Published in J Control Release on August 03, 2013
Questioning the Use of PEGylation for Drug Delivery. Drug Deliv Transl Res (2013) 0.84
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science (2000) 10.40
Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm (2008) 7.67
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci U S A (1991) 4.85
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol Ther (2010) 3.26
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A (1993) 2.35
The evolution of the protein corona around nanoparticles: a test study. ACS Nano (2011) 2.05
Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding. Biochim Biophys Acta (2007) 1.56
Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo. Adv Drug Deliv Rev (1998) 1.55
Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection. Gene Ther (1999) 1.47
Stability of small unilamellar liposomes in serum and clearance from the circulation: the effect of the phospholipid and cholesterol components. Life Sci (1982) 1.40
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J Control Release (2006) 1.36
Modeling the time evolution of the nanoparticle-protein corona in a body fluid. PLoS One (2010) 1.34
Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells. Biochim Biophys Acta (1998) 1.24
Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J Pharm Sci (2011) 1.24
Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system - The concept of tissue specificity. Adv Drug Deliv Rev (1998) 1.22
Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA. Gene Ther (1997) 1.21
Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics. Int J Pharm (2007) 1.20
Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J Pharm Sci (2000) 1.18
Direct evidence for immiscible cholesterol domains in human ocular lens fiber cell plasma membranes. J Biol Chem (1999) 1.16
Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther (1998) 1.14
Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes. J Pharm Sci (2007) 1.11
Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis. Gene Ther (2000) 1.10
Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry (1996) 1.10
The role of lipid charge density in the serum stability of cationic lipid/DNA complexes. Biochim Biophys Acta (2004) 1.08
In vivo comparative study of lipid/DNA complexes with different in vitro serum stability: effects on biodistribution and tumor accumulation. J Pharm Sci (2008) 1.08
Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol-DOPE/DNA lipoplexes in serum. Biochim Biophys Acta (2009) 1.06
The promise of nucleic acid vaccines. Gene Ther (2000) 1.05
Serum protein MALDI profiling to distinguish upper aerodigestive tract cancer patients from control subjects. J Natl Cancer Inst (2003) 1.03
Receptor versus non-receptor mediated clearance of liposomes. Adv Drug Deliv Rev (1998) 1.00
Cholesterol domains in cationic lipid/DNA complexes improve transfection. Biochim Biophys Acta (2008) 1.00
Influence of cholesterol on the interaction of alpha-crystallin with phospholipids. Exp Eye Res (1998) 0.96
Surface-associated serum proteins inhibit the uptake of phosphatidylserine and poly(ethylene glycol) liposomes by mouse macrophages. Biochim Biophys Acta (2001) 0.96
Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum. Biochim Biophys Acta (2000) 0.95
Effect of cholesterol nanodomains on the targeting of lipid-based gene delivery in cultured cells. Mol Pharm (2010) 0.95
Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles. J Control Release (2004) 0.94
Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition. Int J Pharm (2006) 0.92
Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver. Biochim Biophys Acta (2001) 0.91
Effect of PEGylation on biodistribution and gene silencing of siRNA/lipid nanoparticle complexes. Pharm Res (2012) 0.91
Identification of individual proteins in complex protein mixtures by high-resolution, high-mass-accuracy MALDI TOF-mass spectrometry analysis of in-solution thermal denaturation/enzymatic digestion. Anal Chem (2001) 0.91
The effect of cholesterol domains on PEGylated liposomal gene delivery in vitro. Ther Deliv (2011) 0.89
Lipid mixing between lipoplexes and plasma lipoproteins is a major barrier for intravenous transfection mediated by cationic lipids. J Biol Chem (2005) 0.85
Ligands located within a cholesterol domain enhance gene delivery to the target tissue. J Control Release (2012) 0.83
Cationic liposomes as in vivo delivery vehicles. Curr Med Chem (2003) 0.83
