PubRank

Gary D Lopaschuk

Author PubWeight™ 165.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008 9.74
2 A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007 9.20
3 Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005 6.06
4 The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest 2002 4.22
5 AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol 2006 2.09
6 Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension. Sci Transl Med 2010 2.04
7 Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes 2010 1.97
8 The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. J Mol Med (Berl) 2009 1.94
9 Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 2002 1.82
10 Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia. Circ Res 2006 1.71
11 Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation 2002 1.65
12 Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity. Am J Physiol Renal Physiol 2014 1.64
13 Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A 2007 1.61
14 Energy metabolism in the hypertrophied heart. Heart Fail Rev 2002 1.58
15 Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. J Lipid Res 2004 1.58
16 Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity. Circulation 2009 1.55
17 Accelerated rates of glycolysis in the hypertrophied heart: are they a methodological artifact? Am J Physiol Endocrinol Metab 2002 1.54
18 Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot Essent Fatty Acids 2004 1.51
19 Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. Cardiovasc Res 2011 1.49
20 Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart. Biochim Biophys Acta 2011 1.48
21 Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 2002 1.46
22 Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase. J Biol Chem 2004 1.36
23 Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am J Physiol Heart Circ Physiol 2009 1.36
24 Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle. Biochim Biophys Acta 2009 1.32
25 A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem 2001 1.29
26 AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart. Prog Lipid Res 2003 1.28
27 Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice. Diabetes 2012 1.26
28 Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation 2004 1.23
29 Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol 2005 1.22
30 Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation 2006 1.21
31 Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. Hypertension 2009 1.19
32 Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. Cardiovasc Res 2012 1.18
33 Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes 2009 1.16
34 Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice. Cardiovasc Res 2009 1.15
35 Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. Circulation 2009 1.13
36 High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 2002 1.13
37 Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology 2005 1.12
38 Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem 2011 1.11
39 Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat. Hypertension 2010 1.11
40 Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients. FASEB J 2007 1.09
41 Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochim Biophys Acta 2013 1.09
42 Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res 2004 1.08
43 Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease. Am J Physiol Endocrinol Metab 2012 1.06
44 Optimization of cardiac metabolism in heart failure. Curr Pharm Des 2011 1.05
45 Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circ Heart Fail 2013 1.05
46 Alterations in energy metabolism in cardiomyopathies. Ann Med 2007 1.04
47 FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl) 2012 1.03
48 Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis 2013 1.02
49 Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res 2006 1.02
50 Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction. Circ Heart Fail 2012 1.02
51 Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia/reperfusion. Cardiovasc Res 2010 1.00
52 Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy. Am J Physiol Heart Circ Physiol 2006 1.00
53 Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A 2011 1.00
54 Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs. Am J Physiol Endocrinol Metab 2002 0.99
55 ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. Am J Physiol Heart Circ Physiol 2013 0.98
56 Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction. Am J Physiol Heart Circ Physiol 2010 0.98
57 Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts. Am J Physiol Heart Circ Physiol 2009 0.97
58 Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats. Am J Physiol Endocrinol Metab 2002 0.96
59 Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation. Circ Heart Fail 2014 0.96
60 Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids. J Nucl Med 2006 0.96
61 Pyridine nucleotide regulation of cardiac intermediary metabolism. Circ Res 2012 0.96
62 Targeting mitochondrial oxidative metabolism as an approach to treat heart failure. Biochim Biophys Acta 2012 0.96
63 The malonyl CoA axis as a potential target for treating ischaemic heart disease. Cardiovasc Res 2008 0.95
64 Malonyl CoA control of fatty acid oxidation in the ischemic heart. J Mol Cell Cardiol 2002 0.95
65 Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation. Cardiovasc Res 2013 0.94
66 Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation. Cardiovasc Res 2010 0.94
67 Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochim Biophys Acta 2010 0.93
68 Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells. Am J Physiol Endocrinol Metab 2010 0.92
69 Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique. Eur J Biochem 2004 0.91
70 Effects of high intensity exercise on biventricular function assessed by cardiac magnetic resonance imaging in endurance trained and normally active individuals. Am J Cardiol 2010 0.91
71 Calreticulin induces dilated cardiomyopathy. PLoS One 2013 0.90
72 Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion. Basic Res Cardiol 2009 0.90
73 Signalling in cardiac metabolism. Cardiovasc Res 2008 0.90
74 Metabolic modulation: a means to mend a broken heart. Circulation 2002 0.89
75 Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. PLoS One 2012 0.88
76 Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy. Toxicology 2010 0.88
77 gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. J Biol Chem 2004 0.87
78 Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation. J Mol Cell Cardiol 2008 0.87
