Published in Mass Spectrom Rev on September 30, 2013
Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. Am J Surg Pathol (2014) 1.01
Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity. Aging Dis (2016) 0.88
Identification of protein succination as a novel modification of tubulin. Biochem J (2014) 0.80
Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications. Biochem Insights (2016) 0.79
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Mol Cell Proteomics (2015) 0.79
The Succinated Proteome of FH-Mutant Tumours. Metabolites (2014) 0.78
Pheochromocytoma: The First Metabolic Endocrine Cancer. Clin Cancer Res (2016) 0.78
Recent advances in proteomic studies of adipose tissues and adipocytes. Int J Mol Sci (2015) 0.78
Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction. J Bioenerg Biomembr (2015) 0.77
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis. Cell Chem Biol (2017) 0.75
Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex. Front Mol Neurosci (2016) 0.75
The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes. Biochim Biophys Acta (2014) 0.75
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes. Cell Rep (2017) 0.75
Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space. Mol Biol Cell (2017) 0.75
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J Am Soc Mass Spectrom (1994) 45.51
Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat Biotechnol (2001) 28.01
The pathobiology of diabetic complications: a unifying mechanism. Diabetes (2005) 14.96
Mechanisms linking obesity with cardiovascular disease. Nature (2006) 9.07
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature (2000) 7.10
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem (2009) 5.80
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet (2005) 4.12
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell (2012) 3.90
Spectral probabilities and generating functions of tandem mass spectra: a strike against decoy databases. J Proteome Res (2008) 3.84
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain (2011) 3.38
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00
Clinical review: The role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab (2008) 3.00
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell (2011) 2.78
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem (2008) 2.72
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell (2007) 2.69
Mouse proteome analysis. Genome Res (2003) 2.69
The generating function of CID, ETD, and CID/ETD pairs of tandem mass spectra: applications to database search. Mol Cell Proteomics (2010) 2.64
The nature of the amino acid residues involved in the inactivation of ribonuclease by iodoacetate. J Biol Chem (1959) 2.56
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol (2011) 2.45
DeconMSn: a software tool for accurate parent ion monoisotopic mass determination for tandem mass spectra. Bioinformatics (2008) 2.38
Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses. Anal Chem (2007) 2.38
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab (2008) 1.85
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med (2011) 1.81
S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response. Mol Interv (2007) 1.71
Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc (2009) 1.71
The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol (2012) 1.64
Regulation of signal transduction through protein cysteine oxidation. Antioxid Redox Signal (2006) 1.64
Transcriptional and post-translational regulation of adiponectin. Biochem J (2009) 1.52
A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci U S A (2008) 1.48
S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate. Arch Biochem Biophys (2006) 1.46
Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress. J Biol Chem (2007) 1.38
Oxidation of zinc finger transcription factors: physiological consequences. Antioxid Redox Signal (2001) 1.35
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab (2012) 1.35
High-pH reversed-phase chromatography with fraction concatenation for 2D proteomic analysis. Expert Rev Proteomics (2012) 1.35
Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase. Biochemistry (2003) 1.30
Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr (2008) 1.25
The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer. Antioxid Redox Signal (2010) 1.23
Enrichment and analysis of nonenzymatically glycated peptides: boronate affinity chromatography coupled with electron-transfer dissociation mass spectrometry. J Proteome Res (2007) 1.17
Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin. J Biol Chem (2009) 1.14
Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease. J Proteome Res (2003) 1.11
Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk. Pharmacol Res (2007) 1.08
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency. Cell Rep (2013) 1.08
The emerging role of fumarate as an oncometabolite. Front Oncol (2012) 1.08
Formation, reactivity, and detection of protein sulfenic acids. Chem Res Toxicol (2010) 1.05
Treatment of psoriasis with fumaric acid esters (Fumaderm). J Dtsch Dermatol Ges (2007) 1.05
Glyceraldehyde 3-phosphate dehydrogenase is unlikely to mediate hydrogen peroxide signaling: studies with a novel anti-dimedone sulfenic acid antibody. Antioxid Redox Signal (2010) 1.04
Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione. Neurochem Int (2010) 1.03
Glutathionylation of cytosolic glyceraldehyde-3-phosphate dehydrogenase from the model plant Arabidopsis thaliana is reversed by both glutaredoxins and thioredoxins in vitro. Biochem J (2012) 1.00
Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes. Ann N Y Acad Sci (2008) 0.99
