Published in J Virol on July 10, 2013
Ethical alternatives to experiments with novel potential pandemic pathogens. PLoS Med (2014) 1.68
Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016) 1.56
Full-genome analysis of avian influenza A(H5N1) virus from a human, North America, 2013. Emerg Infect Dis (2014) 1.27
Improving pandemic influenza risk assessment. Elife (2014) 1.20
The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication. Nat Commun (2014) 1.13
Viral factors in influenza pandemic risk assessment. Elife (2016) 0.94
PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses. Sci Rep (2016) 0.86
Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation. Sci Rep (2015) 0.81
Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations. Nucleic Acids Res (2015) 0.79
Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds. PLoS One (2016) 0.77
The RNA-dependent RNA polymerase of the influenza A virus. Future Virol (2014) 0.76
Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures. Sci Rep (2016) 0.75
Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice. PLoS One (2015) 0.75
An in vivo system for directed experimental evolution of rabbit haemorrhagic disease virus. PLoS One (2017) 0.75
Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined. Sci Rep (2017) 0.75
The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents. Clin Exp Vaccine Res (2017) 0.75
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science (1998) 19.40
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (2001) 18.43
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature (2004) 16.76
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet (1998) 16.30
Characterization of the 1918 influenza virus polymerase genes. Nature (2005) 15.73
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature (2012) 14.17
Airborne transmission of influenza A/H5N1 virus between ferrets. Science (2012) 13.48
The influenza virus resource at the National Center for Biotechnology Information. J Virol (2007) 11.33
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol (1993) 10.22
Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature (2005) 10.04
Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64
Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A (2006) 9.26
Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog (2009) 6.09
PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology (2004) 5.96
Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol (2005) 5.40
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J Virol (2006) 5.26
Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J Virol (1999) 5.21
Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology (1999) 5.07
Pathogenesis of avian influenza A (H5N1) viruses in ferrets. J Virol (2002) 4.87
Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog (2007) 4.49
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill (2013) 4.44
An overview of the epidemiology of avian influenza. Vaccine (2006) 4.10
Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci U S A (2009) 3.89
Molecular correlates of influenza A H5N1 virus pathogenesis in mice. J Virol (2000) 3.74
Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand. J Gen Virol (2005) 3.63
The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host. Science (2012) 3.50
Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J Virol (2001) 3.43
Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus. J Virol (1994) 3.31
The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses. Virology (1979) 3.25
Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. J Mol Biol (2008) 3.00
A statistical phylogeography of influenza A H5N1. Proc Natl Acad Sci U S A (2007) 2.91
Molecular and antigenic evolution and geographical spread of H5N1 highly pathogenic avian influenza viruses in western Africa. J Gen Virol (2007) 2.41
Genome packaging in influenza A virus. J Gen Virol (2009) 2.40
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol (2010) 2.35
Host restriction of avian influenza viruses at the level of the ribonucleoproteins. Annu Rev Microbiol (2008) 2.29
Codon conservation in the influenza A virus genome defines RNA packaging signals. Nucleic Acids Res (2007) 2.24
Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol (2007) 2.20
History of highly pathogenic avian influenza. Rev Sci Tech (2009) 2.00
Genetic characterization of H5N1 influenza A viruses isolated from zoo tigers in Thailand. Virology (2005) 1.79
A supramolecular assembly formed by influenza A virus genomic RNA segments. Nucleic Acids Res (2011) 1.65
Pathogenesis of highly pathogenic avian influenza A/turkey/Turkey/1/2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally. Avian Pathol (2008) 1.48
Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. J Virol (2010) 1.46
Characterization of a highly pathogenic H5N1 influenza virus derived from bar-headed geese in China. J Gen Virol (2006) 1.46
Sequences in influenza A virus PB2 protein that determine productive infection for an avian influenza virus in mouse and human cell lines. J Virol (2001) 1.42
Adaptation of an H7N7 equine influenza A virus in mice. J Gen Virol (2007) 1.41
Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. Nat Commun (2012) 1.41
Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis. Euro Surveill (2013) 1.38
Differences in influenza virus receptors in chickens and ducks: Implications for interspecies transmission. J Mol Genet Med (2009) 1.38
Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China. J Virol (2009) 1.27
A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level. PLoS One (2012) 1.21
Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Virology (2010) 1.13
Characterization of influenza virus sialic acid receptors in minor poultry species. Virol J (2010) 1.13
Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses. J Virol (2011) 1.13
The influenza A virus PB2, PA, NP, and M segments play a pivotal role during genome packaging. J Virol (2012) 1.12
An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus. Nucleic Acids Res (2012) 1.10
Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193. Arch Virol (2004) 1.05
Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J Virol (2011) 1.03
Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein. J Virol (2009) 1.01
Interaction network linking the human H3N2 influenza A virus genomic RNA segments. Vaccine (2012) 0.98
Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo. J Virol (2011) 0.97
Replication of influenza A viruses of high and low pathogenicity for chickens at different sites in chickens and ducks following intranasal inoculation. Avian Pathol (1995) 0.96
Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice. PLoS One (2012) 0.95
Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/England/50-92/91 (H5N1). Avian Dis (2007) 0.95
The effect of age on the pathogenesis of a highly pathogenic avian influenza (HPAI) H5N1 virus in Pekin ducks (Anas platyrhynchos) infected experimentally. Influenza Other Respir Viruses (2010) 0.94
Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variants. J Gen Virol (2010) 0.91
Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks. Arch Virol (2011) 0.91
Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks. PLoS One (2012) 0.89
Investigation of influenza virus polymerase activity in pig cells. J Virol (2012) 0.88
Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models. Virology (2010) 0.88
An outbreak of highly pathogenic avian influenza in turkeys in Great Britain in 1991. Vet Rec (1993) 0.87
Infection of human airway epithelium by human and avian strains of influenza a virus. J Virol (2006) 3.02
Recombination resulting in virulence shift in avian influenza outbreak, Chile. Emerg Infect Dis (2004) 2.94
A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J Virol (2009) 2.94
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature (2013) 2.79
Pause on avian flu transmission research. Science (2012) 2.24
Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs. PLoS One (2010) 2.04
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Suppression of avian influenza transmission in genetically modified chickens. Science (2011) 1.85
A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria. J Gen Virol (2004) 1.57
Structure of an avian influenza A virus NS1 protein effector domain. Virology (2008) 1.50
Pathogenesis of highly pathogenic avian influenza A/turkey/Turkey/1/2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally. Avian Pathol (2008) 1.48
Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. J Virol (2010) 1.46
Automated analysis of phylogenetic clusters. BMC Bioinformatics (2013) 1.38
Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host. J Virol (2004) 1.37
Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. PLoS One (2009) 1.33
Receptor-binding profiles of H7 subtype influenza viruses in different host species. J Virol (2012) 1.29
Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. PLoS Pathog (2009) 1.27
Highly pathogenic avian influenza viruses with low virulence for chickens in in vivo tests. Avian Pathol (2007) 1.22
Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J (2003) 1.21
Validated RealTime reverse transcriptase PCR methods for the diagnosis and pathotyping of Eurasian H7 avian influenza viruses. Influenza Other Respir Viruses (2009) 1.18
Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation. Nucleic Acids Res (2007) 1.16
Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host. J Antimicrob Chemother (2004) 1.15
Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells. J Virol (2012) 1.14
Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells. J Virol (2007) 1.14
RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations. J Neurochem (2009) 1.12
A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA. J Virol (2002) 1.12
Generation of candidate human influenza vaccine strains in cell culture - rehearsing the European response to an H7N1 pandemic threat. Influenza Other Respir Viruses (2007) 1.12
A review of RT-PCR technologies used in veterinary virology and disease control: sensitive and specific diagnosis of five livestock diseases notifiable to the World Organisation for Animal Health. Vet Microbiol (2009) 1.10
