| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion.
|
Am J Physiol Cell Physiol
|
2006
|
2.05
|
|
2
|
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
|
J Biol Chem
|
2007
|
1.85
|
|
3
|
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction.
|
J Biol Chem
|
2004
|
1.73
|
|
4
|
PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis.
|
Mol Biol Cell
|
2003
|
1.62
|
|
5
|
Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity.
|
J Biol Chem
|
2001
|
1.44
|
|
6
|
Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation.
|
Endocrinology
|
2004
|
1.41
|
|
7
|
Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.
|
J Biol Chem
|
2001
|
1.40
|
|
8
|
Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells.
|
J Biol Chem
|
2002
|
1.38
|
|
9
|
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
|
J Biol Chem
|
2011
|
1.32
|
|
10
|
A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity.
|
Mol Cell Biol
|
2004
|
1.29
|
|
11
|
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
|
J Biol Chem
|
2003
|
1.24
|
|
12
|
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
|
J Mol Biol
|
2008
|
1.24
|
|
13
|
The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.
|
Cancer Res
|
2007
|
1.13
|
|
14
|
Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects.
|
Endocrinology
|
2002
|
1.10
|
|
15
|
ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.
|
Exp Cell Res
|
2007
|
1.08
|
|
16
|
Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate.
|
J Am Chem Soc
|
2006
|
1.05
|
|
17
|
Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway.
|
J Biol Chem
|
2004
|
1.05
|
|
18
|
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
|
J Biol Chem
|
2010
|
1.03
|
|
19
|
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.
|
Biochem Biophys Res Commun
|
2009
|
1.02
|
|
20
|
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
|
J Biol Chem
|
2009
|
1.00
|
|
21
|
Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.
|
Mol Cell Biol
|
2006
|
0.97
|
|
22
|
Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.
|
J Biol Chem
|
2009
|
0.97
|
|
23
|
Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin.
|
J Biol Chem
|
2008
|
0.96
|
|
24
|
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
|
Am J Physiol Cell Physiol
|
2012
|
0.96
|
|
25
|
PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin.
|
J Biol Chem
|
2002
|
0.91
|
|
26
|
Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
|
Am J Physiol Endocrinol Metab
|
2013
|
0.82
|
|
27
|
Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.
|
Traffic
|
2014
|
0.78
|
|
28
|
The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.
|
Biochem Biophys Res Commun
|
2013
|
0.78
|
|
29
|
cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.
|
Mol Pharmacol
|
2013
|
0.78
|
|
30
|
Analysis of potential binding of the recombinant Rab9 effector p40 to phosphoinositide-enriched synthetic liposomes.
|
Methods Enzymol
|
2005
|
0.76
|