Microfluidic titer plate for stratified 3D cell culture.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 23887749)

Published in Lab Chip on September 21, 2013

Authors

Sebastiaan J Trietsch1, Guido D Israëls, Jos Joore, Thomas Hankemeier, Paul Vulto

Author Affiliations

1: Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Einsteinweg 55, 2333CC, Leiden, The Netherlands. trietsch@lacdr.leidenuniv.nl

Articles by these authors

Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics (2007) 6.93

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics (2009) 2.21

Microbial metabolomics with gas chromatography/mass spectrometry. Anal Chem (2006) 2.02

Microbial metabolomics: toward a platform with full metabolome coverage. Anal Biochem (2007) 1.83

Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry. Anal Chem (2006) 1.66

Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets. J Ind Microbiol Biotechnol (2005) 1.54

RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model. J Proteome Res (2008) 1.40

Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples. Mol Cell Proteomics (2010) 1.36

Metabolite identification using automated comparison of high-resolution multistage mass spectral trees. Anal Chem (2012) 1.35

Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis. J Proteome Res (2008) 1.34

Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia. Cancer Res (2006) 1.32

Understanding and classifying metabolite space and metabolite-likeness. PLoS One (2011) 1.29

Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine. Planta Med (2010) 1.25

Analytical strategies in lipidomics and applications in disease biomarker discovery. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.24

Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells. J Biol Chem (2004) 1.22

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics (2010) 1.21

Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. J Proteome Res (2010) 1.19

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery. Anal Bioanal Chem (2012) 1.18

Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics (2006) 1.16

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res (2012) 1.11

Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry. J Chromatogr A (2008) 1.09

Heparan sulfate 6-o-sulfotransferase is essential for muscle development in zebrafish. J Biol Chem (2003) 1.08

Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters. J Lipid Res (2011) 1.08

Elemental composition determination based on MS(n). Bioinformatics (2011) 1.07

Recent methodology in the phytochemical analysis of ginseng. Phytochem Anal (2008) 1.06

Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays. J Proteome Res (2008) 1.06

Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics (2011) 1.06

LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. J Lipid Res (2011) 1.06

Comparative transcriptional profiling and preliminary study on heterosis mechanism of super-hybrid rice. Mol Plant (2010) 1.05

Human metabolomics: strategies to understand biology. Curr Opin Chem Biol (2013) 1.05

Lipidomics of familial longevity. Aging Cell (2013) 1.05

Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry. J Am Soc Mass Spectrom (2011) 1.03

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9. Arterioscler Thromb Vasc Biol (2010) 1.03

Evidence for a minimal eukaryotic phosphoproteome? PLoS One (2007) 1.01

Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy. Planta Med (2006) 1.00

Microfluidic concentration of bacteria by on-chip electrophoresis. Biomicrofluidics (2011) 1.00

A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum. PLoS One (2013) 0.99

The effect of preanalytical factors on stability of the proteome and selected metabolites in cerebrospinal fluid (CSF). J Proteome Res (2009) 0.98

Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem (2008) 0.97

Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots. Chem Pharm Bull (Tokyo) (2011) 0.97

In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS. J Lipid Res (2010) 0.97

Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry. J Chromatogr A (2008) 0.97

Automated pipeline for de novo metabolite identification using mass-spectrometry-based metabolomics. Anal Chem (2013) 0.95

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design. Structure (2008) 0.94

The impact of delayed storage on the measured proteome and metabolome of human cerebrospinal fluid. Clin Chem (2011) 0.93

Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements. PLoS One (2012) 0.93

OMG: Open Molecule Generator. J Cheminform (2012) 0.93

Multiple reaction monitoring assay for pre-eclampsia related calcyclin peptides in formalin fixed paraffin embedded placenta. J Proteome Res (2011) 0.92

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells. J Cell Sci (2012) 0.92

Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification. J Proteome Res (2007) 0.91

Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics. J Proteome Res (2011) 0.91

Fragmentation trees for the structural characterisation of metabolites. Rapid Commun Mass Spectrom (2012) 0.90

Metabolic profiling of ultrasmall sample volumes with GC/MS: from microliter to nanoliter samples. Anal Chem (2010) 0.90

Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins. Curr Med Res Opin (2008) 0.89

