Published in Climacteric on November 23, 2013
A Clinical Study to Evaluate the Safety of Ospemifene | NCT00566982
New Non-Hormonal Treatment by Radiofrequency for Vulvo-Vaginal Atrophy (ViViA) | NCT03857893
The clinical relevance of the effect of ospemifene on symptoms of vulvar and vaginal atrophy. Climacteric (2014) 0.90
Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy: results of a randomized, placebo-controlled trial. Climacteric (2014) 0.89
Ospemifene's effects on lipids and coagulation factors: a post hoc analysis of phase 2 and 3 clinical trial data. Menopause (2017) 0.76
Endometrial safety of ospemifene: results of the phase 2/3 clinical development program. Menopause (2015) 0.76
Clinical update on the use of ospemifene in the treatment of severe symptomatic vulvar and vaginal atrophy. Int J Womens Health (2016) 0.75
Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. Menopause (2015) 0.75
Safety and efficacy of ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy due to menopause. Clin Interv Aging (2014) 0.75
Ospemifene: A Novel Option for the Treatment of Vulvovaginal Atrophy. J Menopausal Med (2017) 0.75
Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study. Biomed Res Int (2017) 0.75
Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J Natl Cancer Inst (2005) 7.70
Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med (2006) 6.14
Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27
Endometrial cancer and hormone-replacement therapy in the Million Women Study. Lancet (2005) 5.20
Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice. N Engl J Med (2003) 3.46
Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause (2010) 2.26
Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Menopause (2013) 1.83
17beta-estradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis. Menopause (2000) 1.82
Vulvovaginal atrophy. Mayo Clin Proc (2010) 1.81
Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study. Menopause (2010) 1.80
Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database Syst Rev (2006) 1.77
Prevalence and impact of vaginal symptoms among postmenopausal women. J Sex Med (2009) 1.75
Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20-74 years. Ultrasound Obstet Gynecol (2009) 1.70
Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's Health Initiative. Menopause (2011) 1.59
Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene. Menopause (2006) 1.59
Vulvar and vaginal atrophy in postmenopausal women: findings from the REVIVE (REal Women's VIews of Treatment Options for Menopausal Vaginal ChangEs) survey. J Sex Med (2013) 1.56
The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society. Menopause (2007) 1.51
Diagnosis and treatment of atrophic vaginitis. Am Fam Physician (2000) 1.38
Self-reported urogenital symptoms in postmenopausal women: Women's Health Initiative. Maturitas (2004) 1.37
Endometrial safety: a key hurdle for selective estrogen receptor modulators in development. Menopause (2010) 1.27
Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women. Menopause (2008) 1.26
Long-term effects of raloxifene on bone mineral density, bone turnover, and serum lipid levels in early postmenopausal women: three-year data from 2 double-blind, randomized, placebo-controlled trials. Arch Intern Med (2000) 1.17
One-year long-term safety extension study of ospemifene for the treatment of vulvar and vaginal atrophy in postmenopausal women with a uterus. Menopause (2013) 1.03
Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res Treat (2003) 0.98
Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology (2000) 0.96
Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial. Menopause (2003) 0.95
Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women. Maturitas (2002) 0.94
In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer. J Steroid Biochem Mol Biol (2001) 0.92
Topical estrogen therapy in the management of postmenopausal vaginal atrophy: an up-to-date overview. Climacteric (2009) 0.91
Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice. J Steroid Biochem Mol Biol (2005) 0.91
