Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
|
J Biol Chem
|
2009
|
12.73
|
2
|
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
|
Nature
|
2008
|
6.80
|
3
|
MEK1 mutations confer resistance to MEK and B-RAF inhibition.
|
Proc Natl Acad Sci U S A
|
2009
|
6.58
|
4
|
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
|
Cancer Discov
|
2011
|
4.80
|
5
|
In situ kinase profiling reveals functionally relevant properties of native kinases.
|
Chem Biol
|
2011
|
2.69
|
6
|
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
|
J Med Chem
|
2010
|
2.00
|
7
|
Discovery of potent and selective covalent inhibitors of JNK.
|
Chem Biol
|
2012
|
1.55
|
8
|
Conformational disturbance in Abl kinase upon mutation and deregulation.
|
Proc Natl Acad Sci U S A
|
2009
|
1.47
|
9
|
A structure-guided approach to creating covalent FGFR inhibitors.
|
Chem Biol
|
2010
|
1.46
|
10
|
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
|
Nat Biotechnol
|
2013
|
1.33
|
11
|
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.
|
Blood
|
2010
|
1.32
|
12
|
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.
|
Cancer Discov
|
2013
|
1.27
|
13
|
A complex network of factors with overlapping affinities represses splicing through intronic elements.
|
Nat Struct Mol Biol
|
2012
|
1.26
|
14
|
Origin of new genes: evidence from experimental and computational analyses.
|
Genetica
|
2003
|
1.24
|
15
|
Cadmium and zinc interactions and their transfer in soil-crop system under actual field conditions.
|
Sci Total Environ
|
2002
|
1.18
|
16
|
Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.
|
Bioorg Med Chem Lett
|
2008
|
1.17
|
17
|
Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.
|
Biochim Biophys Acta
|
2010
|
1.16
|
18
|
Allosteric interactions between the myristate- and ATP-site of the Abl kinase.
|
PLoS One
|
2011
|
1.12
|
19
|
Detection of adenosine triphosphate with an aptamer biosensor based on surface-enhanced Raman scattering.
|
Anal Chem
|
2012
|
1.00
|
20
|
Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation.
|
Clin Cancer Res
|
2012
|
0.99
|
21
|
Shape-dependent surface-enhanced Raman scattering in gold-Raman probe-silica sandwiched nanoparticles for biocompatible applications.
|
Nanotechnology
|
2012
|
0.98
|
22
|
Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma.
|
ACS Nano
|
2013
|
0.98
|
23
|
A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.
|
J Med Chem
|
2010
|
0.96
|
24
|
Product-state-resolved dynamics of the elementary reaction of atomic oxygen with molecular hydrogen, O(³P) + D₂ → OD(X²Π) + D.
|
Nat Chem
|
2013
|
0.94
|
25
|
Polyaniline nanowires on Si surfaces fabricated with DNA templates.
|
J Am Chem Soc
|
2004
|
0.94
|
26
|
Separation of peptides with polyionic nanosponges for MALDI-MS analysis.
|
Langmuir
|
2009
|
0.90
|
27
|
Prevalence of HIV and syphilis infection among high school and college student MSM in China: a systematic review and meta-analysis.
|
PLoS One
|
2013
|
0.90
|
28
|
Constitutional mutation of keratin 13 gene in familial white sponge nevus.
|
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
|
2003
|
0.90
|
29
|
Grayscale photomask fabricated by laser direct writing in metallic nano-films.
|
Opt Express
|
2009
|
0.90
|
30
|
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
|
J Pathol
|
2013
|
0.89
|
31
|
A dibutyl phthalate sensor based on a nanofiber polyaniline coated quartz crystal monitor.
|
Sensors (Basel)
|
2013
|
0.88
|
32
|
Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells.
|
PLoS One
|
2013
|
0.88
|
33
|
Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).
|
J Med Chem
|
2014
|
0.87
|
34
|
Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.
|
J Orthop Res
|
2014
|
0.86
|
35
|
Exploiting Surroundedness for Saliency Detection: A Boolean Map Approach.
|
IEEE Trans Pattern Anal Mach Intell
|
2015
|
0.84
|
36
|
Discovery and characterization of novel mutant FLT3 kinase inhibitors.
|
Mol Cancer Ther
|
2010
|
0.84
|
37
|
Complete state-resolved non-adiabatic dynamics of the O((3)P) + D2 → OD(X(2)Π) + D reaction.
|
J Am Chem Soc
|
2014
|
0.83
|
38
|
Expanding the diversity of allosteric bcr-abl inhibitors.
|
J Med Chem
|
2010
|
0.83
|
39
|
Epitaxial crystallization of isotactic poly(methyl methacrylate) on highly oriented polyethylene.