Differential properties of organ-specific serum opsonins for liver and spleen macrophages. Biochim Biophys Acta (1989) 0.83
Cholesterol domains enhance transfection. Ther Deliv (2013) 0.83
Transfection efficiency boost of cholesterol-containing lipoplexes. Biochim Biophys Acta (2012) 0.82
Identification of human plasma proteins that bind to cationic lipid/DNA complex and analysis of their effects on transfection efficiency: implications for intravenous gene transfer. Mol Ther (2003) 0.81
Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles. Int J Nanomedicine (2012) 0.80
The role of lipid charge density in the serum stability of cationic lipid/DNA complexes. Biochim Biophys Acta (2004) 1.08
Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. PLoS One (2012) 1.08
In vivo comparative study of lipid/DNA complexes with different in vitro serum stability: effects on biodistribution and tumor accumulation. J Pharm Sci (2008) 1.08
The stability of lyophilized lipid/DNA complexes during prolonged storage. J Pharm Sci (2004) 1.03
Cholesterol domains in cationic lipid/DNA complexes improve transfection. Biochim Biophys Acta (2008) 1.00
Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free Radic Biol Med (2011) 0.98
Effect of cholesterol nanodomains on the targeting of lipid-based gene delivery in cultured cells. Mol Pharm (2010) 0.95
Metal contaminants promote degradation of lipid/DNA complexes during lyophilization. Biochim Biophys Acta (2006) 0.92
Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse. Biophys J (2005) 0.91
Surface functionalization of exosomes using click chemistry. Bioconjug Chem (2014) 0.90
The effect of cholesterol domains on PEGylated liposomal gene delivery in vitro. Ther Deliv (2011) 0.89
The use of fluorescence resonance energy transfer to monitor dynamic changes of lipid-DNA interactions during lipoplex formation. Biochim Biophys Acta (2003) 0.87
Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes. J Pharm Sci (2004) 0.87
Targeting Her-2+ breast cancer cells with bleomycin immunoliposomes linked to LLO. Mol Pharm (2012) 0.85
Systemic tumor-specific gene delivery. J Control Release (2013) 0.84
Effects of PEGylation on the preservation of cationic lipid/DNA complexes during freeze-thawing and lyophilization. J Pharm Sci (2002) 0.84
Formulation strategies to minimize oxidative damage in lyophilized lipid/DNA complexes during storage. J Pharm Sci (2008) 0.83
Degradation of lyophilized lipid/DNA complexes during storage: the role of lipid and reactive oxygen species. Biochim Biophys Acta (2008) 0.83
Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems. J Pharm Sci (2002) 0.83
Ligands located within a cholesterol domain enhance gene delivery to the target tissue. J Control Release (2012) 0.83
Cholesterol domains enhance transfection. Ther Deliv (2013) 0.83
Immobilization of nonviral vectors during the freezing step of lyophilization. J Pharm Sci (2004) 0.82
An infrared spectroscopic study of the effect of hydration on cationic lipid/DNA complexes. J Pharm Sci (2003) 0.81
Formulation development of freeze-dried oligonucleotide-loaded gelatin nanoparticles. Eur J Pharm Biopharm (2008) 0.81
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry (2011) 0.81
Rationale for the selection of an aerosol delivery system for gene delivery. J Aerosol Med (2006) 0.80
Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano (2017) 0.79
Synergistic effects of surfactants and sugars on lipoplex stability during freeze-drying and rehydration. J Pharm Sci (2009) 0.79
Effects of moisture content on the storage stability of dried lipoplex formulations. J Pharm Sci (2009) 0.78
Ability of spermine to differentiate between DNA sequences--preferential stabilization of A-tracts. Biophys Chem (2006) 0.78
Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins. Curr Cancer Drug Targets (2014) 0.78
An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients. Schizophr Res (2008) 0.75
Long-term storage of lyophilized liposomal formulations. J Pharm Sci (2014) 0.75
Relating toxicity to transfection: using sphingosine to maintain prolonged expression in vitro. Mol Pharm (2014) 0.75
Moisture content impacts the stability of DNA adsorbed onto gold microparticles. J Pharm Sci (2011) 0.75
Application of a ultra performance liquid chromatography method in the determination of DNA quality and stability. J Pharm Sci (2011) 0.75
DNA hydrodynamic degradation controlled by Kolomogorov length scales in pipe flow. J Pharm Sci (2011) 0.75