PubRank

Leonard S Jefferson

Author PubWeight™ 116.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 2002 3.81
2 Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes 2006 3.31
3 The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 2002 3.22
4 Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol 2002 2.62
5 Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 2006 2.38
6 Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 2005 1.83
7 Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem 2006 1.78
8 Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. J Biol Chem 2004 1.77
9 Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J Physiol 2003 1.75
10 ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun 2008 1.63
11 Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. J Biol Chem 2004 1.59
12 Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol (1985) 2002 1.58
13 Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 2007 1.52
14 Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol 2006 1.48
15 Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab 2002 1.48
16 Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab 2005 1.46
17 New functions for amino acids: effects on gene transcription and translation. Am J Clin Nutr 2006 1.44
18 Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Am J Physiol Endocrinol Metab 2006 1.42
19 Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab 2010 1.36
20 Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. J Nutr 2009 1.35
21 Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab 2003 1.34
22 Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs. Am J Physiol Endocrinol Metab 2005 1.33
23 AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells. Am J Physiol Endocrinol Metab 2007 1.33
24 Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. Am J Physiol Endocrinol Metab 2005 1.31
25 Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation. Proc Natl Acad Sci U S A 2007 1.30
26 Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 2002 1.28
27 Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. J Biol Chem 2011 1.24
28 eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics 2009 1.22
29 Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin. Curr Opin Clin Nutr Metab Care 2004 1.21
30 Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res 2010 1.21
31 Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Am J Physiol Endocrinol Metab 2002 1.20
32 Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J Nutr 2004 1.20
33 The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am J Physiol Endocrinol Metab 2012 1.20
34 Control of protein synthesis by amino acid availability. Curr Opin Clin Nutr Metab Care 2002 1.19
35 The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. Int J Biochem Cell Biol 2004 1.17
36 Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J Biol Chem 2010 1.15
37 Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab 2004 1.13
38 Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle. Am J Physiol Endocrinol Metab 2006 1.12
39 Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. Am J Physiol Cell Physiol 2010 1.12
40 Amino acids as regulators of gene expression. Nutr Metab (Lond) 2004 1.07
41 Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am J Physiol Endocrinol Metab 2003 1.07
42 Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J Biol Chem 2012 1.07
43 Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs. Am J Physiol Endocrinol Metab 2003 1.07
44 Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proc Nutr Soc 2004 1.06
45 Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). Cell Signal 2013 1.05
46 Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells. Am J Physiol Renal Physiol 2006 1.05
47 Role of amino acids in the translational control of protein synthesis in mammals. Semin Cell Dev Biol 2004 1.05
48 Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab 2003 1.04
49 Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs. J Nutr 2004 1.03
50 Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. Am J Physiol Endocrinol Metab 2007 1.02
51 Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. Am J Physiol Endocrinol Metab 2004 1.02
52 Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. J Biol Chem 2003 1.00
53 Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs. Am J Physiol Endocrinol Metab 2005 1.00
54 ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. Am J Physiol Cell Physiol 2011 0.99
55 Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. Am J Physiol Endocrinol Metab 2004 0.99
56 Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver. Am J Physiol Endocrinol Metab 2009 0.97
57 Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids. Biochem Biophys Res Commun 2004 0.93
58 Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes 2010 0.93
59 Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle. Am J Physiol Endocrinol Metab 2002 0.93
60 Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver. Hepatology 2004 0.92
61 Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise. J Appl Physiol (1985) 2003 0.92
62 Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free Radic Biol Med 2009 0.91
63 Meal feeding alters translational control of gene expression in rat liver. J Nutr 2005 0.91
64 Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis. Int J Biochem Cell Biol 2008 0.90
65 Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy 2012 0.90
66 Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. J Biol Chem 2012 0.90
67 Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Prog Nucleic Acid Res Mol Biol 2006 0.89
68 Transcriptomic comparison of the retina in two mouse models of diabetes. J Ocul Biol Dis Infor 2009 0.88
69 Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism. Diabetes 2013 0.88
70 Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. Am J Physiol Endocrinol Metab 2011 0.87
71 Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts. Am J Physiol Heart Circ Physiol 2005 0.87
72 Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis. Am J Physiol Endocrinol Metab 2010 0.86
73 Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. Am J Physiol Endocrinol Metab 2005 0.86
74 Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. J Biol Chem 2011 0.86
75 Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein. J Nutr 2005 0.86
76 Inhibition of mammalian translation initiation by volatile anesthetics. Am J Physiol Endocrinol Metab 2006 0.85
77 The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases. Biochem J 2002 0.85
78 SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling. Proc Natl Acad Sci U S A 2013 0.85
79 Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology 2003 0.85
80 Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion. J Appl Physiol (1985) 2006 0.84
81 Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. J Pineal Res 2008 0.83
82 Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein. Cancer Res 2008 0.82
83 Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. Am J Physiol Endocrinol Metab 2006 0.82
84 Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade. Biochem Biophys Res Commun 2012 0.82
85 Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy. Exerc Sport Sci Rev 2003 0.82
86 Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatr Res 2003 0.82
87 Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. Am J Clin Nutr 2008 0.81
88 Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia. Pediatr Res 2008 0.81
89 REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade. Biochem Biophys Res Commun 2011 0.81
90 Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats. J Exp Biol 2011 0.81
91 The activated glucocorticoid receptor modulates presumptive autoregulation of ribosomal protein S6 protein kinase, p70 S6K. J Biol Chem 2001 0.80
92 Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch. Am J Physiol Cell Physiol 2012 0.80
93 Beta -oxidation of free fatty acids is required to maintain translational control of protein synthesis in heart. Am J Physiol Endocrinol Metab 2002 0.80
94 Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. Am J Physiol Endocrinol Metab 2008 0.79
95 Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase. Int J Biochem Cell Biol 2005 0.79
96 AMPK represses TOP mRNA translation but not global protein synthesis in liver. Biochem Biophys Res Commun 2008 0.79
97 Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis. Pediatr Res 2010 0.79
98 ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. Hepatology 2015 0.78
99 Tissue-specific regulation of protein synthesis by insulin and free fatty acids. Am J Physiol Endocrinol Metab 2003 0.77
100 Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells. Int J Oncol 2007 0.75
101 Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon. Biochem Biophys Res Commun 2013 0.75
102 A microtiter plate assay for assessing the interaction of eukaryotic initiation factor eIF4E with eIF4G and eIF4E binding protein-1. Anal Biochem 2004 0.75