|
J Phys Chem B
|
2006
|
0.82
|
40
|
Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.
|
Chem Biol
|
2012
|
0.81
|
41
|
In situ electrodeposited nanoparticles for facilitating electron transfer across self-assembled monolayers in biosensor design.
|
Talanta
|
2007
|
0.81
|
42
|
Broad spectrum alkynyl inhibitors of T315I Bcr-Abl.
|
Bioorg Med Chem Lett
|
2010
|
0.81
|
43
|
Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors.
|
ACS Med Chem Lett
|
2011
|
0.80
|
44
|
Remarkably enhanced photocatalytic activity of laser ablated Au nanoparticle decorated BiFeO3 nanowires under visible-light.
|
Chem Commun (Camb)
|
2013
|
0.80
|
45
|
Molecular orientation and field-effect transistors of a rigid rod conjugated polymer thin films.
|
J Phys Chem B
|
2009
|
0.80
|
46
|
Fluorescent visualization of Src by using dasatinib-BODIPY.
|
Chembiochem
|
2014
|
0.78
|
47
|
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit.
|
Bioorg Med Chem Lett
|
2012
|
0.78
|
48
|
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
|
BMC Cancer
|
2014
|
0.78
|
49
|
Light polarization-controlled shape-memory polymer/gold nanorod composite.
|
Macromol Rapid Commun
|
2013
|
0.78
|
50
|
Beam-surface scattering studies of the individual and combined effects of VUV radiation and hyperthermal O, O2, or Ar on FEP Teflon surfaces.
|
ACS Appl Mater Interfaces
|
2009
|
0.78
|
51
|
Crossed-beams and theoretical studies of the O((3)P) + H(2)O --> HO(2) + H reaction excitation function.
|
J Phys Chem A
|
2007
|
0.78
|
52
|
Development of ATP-competitive mTOR inhibitors.
|
Methods Mol Biol
|
2012
|
0.78
|
53
|
The expression and bioinformatic analysis of a novel gene C20orf14 associated with lymphoma.
|
J Huazhong Univ Sci Technolog Med Sci
|
2008
|
0.78
|
54
|
A putative gene sbe3-rs for resistant starch mutated from SBE3 for starch branching enzyme in rice (Oryza sativa L.).
|
PLoS One
|
2012
|
0.78
|
55
|
A green and facile approach for the synthesis of water-dispersible reduced graphene oxide based on ionic liquids.
|
Chem Commun (Camb)
|
2014
|
0.77
|
56
|
Development of 'DFG-out' inhibitors of gatekeeper mutant kinases.
|
Bioorg Med Chem Lett
|
2012
|
0.77
|
57
|
3-(10-Chloro-9-anthr-yl)-5-[3-(prop-2-yn-yloxy)phenoxy-meth-yl]isoxazole.
|
Acta Crystallogr Sect E Struct Rep Online
|
2009
|
0.75
|
58
|
Bis(N,N-dimethyl-formamide-κO)bis-(1-methyl-imidazole-2-carbaldehyde oximato-κN,O)manganese(III) perchlorate.
|
Acta Crystallogr Sect E Struct Rep Online
|
2008
|
0.75
|
59
|
Miscibility and hydrogen-bonding interactions in biodegradable polymer blends of poly(3-hydroxybutyrate) and a partially hydrolyzed poly(vinyl alcohol).
|
J Phys Chem B
|
2005
|
0.75
|
60
|
Atomic oxygen effects on POSS polyimides in low earth orbit.
|
ACS Appl Mater Interfaces
|
2012
|
0.75
|
61
|
Risk factors of central lymph node metastasis of papillary thyroid carcinoma: A single-center retrospective analysis of 3273 cases.
|
Medicine (Baltimore)
|
2017
|
0.75
|
62
|
Syntheses, structures and properties of a series of non-heme alkoxide-Fe(III) complexes of a benzimidazolyl-rich ligand as models for lipoxygenase.
|
Dalton Trans
|
2011
|
0.75
|
63
|
Tuning the iridescence of chiral nematic cellulose nanocrystal films with a vacuum-assisted self-assembly technique.
|
Biomacromolecules
|
2014
|
0.75
|
64
|
Synthesis of dibenzothiophene-containing ladder polysilsesquioxane as a blue phosphorescent host material.
|
Chemistry
|
2012
|
0.75
|
65
|
Hyperthermal O-atom exchange reaction O2 + CO2 through a CO4 intermediate.
|
J Am Chem Soc
|
2009
|
0.75
|
66
|
Solvent-induced crystallization behaviors of PLLA ultrathin films investigated by RAIR spectroscopy and AFM measurements.
