Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3776567)

Published in Clin Pharmacol on September 02, 2013

Authors

Shi-Yan Li1, Yizhen Liu

Author Affiliations

1: Cancer Research Institute, Scott and white Healthcare, Temple, TX, USA.

Associated clinical trials:

Phase II, 2nd Line Melanoma - RAND Monotherapy | NCT00612664

Safety, Tolerability, Pharmacokinetics, and Immunoregulatory Study of Urelumab (BMS-663513) in Subjects With Advanced and/or Metastatic Solid Tumors and Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma | NCT01471210

Combination Study of Urelumab and Rituximab in Patients With B-cell Non-Hodgkins Lymphoma | NCT01775631

Study of BMS-663513 in Patients With Advanced Cancer | NCT00309023

A Study of BMS-663513 in Combination With Chemoradiation in Subjects With Non Small Cell Lung Carcinoma (NSCLC) | NCT00461110

Combination of Anti-CD137 & Ipilimumab in Patients With Melanoma | NCT00803374

A Study of BMS-663513 Administered in Combination With Chemotherapy to Subjects With Advanced Solid Malignancies | NCT00351325

Articles cited by this

Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer (2007) 5.65

Human T cell responses against melanoma. Annu Rev Immunol (2006) 4.99

Regulatory T cells in tumor immunity. Int J Cancer (2010) 4.53

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89

Adoptive T cell therapy for cancer in the clinic. J Clin Invest (2007) 3.45

A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol (1994) 2.65

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest (2002) 2.21

Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med (2006) 2.10

Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol (2010) 2.00

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol (1999) 1.95

Update on immunotherapy for melanoma. J Natl Compr Canc Netw (2006) 1.52

Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother (2011) 1.46

Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res (2006) 1.45

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci (2008) 1.42

Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med (1999) 1.37

Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res (2002) 1.36

4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J Immunol (2002) 1.29

Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood (2003) 1.27

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res (2011) 1.23

Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res (2004) 1.22

The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol Rev (2008) 1.22

Immunotherapy of cancer with 4-1BB. Mol Cancer Ther (2012) 1.19

Role of 4-1BB:4-1BB ligand in cancer immunotherapy. Cancer Gene Ther (2004) 1.10

From cancer immunosurveillance to cancer immunotherapy. Immunol Rev (2007) 1.10

Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation. Cancer Res (2001) 1.09

Targeting the immune system in cancer. Curr Pharm Biotechnol (2009) 1.04

Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells. Clin Cancer Res (2005) 0.96

Melanoma as a model tumour for immuno-oncology. Ann Oncol (2012) 0.95

4-1BB as a therapeutic target for human disease. Adv Exp Med Biol (2009) 0.90

Combination therapy with cisplatin and anti-4-1BB: synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity. Cancer Res (2008) 0.90

Immunotherapy with dendritic cells for cancer. Adv Drug Deliv Rev (2007) 0.89

How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma. Ann Oncol (2012) 0.89

Historical review of melanoma treatment and outcomes. Clin Dermatol (2013) 0.86

Immunotherapy with agonistic anti-CD137: two sides of a coin. Cell Mol Immunol (2004) 0.85

Eradication of established renal cell carcinoma by a combination of 5-fluorouracil and anti-4-1BB monoclonal antibody in mice. Int J Cancer (2008) 0.85

The therapeutic potential of 4-1BB (CD137) in cancer. Curr Cancer Drug Targets (2005) 0.84

Immunotherapy of melanoma. Asia Pac J Clin Oncol (2010) 0.83

Immune correlates of melanoma survival in adoptive cell therapy. Oncoimmunology (2013) 0.82

Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice. J Immunother (2000) 0.79

CD137 enhances cytotoxicity of CD3(+)CD56(+) cells and their capacities to induce CD4(+) Th1 responses. Biomed Pharmacother (2008) 0.79

Melanoma immunotherapy: historical precedents, recent successes and future prospects. Immunotherapy (2013) 0.78

The evolution in melanoma treatment as a reflection of precision-oriented medicine. Oncol Lett (2012) 0.76