Published in Zebrafish on May 17, 2013
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands | NCT01351103
Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer. Cells (2014) 0.89
Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion. Cells (2014) 0.76
Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis. Biol Open (2015) 0.76
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
Animal models of human disease: zebrafish swim into view. Nat Rev Genet (2007) 8.36
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol (2011) 7.05
Vertebrate genome evolution and the zebrafish gene map. Nat Genet (1998) 5.16
The zebrafish gene map defines ancestral vertebrate chromosomes. Genome Res (2005) 3.18
Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet (2004) 3.09
Targeting protein prenylation for cancer therapy. Nat Rev Cancer (2011) 2.60
Developmental biology of the pancreas: a comprehensive review. Dev Biol (2008) 2.59
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev (2005) 2.44
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol (2010) 2.25
Experimental conversion of liver to pancreas. Curr Biol (2003) 2.24
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development (2004) 2.21
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet (2007) 2.14
Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Dev Biol (2003) 2.10
Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev Biol (2001) 2.04
RNA polymerases I and III, non-coding RNAs and cancer. Trends Genet (2008) 1.91
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90
Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol Ther (2009) 1.85
Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res (2009) 1.66
Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res (2006) 1.62
Pancreatic development and disease. Gastroenterology (2007) 1.62
Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Dev Biol (2004) 1.60
Mutations affecting development of zebrafish digestive organs. Development (1996) 1.58
Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biol (2007) 1.54
Early pattern of differentiation in the human pancreas. Diabetes (2000) 1.53
Exocrine pancreas development in zebrafish. Dev Biol (2005) 1.51
Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology (1998) 1.46
Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol Cell (2004) 1.42
Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. J Clin Endocrinol Metab (2003) 1.41
Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol (2009) 1.40
Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One (2011) 1.39
Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Dev Biol (2007) 1.38
Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J Biol Chem (2002) 1.37
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology (2008) 1.36
Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol (2004) 1.36
New school in liver development: lessons from zebrafish. Hepatology (2009) 1.36
Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp Cell Res (2006) 1.28
TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development (2009) 1.28
Nil per os encodes a conserved RNA recognition motif protein required for morphogenesis and cytodifferentiation of digestive organs in zebrafish. Development (2003) 1.27
Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes Dev (2008) 1.26
Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (2012) 1.22
Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis (2001) 1.21
Mouse models of pancreatic cancer. World J Gastroenterol (2012) 1.20
Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet (2008) 1.19
Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation. Pediatr Diabetes (2009) 1.18
Cell biology. The unusual case of Porcupine. Science (2012) 1.14
Zebrafish pancreas development. Mol Cell Endocrinol (2009) 1.10
Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Dis Model Mech (2010) 1.09
Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn (2003) 1.07
Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development. Development (2007) 1.07
Origin of the zebrafish endocrine and exocrine pancreas. Dev Dyn (2007) 1.05
Organ-specific requirements for Hdac1 in liver and pancreas formation. Dev Biol (2008) 1.04
Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer Lett (2010) 1.04
Anatomical and histological observation on the pancreas in adult zebrafish. Pancreas (2007) 1.00
TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm. Dev Biol (2006) 0.98
Two lamprey Hedgehog genes share non-coding regulatory sequences and expression patterns with gnathostome Hedgehogs. PLoS One (2010) 0.96
Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. PLoS Biol (2008) 0.95
Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Lett (2011) 0.93
Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol Ther (2010) 0.92
Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome. Cancer Biol Ther (2003) 0.91
Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells. Cancer Biol Ther (2012) 0.90
TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther (2012) 0.87
Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer Biol Ther (2011) 0.86
Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas. Mol Biol Cell (2012) 0.86
TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets. Scientifica (Cairo) (2012) 0.85
Zebrafish as a model for pancreatic cancer research. Methods Mol Med (2005) 0.85
The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics (2000) 0.84
Endocrine pancreas development in zebrafish. Cell Cycle (2011) 0.84
Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype. Adv Exp Med Biol (2013) 0.82
Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open (2012) 0.81
The roles of the PDZ-containing proteins bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass. Curr Protein Pept Sci (2009) 0.78
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr (2008) 1.77
Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice. PLoS One (2012) 1.02
Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. J Cell Biochem (2010) 1.02
Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Lett (2011) 0.93
TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther (2012) 0.87
Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Am J Physiol Cell Physiol (2012) 0.87
TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets. Scientifica (Cairo) (2012) 0.85
Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Am J Physiol Endocrinol Metab (2013) 0.84
Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open (2012) 0.81
Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes. World J Biol Chem (2012) 0.80
Salutary effect of aurintricarboxylic acid on endotoxin- and sepsis-induced changes in muscle protein synthesis and inflammation. Shock (2014) 0.79
Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon. Biochem Biophys Res Commun (2013) 0.75
Current Systemic Treatment and Emerging Therapeutic Strategies in Pancreatic Adenocarcinoma. Curr Clin Pharmacol (2015) 0.75