Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3898320)

Published in Oncogene on September 02, 2013

Authors

F Wolff1, A Loipetzberger1, W Gruber1, H Esterbauer2, F Aberger1, A M Frischauf1

Author Affiliations

1: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
2: Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria.

Articles cited by this

The protein kinase complement of the human genome. Science (2002) 35.36

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24

Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94

Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43

Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med (2012) 6.90

Adenosine receptors as therapeutic targets. Nat Rev Drug Discov (2006) 6.15

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell (2000) 6.08

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature (1996) 5.69

Hedgehog: functions and mechanisms. Genes Dev (2008) 5.69

Patched acts catalytically to suppress the activity of Smoothened. Nature (2002) 4.69

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell (1997) 4.43

Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med (2012) 4.19

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development (1999) 4.06

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res (2011) 4.05

Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ (2007) 3.55

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem (1999) 3.25

The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol (2007) 3.14

Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol (2006) 3.06

Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet (2011) 2.93

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell (2002) 2.73

GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer (2006) 2.63

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47

Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell (2011) 2.31

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev (2003) 2.12

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci U S A (2005) 2.02

Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol (1998) 2.00

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Oncogene (2002) 1.99

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res (2004) 1.98

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A (2009) 1.95

Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology (2005) 1.83

Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol (2006) 1.82

GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol (2004) 1.76

Imiquimod: mode of action. Br J Dermatol (2007) 1.70

Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development (2003) 1.68

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest (2012) 1.66

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65

Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem (2003) 1.65

Purines, purinergic receptors, and cancer. Cancer Res (2012) 1.61

Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice. J Neuropathol Exp Neurol (1985) 1.52

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol (2008) 1.48

The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol (2006) 1.48

Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development (2004) 1.44

Treatment of facial Basal cell carcinoma: a review. J Skin Cancer (2011) 1.41

Facial basal cell carcinoma. BMJ (2012) 1.41

Gli genes in development and cancer. Oncogene (1999) 1.33

High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood. Proc Natl Acad Sci U S A (2001) 1.32

Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. J Natl Cancer Inst (2003) 1.25

Hedgehog pathway inhibition and the race against tumor evolution. J Cell Biol (2012) 1.24

Adenosine receptors and cancer. Biochim Biophys Acta (2010) 1.23

Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes. Genomics (2006) 1.21

Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? Cancer Cell (2008) 1.19

Oral hedgehog-pathway inhibitors for basal-cell carcinoma. N Engl J Med (2012) 1.19

Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumors. Exp Dermatol (2006) 1.16

Vismodegib. Nat Rev Drug Discov (2012) 1.16

Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1. PLoS One (2013) 1.04

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium. PLoS One (2010) 1.00

Adenosine receptors: what we know and what we are learning. Curr Top Med Chem (2010) 0.93

Imiquimod, a Toll-like receptor-7 agonist, induces perforin in cytotoxic T lymphocytes in vitro. Mol Immunol (2004) 0.93

Efficient manipulation of Hedgehog/GLI signaling using retroviral expression systems. Methods Mol Biol (2007) 0.91

Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration. J Biol Chem (2012) 0.80

Successful treatment and management of large superficial basal cell carcinomas with topical imiquimod 5% cream: a case series and review. J Dermatolog Treat (2011) 0.80

TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells. Cancer Lett (2013) 0.76