Published in Annu Rev Pharmacol on January 01, 1975
Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A (1979) 2.66
Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey. Br J Pharmacol (1975) 2.05
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. Proc Natl Acad Sci U S A (1981) 1.74
The mechanism of action of narcotic analgesics in the guinea-pig ileum. Br J Pharmacol (1977) 1.63
A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci U S A (1993) 1.46
Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc Natl Acad Sci U S A (1985) 1.44
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists). Proc Natl Acad Sci U S A (1980) 1.26
Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones. Br J Pharmacol (1983) 1.16
Action of morphine on the neuro-effector transmission in the guinea-pig ileum and in the mouse vas deferens. J Physiol (1980) 1.07
Opioid inhibition of synaptic transmission in the guinea-pig myenteric plexus. Br J Pharmacol (1985) 1.04
Effects of opioids on noncholinergic excitatory responses of the guinea-pig isolated ileum: inhibition of release of enteric substance P. Br J Pharmacol (1982) 1.01
Comparison of the receptor binding characteristics of opiate agonists interacting with mu- or kappa-receptors. Br J Pharmacol (1978) 0.98
Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions. Br J Pharmacol (1988) 0.93
Proposal for the biologically active conformation of opiates and enkephalin. Proc Natl Acad Sci U S A (1977) 0.90
Pharmacological characterization of opiate physical dependence in the isolated ileum of the guinea-pig. Br J Pharmacol (1981) 0.88
Opiate-like analgesic activity in general anaesthetics. Br J Pharmacol (1981) 0.88
Inhibition of neuronal firing by opiates: evidence against the involvement of cyclic nucleotides. Br J Pharmacol (1979) 0.85
Structural requirements in the reaction of morphine uridine diphosphate glucuronyltransferase with opioid substances. Biochem J (1978) 0.84
Effects of endorphins on different parts of the gastrointestinal tract of rat and guinea-pig in vitro. Br J Pharmacol (1980) 0.84
Manifestations of acute opiate withdrawal contracture in rabbit jejunum after mu-, kappa- and delta-receptor agonist exposure. Br J Pharmacol (1992) 0.83
Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists. Br J Pharmacol (1988) 0.83
Kinetics of morphine-sensitive [3H]-acetylcholine release from the guinea-pig myenteric plexus. Br J Pharmacol (1980) 0.82
Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release. Br J Pharmacol (1988) 0.81
Inhibition of [3H]-naloxone binding by opiate agonists [proceedings]. Br J Pharmacol (1977) 0.80
Contractile effect of morphine and related opioid alkaloids, beta-endorphin and methionine enkephalin on the isolated colon from Long Evans rats. Br J Pharmacol (1981) 0.79
Dextrorphan binds to opioid receptors in guinea-pig brain membranes and is an antagonist at opioid receptors in myenteric plexus. Proc Natl Acad Sci U S A (1990) 0.79
Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation. Anesthesiology (2013) 0.77
Enkephalins in large bowel malignancy and in acute appendicitis. Gut (1979) 0.75
A study of the role of cyclic adenosine 3',5'-monophosphate in the depression by opiates and opioid peptides of excitatory junction potentials in the mouse vas deferens. Br J Pharmacol (1980) 0.75
In Vitro and In Vivo Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential. Front Psychiatry (2017) 0.75
Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature (1975) 10.33
Endogenous opioid peptides: multiple agonists and receptors. Nature (1977) 8.21
Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone). Br J Pharmacol Chemother (1968) 5.00
The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum. Br J Pharmacol (1970) 4.22
A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens. Br J Pharmacol (1972) 4.11
Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics. Br J Pharmacol (1975) 3.76
The effects of changes in dietary protein on the composition and structure of the liver cell. J Physiol (1947) 3.07
Mode of action of morphine-like drugs on autonomic neuro-effectors. Nature (1968) 3.01