The effect of tamoxifen on the genital tract. Cancer Imaging (2008) 0.89
A study of European womens' experience of the problems of urogenital ageing and its management. Maturitas (1997) 0.88
Prospective study on gynaecological effects of two antioestrogens tamoxifen and toremifene in postmenopausal women. Br J Cancer (2001) 0.86
Designing the ideal selective estrogen receptor modulator--an achievable goal? Menopause (2009) 0.85
Treatment of urogenital atrophy with low-dose estradiol: preliminary results. Menopause (2002) 0.84
Ospemifene, vulvovaginal atrophy, and breast cancer. Maturitas (2013) 0.82
Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements. Mol Cell Endocrinol (2008) 0.82
Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model. Menopause (2012) 0.82
Pharmacology and clinical applications of selective estrogen receptor modulators. Climacteric (2009) 0.82
Not all SERMs are created equal. Menopause (2006) 0.78
Effect of raloxifene on the vaginal epithelium of postmenopausal women. Eur J Obstet Gynecol Reprod Biol (2008) 0.78
The effect of selective estrogen receptor modulators on parameters of the hypothalamic-pituitary-gonadal axis. Ann N Y Acad Sci (2001) 0.77
Depression and anxiety in early pregnancy and risk for preeclampsia. Obstet Gynecol (2000) 2.56
Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet Gynecol (1992) 2.36
Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Menopause (2013) 1.83
Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study. Menopause (2010) 1.80
Prevention of adhesion formation in a laparoscopic mouse model should combine local treatment with peritoneal cavity conditioning. Hum Reprod (2009) 1.72
The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. Fertil Steril (1992) 1.65
The combined effects of physical, sexual, and emotional abuse during childhood: long-term health consequences for women. Child Abuse Negl (1993) 1.56
Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. J Pediatr (1994) 1.52
Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br J Obstet Gynaecol (1993) 1.51
Morbidity and mortality associated with primary and repeat operations for ovarian cancer. Obstet Gynecol (1992) 1.42
Coitus during pregnancy is not related to bacterial vaginosis or preterm birth. Am J Obstet Gynecol (1993) 1.41
Effect of an in vitro fertilization program on serum CA 125, tumor-associated trypsin inhibitor, free beta-subunit of human chorionic gonadotropin, and common alpha-subunit of glycoprotein hormones. Fertil Steril (2000) 1.40
Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther (1993) 1.37
New concepts in dysmenorrhea. Am J Obstet Gynecol (1978) 1.36
Correlation between endometriosis and pelvic pain. J Am Assoc Gynecol Laparosc (1999) 1.32
Evidence of a state of increased insulin resistance in preeclampsia. Metabolism (1999) 1.31
Type 7 adenovirus pneumonia. J Pediatr (1971) 1.25
Coping and the ineffectiveness of coping influence the outcome of in vitro fertilization through stress responses. Psychoneuroendocrinology (1992) 1.22
Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol (2001) 1.19
A study of plasma progesterone, oestradiol-17beta, prolactin and LH levels, and of the luteal phase appearance of the ovaries in patients with endometriosis and infertility. Br J Obstet Gynaecol (1978) 1.16
Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev (2002) 1.16
Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril (1991) 1.13
Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women. Obstet Gynecol (1995) 1.13
Raised serum human chorionic gonadotrophin concentrations in hyperemesis gravidarum. Br Med J (1979) 1.13
CA125 and endometriosis. Hum Reprod Update (1995) 1.13
Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod (1997) 1.12
Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay. Prostaglandins (1980) 1.11
Oxytocin in maternal circulation and amniotic fluid during pregnancy. J Clin Endocrinol Metab (1979) 1.10
Müllerianosis. Histol Histopathol (2007) 1.10
Prostacyclin in the treatment of neonatal pulmonary hypertension. J Pediatr (1985) 1.09