|
J Phys Chem B
|
2014
|
0.75
|
67
|
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency.
|
Cell Stem Cell
|
2014
|
0.75
|
68
|
Molecular weight dependence of the poly(L-lactide)/poly(D-lactide) Stereocomplex at the air-water interface.
|
Biomacromolecules
|
2006
|
0.75
|
69
|
TiO2 micro-devices fabricated by laser direct writing.
|
Opt Express
|
2011
|
0.75
|
70
|
A strategy to prepare wafer scale bismuth compound superstructures.
|
Small
|
2013
|
0.75
|
71
|
O(3P) + CO2 collisions at hyperthermal energies: dynamics of nonreactive scattering, oxygen isotope exchange, and oxygen-atom abstraction.
|
J Phys Chem A
|
2011
|
0.75
|
72
|
Study on the phase transition behavior of poly(butylene adipate) in its blends with poly(vinyl phenol).
|
J Phys Chem B
|
2011
|
0.75
|
73
|
Influence of underlay thickness on the period of nanoscale wrinkle.
|
J Nanosci Nanotechnol
|
2010
|
0.75
|
74
|
Acetylcholinesterase biosensor based on gold nanoparticles and cysteamine self assembled monolayer for determination of monocrotophos.
|
J Nanosci Nanotechnol
|
2009
|
0.75
|
75
|
Physical aging enhanced mesomorphic structure in melt-quenched poly(L-lactic acid).
|
J Phys Chem B
|
2011
|
0.75
|
76
|
Operable persistent photoconductivity of Bi2S3 nested nano-networks.
|
Phys Chem Chem Phys
|
2014
|
0.75
|
77
|
Exploring time-dependent structural changes during the cold crystallization process of isotactic polystyrene by infrared spectroscopy and multivariate curve resolution.
|
Appl Spectrosc
|
2006
|
0.75
|
78
|
Kinematics and dynamics of atomic-beam scattering on liquid and self-assembled monolayer surfaces.
|
Faraday Discuss
|
2012
|
0.75
|
79
|
Ionic Liquids Grafted Cellulose Nanocrystals for High Strength and Toughness PVA Nanocomposite.
|
ACS Appl Mater Interfaces
|
2020
|
0.75
|
80
|
Protecting polymers in space with atomic layer deposition coatings.
|
ACS Appl Mater Interfaces
|
2010
|
0.75
|
81
|
Hyperthermal Ar atom scattering from a C(0001) surface.
|
J Chem Phys
|
2008
|
0.75
|
82
|
Beam focusing by tapered metallic nano-slits.
|
J Nanosci Nanotechnol
|
2013
|
0.75
|
83
|
Theoretical and experimental studies of the reactions between hyperthermal O(3P) and graphite: graphene-based direct dynamics and beam-surface scattering approaches.
|
J Phys Chem A
|
2009
|
0.75
|
84
|
Lamellar orientation and crystallization dynamics of poly (L-lactic acid) thin films investigated by in-situ reflection absorption infrared spectroscopy.
|
J Phys Chem B
|
2011
|
0.75
|
85
|
Microarray analysis of liver gene expression before and after induced hemorrhagic shock in a rat model.
|
J Surg Res
|
2013
|
0.75
|
86
|
[Status of job burnout and its influential factors in seafarers].
|
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
|
2014
|
0.75
|
87
|
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency.
|
Cell Stem Cell
|
2014
|
0.75
|
88
|
Photoluminescence of silicon quantum dots in nanospheres.
|
Nanoscale
|
2012
|
0.75
|
89
|
Effects of argon dilution on the translational and rotational temperatures of SiH in silane and disilane plasmas.
|
J Phys Chem A
|
2005
|
0.75
|
90
|
Dynamics of hyperthermal collisions of O(3P) with CO.
|
J Phys Chem A
|
2008
|
0.75
|
91
|
MTMO grayscale photomask.
|
Opt Express
|
2010
|
0.75
|
92
|
Topotactic transformations of superstructures: from thin films to two-dimensional networks to nested two-dimensional networks.
|
J Am Chem Soc
|
2011
|
0.75
|
93
|
Study on π-π Interaction in H- and J-Aggregates of Poly(3-hexylthiophene) Nanowires by Multiple Techniques.
|
J Phys Chem B
|
2015
|
0.75
|
94
|
Charge and pressure-tuned surface patterning of surfactant-encapsulated polyoxometalate complexes at the air-water interface.
|
Langmuir
|
2012
|
0.75
|
95
|
A general strategy to superstructured networks and nested self-similar networks of bismuth compounds.
|
ACS Nano
|
2012
|
0.75
|