Equating, or correction for between-block effects with application to body fluid LC-MS and NMR metabolomics data sets. Anal Chem (2010) 0.89

Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9. Br J Pharmacol (2011) 0.89

The novel gene asb11: a regulator of the size of the neural progenitor compartment. J Cell Biol (2006) 0.89

Semi-automated non-target processing in GC × GC-MS metabolomics analysis: applicability for biomedical studies. Metabolomics (2010) 0.88

Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics. Metabolomics (2009) 0.88

Identification of Novel Phosphorylation Motifs Through an Integrative Computational and Experimental Analysis of the Human Phosphoproteome. J Proteomics Bioinform (2011) 0.87

Higher mass loadability in comprehensive two-dimensional gas chromatography-mass spectrometry for improved analytical performance in metabolomics analysis. J Chromatogr A (2007) 0.87

An efficient hydrophilic interaction liquid chromatography separation of 7 phospholipid classes based on a diol column. J Chromatogr A (2011) 0.87

Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats. Pharm Res (2014) 0.86

Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests. Mol Nutr Food Res (2013) 0.86

Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families. Eur J Hum Genet (2012) 0.86

Kinome profiling of Arabidopsis using arrays of kinase consensus substrates. Plant Methods (2007) 0.86

Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs. OMICS (2008) 0.85

Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes. Biochim Biophys Acta (2013) 0.85

Enrichment of viable bacteria in a micro-volume by free-flow electrophoresis. Lab Chip (2011) 0.85

Simple capillary electrophoresis-mass spectrometry method for complex glycan analysis using a flow-through microvial interface. Anal Chem (2014) 0.84

Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway. J Biol Chem (2013) 0.84

Comprehensive analysis of the metabolome of Pseudomonas putida S12 grown on different carbon sources. Mol Biosyst (2008) 0.84

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation. J Proteome Res (2014) 0.84

Investigation of the marine compound spongistatin 1 links the inhibition of PKCalpha translocation to nonmitotic effects of tubulin antagonism in angiogenesis. FASEB J (2008) 0.84

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture. Lab Chip (2015) 0.82

Capillary electrophoresis-mass spectrometry using a flow-through microvial interface for cationic metabolome analysis. Electrophoresis (2013) 0.82

MetiTree: a web application to organize and process high-resolution multi-stage mass spectrometry metabolomics data. Bioinformatics (2012) 0.81

Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics. Pharmacogenomics (2015) 0.81

Electroosmotic guiding of sample flows in a laminar flow chamber. Electrophoresis (2004) 0.80

Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice. PLoS One (2012) 0.80

Sub-typing of rheumatic diseases based on a systems diagnosis questionnaire. PLoS One (2011) 0.80

Sign constraints improve the detection of differences between complex spectral data sets: LC-IR as an example. Anal Chem (2005) 0.79

Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels. Lab Chip (2012) 0.79

Single-electrolyte isotachophoresis using a nanochannel-induced depletion zone. Anal Chem (2011) 0.79

ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5). Lipids (2011) 0.79

A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues. Chembiochem (2015) 0.78

Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice. PLoS One (2011) 0.78

Pre-processing liquid chromatography/high-resolution mass spectrometry data: extracting pure mass spectra by deconvolution from the invariance of isotopic distribution. Rapid Commun Mass Spectrom (2013) 0.78

Monitoring selectivity in kinase-promoted phosphorylation of densely packed peptide monolayers using label-free electrochemical detection. Langmuir (2011) 0.78

How do metabolites differ from their parent molecules and how are they excreted? J Chem Inf Model (2013) 0.78

Three-phase electroextraction: a new (online) sample purification and enrichment method for bioanalysis. Anal Chem (2013) 0.78

Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids. Electrophoresis (2009) 0.77

Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats. Mol Biosyst (2011) 0.77

Metabolite profiling of human urine by CE-ESI-MS using separation electrolytes at low pH. Electrophoresis (2006) 0.77

Solvent exchange module for LC-NMR hyphenation using machine vision-controlled droplet evaporation. Anal Chem (2013) 0.77

Instrument and process independent binning and baseline correction methods for liquid chromatography-high resolution-mass spectrometry deconvolution. Anal Chim Acta (2012) 0.77