The clinical implications of blood adiponectin in cardiometabolic disorders. J Formos Med Assoc (2009) 0.98
Strong cation exchange (SCX) based analytical methods for the targeted analysis of protein post-translational modifications. Curr Opin Biotechnol (2010) 0.97
Succination of proteins in diabetes. Free Radic Res (2010) 0.96
Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes. Mol Cell Biochem (2007) 0.96
Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? Apoptosis (2009) 0.95
Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity. Biochem J (2012) 0.91
Advances in phosphopeptide enrichment techniques for phosphoproteomics. Amino Acids (2012) 0.90
Dimethyl fumarate for multiple sclerosis. Expert Opin Investig Drugs (2010) 0.88
Chemical modification of muscle protein in diabetes. Arch Biochem Biophys (2004) 0.87
Tissue distribution of S-(2-succino)cysteine (2SC), a biomarker of mitochondrial stress in obesity and diabetes. Obesity (Silver Spring) (2011) 0.86
Detection and identification of heme c-modified peptides by histidine affinity chromatography, high-performance liquid chromatography-mass spectrometry, and database searching. J Proteome Res (2012) 0.81
Fuel selection in white adipose tissue. Proc Nutr Soc (1995) 0.80
Organic acid profiling in adipocyte differentiation of 3T3-F442A cells: increased production of Krebs cycle acid metabolites. Metabolism (1992) 0.80
Covalent selection of the thiol proteome on activated thiol sepharose: a robust tool for redox proteomics. Talanta (2009) 0.76
Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol (2004) 4.30
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome. J Proteome Res (2005) 4.13
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Advances in proteomics data analysis and display using an accurate mass and time tag approach. Mass Spectrom Rev (2006) 3.80
Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Mol Cell Proteomics (2002) 3.57
DAnTE: a statistical tool for quantitative analysis of -omics data. Bioinformatics (2008) 3.51
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
How much will Herceptin really cost? BMJ (2006) 3.23
Chemically etched open tubular and monolithic emitters for nanoelectrospray ionization mass spectrometry. Anal Chem (2006) 3.22
VIPER: an advanced software package to support high-throughput LC-MS peptide identification. Bioinformatics (2007) 3.15
Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags. Proc Natl Acad Sci U S A (2002) 3.15
Normalization approaches for removing systematic biases associated with mass spectrometry and label-free proteomics. J Proteome Res (2006) 3.10
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00
High-sensitivity ion mobility spectrometry/mass spectrometry using electrodynamic ion funnel interfaces. Anal Chem (2005) 2.99
An IMS-IMS analogue of MS-MS. Anal Chem (2006) 2.68
Whole proteome analysis of post-translational modifications: applications of mass-spectrometry for proteogenomic annotation. Genome Res (2007) 2.67
Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data. BMC Bioinformatics (2009) 2.65
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics (2005) 2.50
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol (2011) 2.45
Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics (2011) 2.44
Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models. Mol Syst Biol (2010) 2.41
Binding MOAD (Mother Of All Databases). Proteins (2005) 2.40
DeconMSn: a software tool for accurate parent ion monoisotopic mass determination for tandem mass spectra. Bioinformatics (2008) 2.38
Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses. Anal Chem (2007) 2.38
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res (2005) 2.35
Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol (2004) 2.31
Statistical characterization of the charge state and residue dependence of low-energy CID peptide dissociation patterns. Anal Chem (2005) 2.29
High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25
High-resolution field asymmetric waveform ion mobility spectrometry using new planar geometry analyzers. Anal Chem (2006) 2.19
Toward plasma proteome profiling with ion mobility-mass spectrometry. J Proteome Res (2006) 2.18
Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications. Mol Cell Proteomics (2006) 2.14
Transport functions dominate the SAR11 metaproteome at low-nutrient extremes in the Sargasso Sea. ISME J (2008) 2.11
Evaluation of multiprotein immunoaffinity subtraction for plasma proteomics and candidate biomarker discovery using mass spectrometry. Mol Cell Proteomics (2006) 2.11
Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy. Mol Cell Proteomics (2008) 2.08
A statistical framework for protein quantitation in bottom-up MS-based proteomics. Bioinformatics (2009) 2.07
Development and evaluation of a micro- and nanoscale proteomic sample preparation method. J Proteome Res (2005) 2.06
The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle. Proc Natl Acad Sci U S A (2008) 2.05
Ionization and transmission efficiency in an electrospray ionization-mass spectrometry interface. J Am Soc Mass Spectrom (2007) 2.03
Fundamentals of traveling wave ion mobility spectrometry. Anal Chem (2008) 2.02
Clinical microfluidics for neutrophil genomics and proteomics. Nat Med (2010) 2.02
Use of artificial neural networks for the accurate prediction of peptide liquid chromatography elution times in proteome analyses. Anal Chem (2003) 2.00
Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome. Anal Chem (2004) 2.00
High-throughput comparative proteome analysis using a quantitative cysteinyl-peptide enrichment technology. Anal Chem (2004) 1.99