Sexual expression and its determinants in the post-menopausal woman. Maturitas (1984) 1.08
Deeply infiltrating pelvic endometriosis: histology and clinical significance. Fertil Steril (1990) 1.08
Vascular endothelial growth factor in human preterm lung. Am J Respir Crit Care Med (1999) 1.07
Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis). Am J Obstet Gynecol (1995) 1.06
Hyperinsulinemia 17 years after preeclamptic first pregnancy. J Clin Endocrinol Metab (1996) 1.05
Prostacyclin and thromboxane in gynecology and obstetrics. Am J Obstet Gynecol (1985) 1.04
One-year long-term safety extension study of ospemifene for the treatment of vulvar and vaginal atrophy in postmenopausal women with a uterus. Menopause (2013) 1.03
Reduced pain tolerance during and after pregnancy in women suffering from fear of labor. Pain (2001) 1.03
New aspects of the pathophysiology of endometriosis and associated infertility. J Reprod Med (1980) 1.02
Prostacyclin and thromboxane in diabetes. Br Med J (Clin Res Ed) (1981) 1.01
Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertil Steril (2001) 0.99
Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. Gut (2003) 0.98
Nitric oxide production with preeclampsia. Obstet Gynecol (1999) 0.98
Origin of peritoneal fluid in women: an ovarian exudation product. Br J Obstet Gynaecol (1980) 0.98
Effect of training on endoscopic intracorporeal knot tying. Hum Reprod (1997) 0.97
Effect of nicotine on fetal prostacyclin and thromboxane in humans. Obstet Gynecol (1985) 0.95
Ultra-low-dose estradiol and norethisterone acetate: effective menopausal symptom relief. Climacteric (2007) 0.95
Reactive oxygen species and adhesion formation: clinical implications in adhesion prevention. Hum Reprod (2003) 0.94
A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Obstet Gynecol (1991) 0.94
A prospective study of 63 couples with a history of recurrent spontaneous abortion: contributing factors and outcome of subsequent pregnancies. Hum Reprod (1993) 0.94
Prevalence of oligomenorrhea and amenorrhea in a college population. Am J Obstet Gynecol (1982) 0.94
Transforming growth factor-beta activity is increased in peritoneal fluid from women with endometriosis. Obstet Gynecol (1994) 0.93
A dose response relation between improved lactation and metoclopramide. Lancet (1981) 0.93
Effects of intravenous isoxsuprine and ritodrine, with and without concomitant dexamethasone, on fetoplacental and pituitary hormones and cyclic adenosine monophosphate during late pregnancy. Am J Obstet Gynecol (1978) 0.93
Plasma prostacyclin from birth to adolescence. Arch Dis Child (1982) 0.92
Adhesion formation in intubated rabbits increases with high insufflation pressure during endoscopic surgery. Hum Reprod (2000) 0.92
Factors associated with fear of delivery in second pregnancies. Obstet Gynecol (1999) 0.92
Association between bone, body composition and strength in premenarcheal girls and postmenopausal women. Ann Hum Biol (2004) 0.92
Development of a model of retrograde menstruation in baboons (Papio anubis). Fertil Steril (1994) 0.91
Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. Prostaglandins Leukot Med (1982) 0.91
Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors. J Reprod Med (1985) 0.91
Prevalence and laparoscopic appearance of spontaneous endometriosis in the baboon (Papio anubis, Papio cynocephalus). Biol Reprod (1991) 0.91
Long-term safety of ospemifene (52-week extension) in the treatment of vulvar and vaginal atrophy in hysterectomized postmenopausal women. Maturitas (2013) 0.90
Myth or fact: can women self-diagnose pregnancy? J Med Soc N J (1984) 0.90
677 C-->T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia. Obstet Gynecol (2000) 0.90
Anti-prostglandin therapy in prevention of side-effects of intrauterine contraceptive devices. Lancet (1978) 0.89
Effect of dexamethasone on blood levels of ACTH, cortisol, progesterone, estradiol and estriol during late pregnancy. Int J Gynaecol Obstet (1976) 0.89
Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy: results of a randomized, placebo-controlled trial. Climacteric (2014) 0.89
