| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.
|
Mol Cancer Ther
|
2009
|
1.31
|
|
2
|
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
|
Cancer Prev Res (Phila)
|
2012
|
1.11
|
|
3
|
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
|
Mol Cancer Ther
|
2013
|
1.10
|
|
4
|
Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.
|
J Med Chem
|
2010
|
0.89
|
|
5
|
Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.
|
Arch Pharm (Weinheim)
|
2010
|
0.82
|
|
6
|
A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.
|
Med Chem
|
2010
|
0.81
|
|
7
|
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.
|
Eur J Med Chem
|
2012
|
0.80
|
|
8
|
Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents.
|
Med Chem
|
2012
|
0.79
|
|
9
|
Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.
|
J Med Chem
|
2014
|
0.78
|
|
10
|
Discovery of highly potent and selective D4 ligands by interactive SAR study.
|
Bioorg Med Chem Lett
|
2013
|
0.78
|
|
11
|
6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.
|
ChemMedChem
|
2013
|
0.78
|
|
12
|
One-pot synthesis of 4,6-diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38alpha MAP kinase inhibition.
|
J Comb Chem
|
2010
|
0.77
|
|
13
|
Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.
|
Arch Pharm (Weinheim)
|
2013
|
0.76
|
|
14
|
Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands.
|
Bioorg Med Chem
|
2010
|
0.76
|
|
15
|
CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents.
|
Med Chem
|
2012
|
0.75
|
|
16
|
An interactive SAR approach to discover novel hybrid thieno probes as ligands for D2-like receptors with affinities in the subnanomolar range.
|
Chem Biodivers
|
2013
|
0.75
|
|
17
|
Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes.
|
J Enzyme Inhib Med Chem
|
2012
|
0.75
|
|
18
|
Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.
|
Eur J Med Chem
|
2013
|
0.75
|
|
19
|
Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand.
|
Bioorg Med Chem
|
2007
|
0.75
|
|
20
|
Discovery of a novel series of tetrahydro-β-carbolines inducing autophagic cell death in human metastatic melanoma.
|
Arch Pharm (Weinheim)
|
2014
|
0.75
|
|
21
|
Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.
|
Bioorg Med Chem
|
2013
|
0.75
|
|
22
|
Synthesis and antitubercular activity of 6-chloro (unsubstituted)- 2-methoxy-9-substituted acridine derivatives.
|
Arch Pharm Res
|
2004
|
0.75
|