79 Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice. Am J Physiol Heart Circ Physiol 2003 0.86
80 Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice. J Biol Chem 2004 0.86
81 Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia. Am J Physiol Heart Circ Physiol 2005 0.86
82 beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. Am J Physiol Heart Circ Physiol 2003 0.86
83 Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK. J Mol Cell Cardiol 2008 0.86
84 Hypothalamic malonyl-CoA and the control of food intake. Physiol Behav 2013 0.86
85 Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure. J Mol Cell Cardiol 2013 0.86
86 Alpha-catalytic subunits of 5'AMP-activated protein kinase display fiber-specific expression and are upregulated by chronic low-frequency stimulation in rat muscle. Am J Physiol Regul Integr Comp Physiol 2007 0.85
87 Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation. Am J Physiol Heart Circ Physiol 2007 0.85
88 Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power. Am J Physiol Heart Circ Physiol 2005 0.85
89 H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation. J Mol Cell Cardiol 2008 0.85
90 Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. J Med Chem 2006 0.85
91 Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts. Can J Physiol Pharmacol 2004 0.84
92 AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts. Am J Physiol Heart Circ Physiol 2002 0.84
93 Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload. Cardiovasc Res 2012 0.84
94 Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy. Circ Res 2012 0.83
95 Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles. Can J Physiol Pharmacol 2003 0.83
96 High levels of fatty acids increase contractile function of neonatal rabbit hearts during reperfusion following ischemia. Am J Physiol Heart Circ Physiol 2010 0.83
97 Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation: CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift. Anesthesiology 2010 0.83
98 Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2. FEBS J 2012 0.83
99 Regulation of malonyl-CoA concentration and turnover in the normal heart. J Biol Chem 2004 0.83
100 Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts. Am J Physiol Heart Circ Physiol 2010 0.83
101 Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res 2016 0.82
102 Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart. Pediatr Res 2008 0.82
103 The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study. BMC Cardiovasc Disord 2014 0.82
104 Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei. Physiol Behav 2013 0.82
105 Metabolic therapy for the treatment of ischemic heart disease: reality and expectations. Expert Rev Cardiovasc Ther 2007 0.82
106 Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis. Curr Atheroscler Rep 2005 0.82
107 Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding. FEBS Lett 2012 0.82
108 Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle. Am J Physiol Endocrinol Metab 2009 0.81
109 Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart. Am J Physiol Heart Circ Physiol 2002 0.81
110 Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action. J Biol Chem 2012 0.81
111 ApoA-1 infusion reduces arterial cholesterol and myocardial lesions in a rat model of cardiac dysfunction and insulin resistance. Atherosclerosis 2012 0.81
112 Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J Med Chem 2006 0.81
113 Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a. Am J Physiol Regul Integr Comp Physiol 2011 0.81
114 Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance. Am J Physiol Endocrinol Metab 2012 0.81
115 Elevated levels of activated NHE1 protect the myocardium and improve metabolism following ischemia/reperfusion injury. J Mol Cell Cardiol 2010 0.80
116 Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization. Eur J Heart Fail 2005 0.80
117 Substantial working muscle glycerol turnover during two-legged cycle ergometry. Am J Physiol Endocrinol Metab 2007 0.79
118 Anti-anginal effects of partial fatty acid oxidation inhibitors. Curr Opin Pharmacol 2007 0.79
119 Chronic central leptin decreases food intake and improves glucose tolerance in diet-induced obese mice independent of hypothalamic malonyl CoA levels and skeletal muscle insulin sensitivity. Endocrinology 2011 0.79
120 Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1. J Thorac Cardiovasc Surg 2013 0.78
121 5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes. Can J Physiol Pharmacol 2014 0.78
122 Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet. J Cardiovasc Pharmacol 2011 0.78
123 Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake. Am J Physiol Endocrinol Metab 2013 0.77
124 MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes 2002 0.77
125 Cardiac energy metabolism alterations in angiotensin II induced hypertrophy. J Mol Cell Cardiol 2006 0.77
126 High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency. J Mol Cell Cardiol 2009 0.77
127 A role for period 2 in cardioprotection. Cell Metab 2012 0.77
128 An ACE up your sleeve: 2 is better than 1. Circ Res 2012 0.77
129 HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity. Mol Endocrinol 2013 0.77
130 Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. J Pharmacol Exp Ther 2014 0.76
131 Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett 2006 0.76
132 Cardiac hypertrophy in the newborn delays the maturation of fatty acid β-oxidation and compromises postischemic functional recovery. Am J Physiol Heart Circ Physiol 2012 0.76
133 Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts. Basic Res Cardiol 2007 0.76
134 Malonyl CoA: A promising target for the treatment of cardiac disease. IUBMB Life 2014 0.76
135 Glutamate transport in the heart: lessons learned from the brain. J Mol Cell Cardiol 2004 0.75
136 Cardiac insulin resistance: it's sweeter than you think. Endocrinology 2013 0.75
137 Plasma fatty acid levels in children during extracorporeal membrane oxygenation support--a pilot study. J Extra Corpor Technol 2013 0.75
138 Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets. Mol Cell Biochem 2008 0.75
139 Expression, purification, and characterization of human malonyl-CoA decarboxylase. Protein Expr Purif 2004 0.75
140 Hypoxia-induced adaptation to mitral regurgitation: a role for K ATP channel up-regulation? J Am Coll Cardiol 2011 0.75
141 Something old holds potential to be something new in heart failure: allopurinol revisited. Can J Cardiol 2012 0.75
142 Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun 2017 0.75