Exposure to environmental toxicants and pathogenesis of amyotrophic lateral sclerosis: state of the art and research perspectives.

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Published in Int J Mol Sci on July 24, 2013

Authors

Francesca Trojsi1, Maria Rosaria Monsurrò, Gioacchino Tedeschi

Author Affiliations

1: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Piazza Miraglia 2, Naples 80138, Italy. francesca.trojsi@unina2.it

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature (1993) 21.65

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The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder. Chem Res Toxicol (2001) 3.59

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Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology (2006) 2.38

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis. J Biol Chem (2002) 2.34

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Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam. Neurology (2003) 2.27

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Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science (1999) 2.17

Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol (2005) 1.97

Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution, with special reference to the Mariana Islands, including clinical and pathologic observations. Neurology (1954) 1.90

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Occupational exposures and amyotrophic lateral sclerosis. A population-based case-control study. Am J Epidemiol (1997) 1.73

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Endemic selenium intoxication of humans in China. Am J Clin Nutr (1983) 1.61

Pesticides. Pediatrics (2004) 1.60

Paraoxonase gene polymorphisms and sporadic ALS. Neurology (2006) 1.56

Spatial clustering of amyotrophic lateral sclerosis in Finland at place of birth and place of death. Am J Epidemiol (2003) 1.54

Motor neurone disease and exposure to lead. J Neurol Neurosurg Psychiatry (1970) 1.52

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Pathogenic superoxide dismutase structure, folding, aggregation and turnover. Curr Opin Chem Biol (2006) 1.44

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Neurotoxic flying foxes as dietary items for the Chamorro people, Marianas Islands. J Ethnopharmacol (2006) 1.38

Cyanobacterial Blooms and the Occurrence of the neurotoxin beta-N-methylamino-L-alanine (BMAA) in South Florida Aquatic Food Webs. Harmful Algae (2010) 1.36

Abnormal tissue distribution of lead in amyotrophic lateral sclerosis. J Neurol Sci (1976) 1.31

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure. Proc Natl Acad Sci U S A (2010) 1.30

Amyotrophic lateral sclerosis in a high selenium environment. JAMA (1977) 1.29

Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol Appl Pharmacol (1999) 1.28

Molecular neuropathology of TDP-43 proteinopathies. Int J Mol Sci (2009) 1.26

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Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury. Curr Mol Med (2004) 1.23

Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. Neurotoxicology (2012) 1.23

Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohorts. Arch Neurol (2011) 1.23

Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry (2010) 1.22

Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol Appl Pharmacol (2008) 1.21

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Production of the neurotoxin BMAA by a marine cyanobacterium. Mar Drugs (2007) 1.15

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Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells. BMC Neurosci (2007) 1.14

Amyotrophic lateral sclerosis. Curr Opin Neurol (2012) 1.13

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Amyotrophic lateral sclerosis as a complex genetic disease. Biochim Biophys Acta (2006) 1.13

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Mercury intoxication simulating amyotrophic lateral sclerosis. JAMA (1983) 1.11

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