Molecular studies of influenza B virus in the reverse genetics era. J Gen Virol (2010) 1.09
Transmission studies resume for avian flu. Science (2013) 1.07
A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets. PLoS One (2011) 1.07
Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo. J Gen Virol (2011) 1.07
Nucleic acid sequence-based amplification methods to detect avian influenza virus. Biochem Biophys Res Commun (2004) 1.06
Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility. J Gen Virol (2013) 1.05
Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness. J Antimicrob Chemother (2010) 1.03
Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase. J Gen Virol (2011) 1.03
Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development. Mol Cell Biol (2002) 1.03
Fatal cases of influenza a in childhood. PLoS One (2009) 0.98
Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential. J Virol (2010) 0.97
Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures. Nat Protoc (2006) 0.97
Genetic Characterization of Highly Pathogenic Avian Influenza (H5N8) Virus from Domestic Ducks, England, November 2014. Emerg Infect Dis (2015) 0.97
The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets. J Virol (2013) 0.96
Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/England/50-92/91 (H5N1). Avian Dis (2007) 0.95
Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC. Eur J Immunol (2010) 0.95
Pandemic risks from bird flu. BMJ (2004) 0.95
Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model. PLoS One (2012) 0.94
Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults. Eur J Immunol (2012) 0.94
Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation. Nucleic Acids Res (2011) 0.94
The effect of age on the pathogenesis of a highly pathogenic avian influenza (HPAI) H5N1 virus in Pekin ducks (Anas platyrhynchos) infected experimentally. Influenza Other Respir Viruses (2010) 0.94
Experimental infection of turkeys with pandemic (H1N1) 2009 influenza virus (A/H1N1/09v). J Virol (2009) 0.90
Obesity and susceptibility to severe outcomes following respiratory viral infection. Thorax (2013) 0.88
Investigation of influenza virus polymerase activity in pig cells. J Virol (2012) 0.88
Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes. PLoS One (2012) 0.88
Report of the 5th meeting on the evaluation of pandemic influenza prototype vaccines in clinical trials: World Health Organization, Geneva, Switzerland, 12-13 February 2009. Vaccine (2009) 0.86
Rapid PCR-based molecular pathotyping of H5 and H7 avian influenza viruses. J Clin Microbiol (2011) 0.85
Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. J Virol (2010) 0.85
Atypical non-progressive pneumonia in goats. Vet J (2009) 0.83
Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle. Genome Biol (2009) 0.83
Characterisation of a highly pathogenic influenza A virus of subtype H5N2 isolated from ostriches in South Africa in 2004. Influenza Other Respir Viruses (2009) 0.83
Histopathological and ultrastructural changes associated with herpesvirus infection in waterfowl. Avian Pathol (2002) 0.83
A RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell death. PLoS One (2008) 0.82
The infectivity of pandemic 2009 H1N1 and avian influenza viruses for pigs: an assessment by ex vivo respiratory tract organ culture. Influenza Other Respir Viruses (2012) 0.82
Interspecies protein substitution to investigate the role of the lyssavirus glycoprotein. J Gen Virol (2012) 0.82
Challenges for accurate and prompt molecular diagnosis of clades of highly pathogenic avian influenza H5N1 viruses emerging in Vietnam. Avian Pathol (2012) 0.82
A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers. Mol Cell Proteomics (2007) 0.81
First reported detection of influenza A (H1N1)pdm09 in turkeys in the United Kingdom. Avian Dis (2012) 0.79
Serum concentrations of C-reactive protein, serum amyloid A, and haptoglobin in pigs inoculated with African swine fever or classical swine fever viruses. Am J Vet Res (2007) 0.79
Overview of incursions of Asian H5N1 subtype highly pathogenic avian influenza virus into Great Britain, 2005-2008. Avian Dis (2010) 0.79
Evaluation of lateral flow devices for identification of infected poultry by testing swab and feather specimens during H5N1 highly pathogenic avian influenza outbreaks in Vietnam. Influenza Other Respir Viruses (2011) 0.78
One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential. Bioessays (2014) 0.78
Diagnosis, management and post-mortem findings of a human case of rabies imported into the United Kingdom from India: a case report. Virol J (2014) 0.77
Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation. World J Urol (2009) 0.77
Enhanced infectivity of H5N1 highly pathogenic avian influenza (HPAI) virus in pig ex vivo respiratory tract organ cultures following adaptation by in vitro passage. Virus Res (2013) 0.76
Evaluation of two commercial lateral flow devices (LFDs) used for flockside testing of H5N1 highly-pathogenic avian influenza infections in backyard gallinaceous poultry in Egypt. J Mol Genet Med (2010) 0.75
[Anuran fauna from Salta city, Argentina]. Rev Biol Trop (2007) 0.75