Binding MOAD, a high-quality protein-ligand database. Nucleic Acids Res (2007) 1.99
Head-to-head comparison of serum fractionation techniques. J Proteome Res (2007) 1.98
Clustering millions of tandem mass spectra. J Proteome Res (2007) 1.98
Utilizing human blood plasma for proteomic biomarker discovery. J Proteome Res (2005) 1.96
Spectral archives: extending spectral libraries to analyze both identified and unidentified spectra. Nat Methods (2011) 1.95
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics (2005) 1.94
High throughput quantitative analysis of serum proteins using glycopeptide capture and liquid chromatography mass spectrometry. Mol Cell Proteomics (2004) 1.94
Global profiling of Shewanella oneidensis MR-1: expression of hypothetical genes and improved functional annotations. Proc Natl Acad Sci U S A (2005) 1.93
Ion mobility spectrometry-mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures. J Am Soc Mass Spectrom (2007) 1.93
Characterization of the mouse brain proteome using global proteomic analysis complemented with cysteinyl-peptide enrichment. J Proteome Res (2006) 1.93
Proteomics by FTICR mass spectrometry: top down and bottom up. Mass Spectrom Rev (2005) 1.91
Ion funnel trap interface for orthogonal time-of-flight mass spectrometry. Anal Chem (2007) 1.88
High-efficiency nanoscale liquid chromatography coupled on-line with mass spectrometry using nanoelectrospray ionization for proteomics. Anal Chem (2002) 1.88
Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1000-1500 and capabilities in proteomics and metabolomics. Anal Chem (2005) 1.87
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum (2002) 1.85
Precautionary behavior in response to perceived threat of pandemic influenza. Emerg Infect Dis (2007) 1.84
Robust algorithm for alignment of liquid chromatography-mass spectrometry analyses in an accurate mass and time tag data analysis pipeline. Anal Chem (2006) 1.83
Analysis of the Salmonella typhimurium proteome through environmental response toward infectious conditions. Mol Cell Proteomics (2006) 1.82
Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation. Hepatology (2012) 1.82
Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. J Am Soc Nephrol (2005) 1.82
Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface. J Am Soc Mass Spectrom (2006) 1.80
Proteomic analyses using an accurate mass and time tag strategy. Biotechniques (2004) 1.80
PRISM: a data management system for high-throughput proteomics. Proteomics (2006) 1.80
Does trypsin cut before proline? J Proteome Res (2007) 1.79
Enhanced ion utilization efficiency using an electrodynamic ion funnel trap as an injection mechanism for ion mobility spectrometry. Anal Chem (2008) 1.79
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
Skin autofluorescence is a strong predictor of cardiac mortality in diabetes. Diabetes Care (2007) 1.73
Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR. Proc Natl Acad Sci U S A (2002) 1.72
Comparative proteogenomics: combining mass spectrometry and comparative genomics to analyze multiple genomes. Genome Res (2008) 1.68
An automated high performance capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics. J Am Soc Mass Spectrom (2004) 1.68
Home-based medication review in older people: is it cost effective? Pharmacoeconomics (2007) 1.67
Ultrasensitive proteomics using high-efficiency on-line micro-SPE-nanoLC-nanoESI MS and MS/MS. Anal Chem (2004) 1.66
Charge competition and the linear dynamic range of detection in electrospray ionization mass spectrometry. J Am Soc Mass Spectrom (2004) 1.66
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci (2009) 1.65
Two-dimensional gas-phase separations coupled to mass spectrometry for analysis of complex mixtures. Anal Chem (2005) 1.65
Disclosure of genetic tests for health insurance: is it ethical not to? Lancet (2004) 1.65
Assessing quality of life in the elderly: a direct comparison of the EQ-5D and AQoL. Health Econ (2004) 1.64
Proteogenomics: needs and roles to be filled by proteomics in genome annotation. Brief Funct Genomic Proteomic (2008) 1.63
CSAR benchmark exercise of 2010: selection of the protein-ligand complexes. J Chem Inf Model (2011) 1.61
MASIC: a software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC-MS(/MS) features. Comput Biol Chem (2008) 1.61
Is human aging still mysterious enough to be left only to scientists? Bioessays (2002) 1.59
Proteome analyses using accurate mass and elution time peptide tags with capillary LC time-of-flight mass spectrometry. J Am Soc Mass Spectrom (2003) 1.59
Improved peptide elution time prediction for reversed-phase liquid chromatography-MS by incorporating peptide sequence information. Anal Chem (2006) 1.59
In silico method for modelling metabolism and gene product expression at genome scale. Nat Commun (2012) 1.58
Global systems-level analysis of Hfq and SmpB deletion mutants in Salmonella: implications for virulence and global protein translation. PLoS One (2009) 1.58
Paying for statins. BMJ (2004) 1.57
Application of peptide LC retention time information in a discriminant function for peptide identification by tandem mass spectrometry. J Proteome Res (2004) 1.56
Proteomic analysis of Salmonella enterica serovar typhimurium isolated from RAW 264.7 macrophages: identification of a novel protein that contributes to the replication of serovar typhimurium inside macrophages. J Biol Chem (2006) 1.55
Establishing the proteome of normal human cerebrospinal fluid. PLoS One (2010) 1.53
Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum. Proc Natl Acad Sci U S A (2012) 1.52
The ion funnel: theory, implementations, and applications. Mass Spectrom Rev (2010) 1.52