Agonist and antagonist actions of morphine-like drugs on the guinea-pig isolated ileum. Br J Pharmacol Chemother (1966) 2.67
The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. Br J Pharmacol (1977) 2.59
The effects of hexamethonium, morphine and adrenaline on the output of acetylcholine from the myenteric plexus-longitudinal muscle preparation of the ileum. Br J Pharmacol (1970) 2.43
Classification of opioid receptors. Br Med Bull (1983) 2.12
Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey. Br J Pharmacol (1975) 2.05
The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn Schmiedebergs Arch Pharmacol (1982) 1.99
Spectrum of the mu, delta- and kappa-binding sites in homogenates of rat brain. Br J Pharmacol (1982) 1.91
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain. Br J Pharmacol (1981) 1.80
Incorporation of labelled amino acids into the enkephalins. FEBS Lett (1977) 1.73
Some thoughts on the significance of enkephalin, the endogenous ligand. Life Sci (1975) 1.71
Resting and action potentials recorded by the sucrose-gap method in the superior cervical ganglion of the rabbit. J Physiol (1968) 1.61
Comparison of the binding characteristics of tritiated opiates and opioid peptides. Br J Pharmacol (1980) 1.56
In vitro pharmacology of the opioid peptides, enkephalins and endorphins. Eur J Pharmacol (1977) 1.56
Characterization of opioid receptors in nervous tissue. Proc R Soc Lond B Biol Sci (1980) 1.52
Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor. Br J Pharmacol (1984) 1.47
Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with mu- and delta-receptors. Br J Pharmacol (1980) 1.47
The utilization of fat by the aglycaemic mammalian heart. J Physiol (1941) 1.46
Dynorphin and dynorphin are ligands for the kappa-subtype of opiate receptor. Nature (1982) 1.35
Increase in potencies of opioid peptides after peptidase inhibition. Eur J Pharmacol (1983) 1.31
The Wellcome Foundation lecture, 1982. Opioid peptides and their receptors. Proc R Soc Lond B Biol Sci (1985) 1.23
Stereospecific increase by narcotic antagonists of evoked acetylcholine output in guinea-pig ileum. Life Sci (1975) 1.20
Intrinsic intestinal reflexes. Am J Dig Dis (1967) 1.17
Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors). Proc R Soc Lond B Biol Sci (1979) 1.16
Spontaneous electrical activity and nerve-mediated inhibition in the innervated longitudinal muscle strip of the guinea-pig ileum. J Physiol (1969) 1.15
Factors influencing the release of acetylcholine from the myenteric plexus of the ileum of the guinea-pig and rabbit. Br J Pharmacol (1978) 1.15
Proceedings: Assessment of the agonist and antagonist activities of narcotic analgesic drugs by means of the mouse vas deferens. Br J Pharmacol (1974) 1.10
Opioid activities of fragments of beta-endorphin and of its leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin. Eur J Pharmacol (1979) 1.08
The effects of hexamethonium and morphine on transmission in the superior cervical ganglion of the rabbit. Br J Pharmacol Chemother (1966) 1.08
Opioid binding sites of the kappa-type in guinea-pig cerebellum. Neuroscience (1984) 1.06
The assay of the nutritive value of a protein by its effect on liver cytoplasm. J Physiol (1948) 1.04
Control by cations of opioid binding in guinea pig brain membranes. Proc Natl Acad Sci U S A (1986) 1.04
Unexpected antagonism in the rat vas deferens by benzomorphans which are agonists in other pharmacological tests. Br J Pharmacol (1981) 1.03
The opioid receptors in the hamster vas deferens are of the delta-type. Neuropharmacology (1985) 1.03
The use of [3H]-[D-Pen2,D-Pen5]enkephalin as a highly selective ligand for the delta-binding site. Br J Pharmacol (1985) 1.03
Differences in the inhibitory effects of normorphine and opioid peptides on the responses of the vasa deferentia of two strains of mice. Eur J Pharmacol (1978) 1.03
Assessment of the agonist and antagonist properties of narcotic analgesic drugs by their actions on the morphine receptor in the guinea pig ileum. Adv Biochem Psychopharmacol (1973) 1.01
Structure-activity relationships of methionine-enkephalin. J Pharm Pharmacol (1976) 1.01
Opioid peptides. Br Med Bull (1977) 1.01
