PubRank

Paul Beroza

Author PubWeight™ 11.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem 2005 1.33
2 Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol 2004 1.18
3 A novel shape-feature based approach to virtual library screening. J Chem Inf Comput Sci 2002 0.88
4 Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain. ChemMedChem 2013 0.87
5 Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors. Biochem Biophys Res Commun 2013 0.84
6 Shapes of things: computer modeling of molecular shape in drug discovery. Curr Top Med Chem 2007 0.84
7 Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem 2011 0.83
8 Including explicit water molecules as part of the protein structure in MM/PBSA calculations. J Chem Inf Model 2014 0.83
9 Improved ligand binding energies derived from molecular dynamics: replicate sampling enhances the search of conformational space. J Chem Inf Model 2013 0.80
10 Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints. J Med Chem 2004 0.80
11 Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. Bioorg Med Chem Lett 2013 0.77
12 Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bioorg Med Chem Lett 2013 0.76
13 Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors. Bioorg Med Chem Lett 2013 0.76
14 Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target. PLoS One 2013 0.76
15 Characterization of a membrane-active anti-tumor agent, UA8967. Invest New Drugs 2012 0.75