A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors. Acta Crystallogr D Biol Crystallogr (2011) 0.83
Anaerobic Oxidation of Methane at a Marine Methane Seep in a Forearc Sediment Basin off Sumatra, Indian Ocean. Front Microbiol (2011) 0.83
Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases. Exp Dermatol (2011) 0.82
Facing the challenges of structure-based target prediction by inverse virtual screening. J Chem Inf Model (2014) 0.82
Quantitative analysis of coenzyme F430 in environmental samples: a new diagnostic tool for methanogenesis and anaerobic methane oxidation. Anal Chem (2014) 0.82
Microbial community changes at a terrestrial volcanic CO2 vent induced by soil acidification and anaerobic microhabitats within the soil column. FEMS Microbiol Ecol (2012) 0.82
Progress in the identification of stroke-related genes: emerging new possibilities to develop concepts in stroke therapy. CNS Drugs (2005) 0.82
Utility of protein structures in overcoming ADMET-related issues of drug-like compounds. Drug Discov Today (2011) 0.82
Best of both worlds: combining pharma data and state of the art modeling technology to improve in Silico pKa prediction. J Chem Inf Model (2014) 0.82
Local interactions influence the fibrillation kinetics, structure and dynamics of Aβ(1-40) but leave the general fibril structure unchanged. Phys Chem Chem Phys (2014) 0.81
Effects of CO2 on benthic biota: an in situ benthic chamber experiment in Storfjorden (Norway). Mar Pollut Bull (2013) 0.81
Conception and pharmacodynamic profile of drospirenone. Steroids (2003) 0.81
Fluorescence resonance energy transfer studies of U-shaped DNA molecules. J Biotechnol (2002) 0.81
Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery. Chem Biodivers (2005) 0.81
Sulfoximines: a neglected opportunity in medicinal chemistry. Angew Chem Int Ed Engl (2013) 0.81
From rigidity to conformational flexibility: macrocyclic templates derived from ansa-steroids. Angew Chem Int Ed Engl (2003) 0.80
Flexsim-R: a virtual affinity fingerprint descriptor to calculate similarities of functional groups. J Comput Aided Mol Des (2002) 0.80
Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats. Drug Metab Dispos (2008) 0.80
Mining high-throughput screening data of combinatorial libraries: development of a filter to distinguish hits from nonhits. J Chem Inf Comput Sci (2004) 0.80
Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment. J Mol Microbiol Biotechnol (2016) 0.80
Interaction of nucleoside analogues with nucleoside transporters in rat brain endothelial cells. J Drug Target (2004) 0.79
From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors. Chembiochem (2005) 0.79
Viability and adaptation potential of indigenous microorganisms from natural gas field fluids in high pressure incubations with supercritical CO2. Environ Sci Technol (2014) 0.79
Molecular basis of the interaction specificity between the human glucocorticoid receptor and its endogenous steroid ligand cortisol. Chembiochem (2005) 0.79
Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells. Transl Oncol (2008) 0.79
Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban). Curr Top Med Chem (2010) 0.79
Equilibrium, 1H and 13C NMR spectroscopy, and X-ray diffraction studies on the complexes Bi(DOTA)- and Bi(DO3A-Bu). Inorg Chem (2003) 0.78
Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles. Eur J Pharm Biopharm (2010) 0.78
Relevance of deep-subsurface microbiology for underground gas storage and geothermal energy production. Adv Biochem Eng Biotechnol (2014) 0.78
Starting up microbial enhanced oil recovery. Adv Biochem Eng Biotechnol (2014) 0.78
Ultrafast de novo docking combining pharmacophores and combinatorics. J Comput Aided Mol Des (2007) 0.77