Takao Hamakubo

Author PubWeight™ 115.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev 2005 5.50
2 Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A 2003 4.03
3 Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. Cancer Res 2004 2.34
4 A wave of nascent transcription on activated human genes. Proc Natl Acad Sci U S A 2009 2.18
5 Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem 2004 2.05
6 Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol 2009 1.91
7 G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature 2012 1.82
8 The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 2009 1.78
9 Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris. Arterioscler Thromb Vasc Biol 2006 1.72
10 Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. Blood 2009 1.68
11 COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A 2009 1.67
12 G protein-dependent basal and evoked endothelial cell vWF secretion. Blood 2013 1.39
13 Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer. Cancer Res 2008 1.35
14 A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage. J Atheroscler Thromb 2004 1.34
15 Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl Recept 2005 1.32
16 Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mol Cell Biol 2012 1.26
17 Association of active gamma-secretase complex with lipid rafts. J Lipid Res 2005 1.24
18 Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun 2006 1.21
19 Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions. Arterioscler Thromb Vasc Biol 2002 1.20
20 The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells. J Atheroscler Thromb 2002 1.20
21 Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. J Atheroscler Thromb 2005 1.18
22 Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells. Biochem Biophys Res Commun 2008 1.16
23 Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arterioscler Thromb Vasc Biol 2006 1.14
24 Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 2007 1.13
25 Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J 2011 1.13
26 Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients. Neurosci Lett 2009 1.13
27 Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. Clin Cancer Res 2006 1.11
28 Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. J Biol Chem 2013 1.11
29 Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells. J Biol Chem 2009 1.11
30 Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A 2006 1.10
31 Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. J Biol Chem 2004 1.10
32 Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol Cell Biol 2007 1.10
33 Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J Biol Chem 2004 1.09
34 Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms. Eur J Cell Biol 2011 1.08
35 The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J Atheroscler Thromb 2002 1.08
36 Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron 2010 1.07
37 Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem 2008 1.06
38 Genome-wide gene expression analysis for induced ischemic tolerance and delayed neuronal death following transient global ischemia in rats. J Cereb Blood Flow Metab 2004 1.06
39 Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Mol Cell Biol 2008 1.04
40 Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis. Pathol Int 2011 1.03
41 Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats. Nucl Recept 2003 1.02
42 A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor. J Biol Chem 2003 1.02
43 Gene expression profile during acute rejection in rat-to-mouse concordant cardiac xenograft by means of DNA microarray. Transpl Int 2002 1.01
44 Global analysis of RNA expression profile in human vascular cells treated with statins. J Atheroscler Thromb 2004 0.99
45 A novel tumor-targeted therapy using a claudin-4-targeting molecule. Mol Pharmacol 2009 0.98
46 The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps. Mol Cell Proteomics 2012 0.96
47 Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. J Biol Chem 2010 0.96
48 Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus. J Immunol Methods 2007 0.96
49 Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface. J Biol Chem 2008 0.96
50 The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest 2009 0.94
51 The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma. Histopathology 2011 0.93
52 Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4. J Neuroimmunol 2013 0.91
53 Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. FEBS Lett 2010 0.91
54 Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. J Biol Chem 2012 0.89
55 Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals. Neurosci Lett 2010 0.89
56 Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob. J Biol Chem 2012 0.89
57 A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide. Biochem Pharmacol 2010 0.88
58 Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. Pathol Int 2007 0.88
59 Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha. FEBS Lett 2006 0.88
60 Expression of the mouse PR domain protein Prdm8 in the developing central nervous system. Gene Expr Patterns 2009 0.87
61 Analysis of PPAR alpha function in human kidney cell line using siRNA. Nucleic Acids Symp Ser (Oxf) 2006 0.87