Kappa-binding and degradation of [3H]dynorphin A (1-8) and [3H]dynorphin A (1-9) in suspensions of guinea pig brain membranes. J Neurochem (1985) 0.99
Bremazocine is an agonist at kappa-opioid receptors and an antagonist at mu-opioid receptors in the guinea-pig myenteric plexus. Br J Pharmacol (1986) 0.98
The effect of the interval between electrical stimuli on the acetylcholine output of the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum. Br J Pharmacol (1970) 0.98
Comparison of the receptor binding characteristics of opiate agonists interacting with mu- or kappa-receptors. Br J Pharmacol (1978) 0.98
The effects of morphine on the release of noradrenaline from the cat isolated nictitating membrane and the guinea-pig ileum myenteric plexus-longitudinal muscle preparation. Br J Pharmacol (1975) 0.98
Impulse transmission in the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum. Br J Pharmacol (1971) 0.97
Recording resting and action potentials by the sucrose-gap method. Comp Biochem Physiol C (1975) 0.96
Further evidence for an electrogenic sodium pump in a mammalian sympathetic ganglion. Br J Pharmacol (1970) 0.96
The digestibility of the phytic acid of oatmeal in adult man. J Physiol (1945) 0.95
Non-specific inhibitory effects of morphine-like drugs on transmission in the superior cervical ganglion and guinea-pig isolated ileum. Br J Pharmacol (1968) 0.94
In vitro release of Leu- and Met-enkephalin from the corpus striatum. Nature (1978) 0.94
Species differences in the concentrations and distributions of opioid binding sites. Eur J Pharmacol (1985) 0.94
Rates of onset and offset of action of narcotic analgesics in isolated preparations. Eur J Pharmacol (1975) 0.93
An analysis of the phenomenon of acute tolerance to morphine in the guinea-pig isolated ileum. Br J Pharmacol (1975) 0.90
Cross tolerance between morphine and methionine-enkephalin. Nature (1976) 0.89
Types of opioid receptors: relation to antinociception. Philos Trans R Soc Lond B Biol Sci (1985) 0.89
Characterization of opioid peptides in guinea-pig heart and skin. Life Sci (1983) 0.89
Some aspects of transmission at the nerve-smooth muscle junction in the longitudinal muscle of the guinea pig ileum. Am J Dig Dis (1968) 0.88
The relationship between losses in labile liver cytoplasm and urinary nitrogen excretion. Biochem J (1948) 0.88
Differential postnatal development of mu-, delta- and kappa-opioid binding sites in rat brain. Brain Res (1987) 0.88
The inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro. Br J Pharmacol (1979) 0.88
Hamster vas deferens contains delta-opioid receptors. Neuropeptides (1984) 0.87
Effects of physostigmine and electrical stimulation on the acetylcholine content of the guinea-pig ileum. Eur J Pharmacol (1976) 0.87
Radioligands for probing opioid receptors. J Recept Res (1984) 0.85
Non-adrenergic, non-cholinergic autonomic neurotransmission mechanisms. Neurosci Res Program Bull (1979) 0.85
Effects of cations on binding, in membrane suspensions, of various opioids at mu-sites of rabbit cerebellum and kappa-sites of guinea-pig cerebellum. Br J Pharmacol (1987) 0.85
Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A (1983) 0.85
Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum. Eur J Pharmacol (1987) 0.84
Differential effects of drugs on the acetylcholine output from the myenteric plexus and the responses of the longitudinal muscle of the guinea-pig ileum. Br J Pharmacol (1972) 0.84
Tritiated etorphine and naloxone binding to opioid receptors in caudate nucleus in schizophrenia. Br J Psychiatry (1985) 0.84
Differential postnatal development of mu-, delta-and chi-opioid binding sites in mouse brain. Brain Res (1985) 0.84
Opioid Peptides: introduction. Br Med Bull (1983) 0.84
Tetraethylammonium facilitates the stimulation-evoked loss of the enkephalins from the myenteric plexus of guinea-pig ileum. Proc R Soc Lond B Biol Sci (1981) 0.84
The effects of morphine-like substances and their antagonists on transmission at the neuro-effector junction of the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum. Br J Pharmacol (1970) 0.84
Effects of calcium and manganese on acetylcholine release from the myenteric plexus of guinea-pig and rabbit ileum. Br J Pharmacol (1972) 0.84