Published in Trends Cardiovasc Med on June 05, 2013
New insights into the role of soluble guanylate cyclase in blood pressure regulation. Curr Opin Nephrol Hypertens (2014) 0.77
Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2011) 31.98
Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation (2011) 14.00
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Nitrosylation. the prototypic redox-based signaling mechanism. Cell (2001) 5.38
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81
Gender differences in the regulation of blood pressure. Hypertension (2001) 3.78
Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature (1995) 3.23
Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J (1998) 2.96
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov (2006) 2.84
Genetic analysis of inherited hypertension in the rat. Physiol Rev (2000) 2.78
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest (2006) 2.52
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation (2005) 2.35
Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A (2007) 2.24
Genetic variation in laboratory mice. Nat Genet (2005) 2.12
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest (2006) 1.92
Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure. Hypertension (2007) 1.84
Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system. Hypertension (2000) 1.82
New target regions for human hypertension via comparative genomics. Genome Res (2000) 1.75
Structure and regulation of soluble guanylate cyclase. Annu Rev Biochem (2012) 1.72
Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest (2006) 1.69
Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme. J Hypertens (2002) 1.54
Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation (2004) 1.53
Genetic basis of blood pressure and hypertension. Trends Genet (2012) 1.51
High blood pressure arising from a defect in vascular function. Proc Natl Acad Sci U S A (2008) 1.50
Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44
Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. J Biol Chem (2001) 1.44
Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats. Hypertension (1992) 1.43
Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice. Cardiovasc Res (2008) 1.39
Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brain. Cell Signal (2003) 1.35
Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest (1997) 1.28
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc Res (2007) 1.23
sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol (2009) 1.21
Downregulation of angiotensin II type 1 receptor gene transcription by nitric oxide. Hypertension (1998) 1.12
Evolution and variation of renin genes in mice. Genetics (1984) 1.09
Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. J Mol Cell Cardiol (2004) 1.07
Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. J Am Soc Nephrol (2002) 1.01
Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia. Circulation (2007) 0.99
Cardiovascular and renal phenotype in mice with one or two renin genes. Hypertension (2003) 0.98
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo. Hypertension (2004) 0.97
Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice. Circulation (2010) 0.94
Gender differences in cardiac ACE expression are normalized in androgen-deprived male mice. Am J Physiol Heart Circ Physiol (2002) 0.92
cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3. Am J Physiol Renal Physiol (2006) 0.92
Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice. J Clin Invest (2012) 0.88
Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling. Curr Hypertens Rep (2013) 0.86
Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. J Biol Chem (2008) 0.85
Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo. Br J Pharmacol (2006) 0.85
Role of sex, gonadectomy and sex hormones in the development of nitric oxide inhibition-induced hypertension. Exp Physiol (2004) 0.82
The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning. Basic Res Cardiol (2011) 0.82
Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates. Biochem Pharmacol (2010) 0.82
Inhibition of intrarenal NO stimulates renin secretion through a macula densa-mediated mechanism. Am J Physiol (1997) 0.81
Mechanisms involved in the blunted nitric oxide-cGMP pathway in hypertensive TGR(mREN2)27 rats. Eur J Pharmacol (2001) 0.80
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res (2006) 2.02
Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury. Eur Heart J (2006) 1.98
Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice. Crit Care Med (2009) 1.63
Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol (2008) 1.35
Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation (2007) 1.35
MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol (2006) 1.30
A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol (2008) 1.18
Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest (2013) 1.17
Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis. Shock (2010) 1.05
Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice. Circulation (2011) 0.99
Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner. J Exp Med (2009) 0.98
Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med (2007) 0.96
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms. Anesthesiology (2011) 0.94
In vivo noninvasive characterization of brown adipose tissue blood flow by contrast ultrasound in mice. Circ Cardiovasc Imaging (2012) 0.91
Soluble guanylate cyclase-α1 is required for the cardioprotective effects of inhaled nitric oxide. Am J Physiol Heart Circ Physiol (2011) 0.88
sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling. Am J Physiol Heart Circ Physiol (2011) 0.88
Brown adipose tissue blood flow and mass in obesity: a contrast ultrasound study in mice. J Am Soc Echocardiogr (2013) 0.87
SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis. Am J Physiol Heart Circ Physiol (2013) 0.87
Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling. Curr Hypertens Rep (2013) 0.86
Soluble guanylate cyclase modulates alveolarization in the newborn lung. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury. Stroke (2010) 0.84
Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide (2011) 0.80
Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice). Naunyn Schmiedebergs Arch Pharmacol (2008) 0.78
Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci (2013) 0.78
Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2007) 0.77
Assessing murine resistance artery function using pressure myography. J Vis Exp (2013) 0.76
Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice. Shock (2016) 0.75