62 Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. J Biol Chem 2009 0.87
63 Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. FEBS Lett 2008 0.86
64 Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. Biochem J 2010 0.85
65 Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis. J Reprod Immunol 2008 0.85
66 Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps. Front Immunol 2012 0.85
67 Expression of liver X receptor alpha in rat fetal tissues at different developmental stages. J Histochem Cytochem 2007 0.84
68 Expression of hepatocyte nuclear factor 4 alpha in primary ovarian mucinous tumors. Pathol Int 2008 0.84
69 Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin. Protein Sci 2013 0.84
70 Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma. Pathol Int 2009 0.83
71 Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages. Cell Immunol 2007 0.82
72 Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells. Cell Biol Int 2005 0.82
73 Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments. J Biochem 2008 0.82
74 Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits. Atherosclerosis 2002 0.81
75 Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J Biotechnol 2008 0.81
76 Expression of the LXRalpha protein in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2004 0.81
77 Recovery of functional peptide transporter PepT1 in budded baculovirus fraction. Protein Expr Purif 2005 0.81
78 Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS One 2011 0.81
79 Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to claudin-4 and reversibly modulate tight junctions in vitro. Biochem Biophys Res Commun 2011 0.80
80 A novel monoclonal antibody against the C-terminal region of aquaporin-4. Monoclon Antib Immunodiagn Immunother 2013 0.80
81 Immunostaining of oxidized DJ-1 in human and mouse brains. J Neuropathol Exp Neurol 2014 0.80
82 Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray. Transplantation 2002 0.80
83 Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade. Physiol Genomics 2003 0.80
84 A simple detection method for low-affinity membrane protein interactions by baculoviral display. PLoS One 2008 0.80
85 Extensive oligonucleotide microarray transcriptome analysis of the rat cerebral artery and arachnoid tissue. J Atheroscler Thromb 2002 0.79
86 Protein expression of nuclear receptors in human and murine tissues. Pathol Int 2009 0.79
87 Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol 2013 0.79
88 Mucosal vaccination using claudin-4-targeting. Biomaterials 2010 0.79
89 Identification and characterization of the X-dimer of human P-cadherin: implications for homophilic cell adhesion. Biochemistry 2014 0.79
90 Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex. Anal Bioanal Chem 2014 0.78
91 Evaluation of the asparagine synthetase level in leukemia cells by monoclonal antibodies. Hybridoma (Larchmt) 2012 0.78
92 Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells. Biochem Biophys Res Commun 2009 0.78
93 Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials 2012 0.78
94 The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice. Biomaterials 2011 0.78
95 Functional reconstitution of olfactory receptor complex on baculovirus. Chem Senses 2012 0.77
96 Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage. Pathol Int 2009 0.77
97 Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. Mol Biosyst 2012 0.77
98 Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor. Monoclon Antib Immunodiagn Immunother 2014 0.77
99 Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun 2011 0.77
100 A novel screening system for claudin binder using baculoviral display. PLoS One 2011 0.77
101 A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells. J Immunol Methods 2011 0.77
102 Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles. FEBS Lett 2009 0.76
103 Transcriptional activation by hypoxia and low-density lipoprotein loading in cultured vascular smooth muscle cells. J Atheroscler Thromb 2007 0.76
104 Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. Biosci Biotechnol Biochem 2012 0.76
105 A novel method for viral display of ER membrane proteins on budded baculovirus. Biochem Biophys Res Commun 2003 0.76
106 Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element. J Biochem 2013 0.76
107 Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses. Protein Sci 2015 0.76
108 Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity. Cell Signal 2013 0.75
109 Establishment of a monoclonal antibody for human LXRalpha: Detection of LXRalpha protein expression in human macrophages. Nucl Recept 2003 0.75
110 A baculoviral display system to assay viral entry. Biol Pharm Bull 2013 0.75
111 Correction: Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex. Development 2017 0.75
112 Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells. Nucleic Acids Symp Ser (Oxf) 2007 0.75
113 A simple hybridoma screening method for high-affinity monoclonal antibodies using the signal ratio obtained from time-resolved fluorescence assay. Anal Biochem 2006 0.75
114 Visual observation of avidin-biotin affinity by fluorescent G4.5 poly(amidoamine) dendrimer. Colloids Surf B Biointerfaces 2010 0.75