The effects of indomethacin and a beta-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: a randomized double-blind study. Am J Obstet Gynecol (1991) 0.89
Lipid peroxides, prostacyclin, and thromboxane A2 in runners during acute exercise. Med Sci Sports Exerc (1984) 0.89
Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and the North American Menopause Society. Maturitas (2014) 0.88
Increased plasma immunoreactive 6-keto-prostaglandin F1 alpha levels in newborns with idiopathic respiratory distress syndrome. Pediatr Res (1982) 0.88
Angiogenic activity of peritoneal fluid from women with endometriosis. Fertil Steril (1993) 0.88
Biochemical characterization of peritoneal fluid in women during the menstrual cycle. J Clin Endocrinol Metab (1980) 0.88
Prostaglandins in contact urticaria induced by benzoic acid. Acta Derm Venereol (1983) 0.88
Evidence of a lack of effect of a phytoestrogen regimen on the levels of C-reactive protein, E-selectin, and nitrate in postmenopausal women. J Clin Endocrinol Metab (2003) 0.88
Evaluation of a vaginal moisturizer in baboons with decreasing ovarian function. Lab Anim Sci (1997) 0.88
Hypoxaemia induced by CO(2) or helium pneumoperitoneum is a co-factor in adhesion formation in rabbits. Hum Reprod (2000) 0.88
Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass. J Thorac Cardiovasc Surg (1981) 0.88
Metabolism of a new synthetic progestagen, Org 2969, in female volunteers. Pharmacokinetics after an oral dose. Eur J Clin Pharmacol (1979) 0.88
Individual differences in equol production capability modulate blood pressure in tibolone-treated postmenopausal women: lack of effect of soy supplementation. Climacteric (2007) 0.88
Unbound vascular endothelial growth factor and its receptors in breast, human milk, and newborn intestine. Am J Clin Nutr (2000) 0.87
Letter: Congenital anomalies and clomiphene. Lancet (1975) 0.87
Serial laparoscopies over 30 months show that endometriosis in captive baboons (Papio anubis, Papio cynocephalus) is a progressive disease. Fertil Steril (1996) 0.87
Twin pregnancy. The role of active management during pregnancy and delivery. Acta Obstet Gynecol Scand Suppl (1975) 0.87
Prostacyclin, thromboxane and prostaglandin F2 alpha in suction blister fluid of human skin: effect of systemic aspirin and local glucocorticosteroid treatment. Life Sci (1981) 0.87
Prospective study on gynaecological effects of two antioestrogens tamoxifen and toremifene in postmenopausal women. Br J Cancer (2001) 0.86
Prolactin concentration in vaginal fluid: a new method for diagnosing ruptured membranes. Br J Obstet Gynaecol (1981) 0.86
Primary and myoma-associated menorrhagia: role of prostaglandins and effects of ibuprofen. Br J Obstet Gynaecol (1986) 0.86
The role of ground state complexation in the electron transfer quenching of methylene blue fluorescence by purine nucleotides. Photochem Photobiol (1991) 0.86
Effect of temperature upon adhesion formation in a laparoscopic mouse model. Hum Reprod (2004) 0.86
Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women. Gynecol Endocrinol (2004) 0.86
Human vascular endothelial cells produce tumor necrosis factor-alpha in response to proinflammatory cytokine stimulation. Crit Care Med (1999) 0.85
Expression of cyclooxygenase-2 and prostanoid receptors by human myometrium. J Clin Endocrinol Metab (2000) 0.85
Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and The North American Menopause Society. Climacteric (2014) 0.85
Maternal origin of nucleated erythrocytes in peripheral venous blood of pregnant women. Hum Genet (1995) 0.84
Sulpiride improves inadequate lactation. Br Med J (Clin Res Ed) (1982) 0.84
The prevalence of spontaneous endometriosis in the baboon (Papio anubis, Papio cynocephalus) increases with the duration of captivity. Acta Obstet Gynecol Scand (1996) 0.84
Comparison between naproxen tablets and suppositories in primary dysmenorrhea. Prostaglandins (1980) 0.84
Leptin during and after preeclamptic or normal pregnancy: its relation to serum insulin and insulin sensitivity. Metabolism (2000) 0.84