Published in J Control Release on June 22, 2013
Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies. FASEB J (2015) 0.87
Engineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload delivery. Immunol Rev (2016) 0.78
TriFabs-Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery. Int J Mol Sci (2015) 0.77
A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties. PLoS One (2015) 0.75
PK modulation of peptides by hapten-mediated antibody complexation. J Control Release (2013) 0.75
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med (2003) 3.37
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. Gastroenterology (2003) 2.97
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol Cell (2009) 2.00
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med (2013) 1.72
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene. Clin Pharmacol Ther (2002) 1.58
Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway. Proc Natl Acad Sci U S A (2006) 1.37
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics (2002) 1.34
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies. MAbs (2012) 1.29
MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine. Br J Clin Pharmacol (2002) 1.28
Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis. Proc Natl Acad Sci U S A (2008) 1.22
Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. J Am Soc Nephrol (2002) 1.21
Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes (2013) 1.20
Bispecific digoxigenin-binding antibodies for targeted payload delivery. Proc Natl Acad Sci U S A (2011) 1.15
Digoxin pharmacokinetics and MDR1 genetic polymorphisms. Eur J Clin Pharmacol (2003) 1.14
A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors. PLoS One (2013) 1.07
Development of secreted proteins as biotherapeutic agents. Expert Opin Biol Ther (2004) 1.06
Prospects of bacterial and plant protein-based immunotoxins for treatment of cancer. Cancer Genomics Proteomics (2014) 1.04
A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II C-terminal repeat domain (CTD). J Biol Chem (2010) 1.00
Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies. MAbs (2013) 0.98
Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition. Arch Biochem Biophys (2012) 0.97
Quality requirements for critical assay reagents used in bioanalysis of therapeutic proteins: what bioanalysts should know about their reagents. Bioanalysis (2011) 0.95
Advanced glycation end products and receptor for advanced glycation end products in AA amyloidosis. Am J Pathol (2003) 0.92
Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition. Clin Pharmacol Ther (2003) 0.90
Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains. Antimicrob Agents Chemother (2011) 0.90
Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. Am J Pathol (2003) 0.90
High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide. Mol Cell Proteomics (2004) 0.89
Clinical chemistry of human FcRn transgenic mice. Mamm Genome (2011) 0.88
Self-adjuvanting glycopeptide conjugate vaccine against disseminated candidiasis. PLoS One (2012) 0.86
Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes. Endocrinology (2009) 0.86
The emerging role of new protein scaffold-based agents for treatment of cancer. Cancer Genomics Proteomics (2013) 0.85
The intriguing options of multispecific antibody formats for treatment of cancer. Cancer Genomics Proteomics (2013) 0.85
Fluorescent Citrine-IgG fusion proteins produced in mammalian cells. MAbs (2010) 0.84
Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing. Protein Eng Des Sel (2012) 0.83
Endostatin down-regulates soluble guanylate cyclase (sGC) in endothelial cells in vivo: influence of endostatin on vascular endothelial growth factor (VEGF) signaling. Endothelium (2006) 0.82
High throughput functional genomics: identification of novel genes with tumor suppressor phenotypes. Int J Cancer (2005) 0.82
Influence of TBK-1 on tumor angiogenesis and microvascular inflammation. Front Biosci (2008) 0.81
Allosteric antibody inhibition of human hepsin protease. Biochem J (2012) 0.81
A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies. MAbs (2014) 0.81
Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity. Bioorg Med Chem Lett (2007) 0.81
Multimetallic ruthenium(II) complexes as electrochemiluminescent labels. Inorg Chem (2003) 0.81
Fatty acids increase presenilin-1 levels and [gamma]-secretase activity in PSwt-1 cells. J Lipid Res (2004) 0.81
Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction. Microvasc Res (2006) 0.81
Sex and hormonal status influence the effects of psyllium on lipoprotein remodeling and composition. Metabolism (2002) 0.81
Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives. Bioorg Med Chem Lett (2006) 0.81
The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children. Atherosclerosis (2004) 0.80
Preparation and characterization of albumin conjugates of a truncated peptide YY analogue for half-life extension. Bioconjug Chem (2013) 0.80
Bispecific antibody derivatives based on full-length IgG formats. Methods Mol Biol (2012) 0.80
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes. Pharmacogenet Genomics (2007) 0.79
The translational potential for target validation and therapy using intracellular antibodies in oncology. Cancer Genomics Proteomics (2013) 0.79
Fully human targeted cytotoxic fusion proteins: new anticancer agents on the horizon. Cancer Genomics Proteomics (2012) 0.79
Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19. Pharmacogenetics (2003) 0.78
Human-protein-derived peptides for intracellular delivery of biomolecules. Biochem J (2012) 0.78
Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators. Bioorg Med Chem Lett (2013) 0.78
Competitive homogeneous digoxigenin immunoassay based on fluorescence quenching by gold nanoparticles. Anal Chim Acta (2009) 0.77
Influence of GSTT1 and GSTM1 genotypes on sunburn sensitivity. Am J Pharmacogenomics (2002) 0.77
Genetically engineered fusion proteins for treatment of cancer. Cancer Genomics Proteomics (2012) 0.77
Bioconjugated fluorescent zeolite L nanocrystals as labels in protein microarrays. Small (2011) 0.77
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells. World J Gastroenterol (2008) 0.76
Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease. J Cancer Res Clin Oncol (2009) 0.76
Synthetic glycopeptides from the mucin family as potential tools in cancer immunotherapy. Curr Cancer Drug Targets (2006) 0.76
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett (2011) 0.76
Common denominator procedure: a novel approach to gene-expression data mining for identification of phenotype-specific genes. Bioinformatics (2005) 0.76
The (2-phenyl-2-trimethylsilyl)ethyl-(PTMSEL)-linker in the synthesis of glycopeptide partial structures of complex cell surface glycoproteins. Chemistry (2003) 0.75
Generation of fluorescent IgG fusion proteins in mammalian cells. Methods Mol Biol (2012) 0.75
Effect of the new matrix metalloproteinase inhibitor RO-28-2653 on mitochondrial function. Biochem Pharmacol (2002) 0.75
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists. Bioorg Med Chem Lett (2013) 0.75
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors. Bioorg Med Chem Lett (2011) 0.75
Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women. J Nutr Biochem (2004) 0.75
Potent, selective MCH-1 receptor antagonists. Bioorg Med Chem Lett (2008) 0.75
Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs. Bioorg Med Chem Lett (2013) 0.75
Identification of twelve polymorphisms in the endothelin-1 gene by use of fluorescently labeled oligonucleotides and PCR with restriction fragment polymorphism analysis. Clin Chem (2004) 0.75