| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Safety aspects of iodinated contrast media related to their physicochemical properties: a pharmacoepidemiology study in two Tuscany hospitals.
|
Eur J Clin Pharmacol
|
2008
|
1.46
|
|
2
|
Calcium channel antagonists discovered by a multidisciplinary approach.
|
J Med Chem
|
2006
|
0.85
|
|
3
|
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
|
J Med Chem
|
2007
|
0.84
|
|
4
|
Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold.
|
Br J Pharmacol
|
2013
|
0.83
|
|
5
|
1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists.
|
J Med Chem
|
2012
|
0.81
|
|
6
|
The direct stimulation of Gi proteins by neuropeptide Y (NPY) in the rat left ventricle.
|
Biochem Pharmacol
|
2002
|
0.80
|
|
7
|
Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity.
|
Arch Pharm (Weinheim)
|
2009
|
0.79
|
|
8
|
Synthesis and biological evaluation of chiral alpha-aminoanilides with central antinociceptive activity.
|
J Med Chem
|
2007
|
0.78
|
|
9
|
Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity.
|
ChemMedChem
|
2010
|
0.77
|
|
10
|
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.
|
Bioorg Med Chem Lett
|
2013
|
0.76
|
|
11
|
Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates.
|
Bioorg Med Chem
|
2003
|
0.75
|
|
12
|
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
|
J Med Chem
|
2006
|
0.75
|
|
13
|
Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.
|
J Med Chem
|
2004
|
0.75
|
|
14
|
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives.
|
Biochem Pharmacol
|
2005
|
0.75
|
|
15
|
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.
|
Bioorg Med Chem
|
2008
|
0.75
|
|
16
|
Does aspirin attenuate the beneficial effect of ACE inhibitors in elderly people with heart failure?
|
Drugs Aging
|
2005
|
0.75
|
|
17
|
Muscarine-like compounds derived from a pyrolysis product of cellulose.
|
Org Biomol Chem
|
2015
|
0.75
|
|
18
|
Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity.
|
Farmaco
|
2004
|
0.75
|
|
19
|
The conformational and property space of acetylcholine bound to muscarinic receptors: an entropy component accounts for the subtype selectivity of acetylcholine.
|
Arch Biochem Biophys
|
2007
|
0.75
|
|
20
|
Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).
|
J Med Chem
|
2014
|
0.75
|
|
21
|
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
|
J Med Chem
|
2010
|
0.75
|
|
22
|
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
|
J Med Chem
|
2008
|
0.75
|
|
23
|
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.
|
Bioorg Med Chem
|
2009
|
0.75
|
|
24
|
1,2,4-Benzothiadiazine-1,1-dioxide derivatives as ionotropic glutamate receptor ligands: synthesis and structure-activity relationships.
|
Arch Pharm (Weinheim)
|
2014
|
0.75
|
|
25
|
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.
|
Bioorg Med Chem Lett
|
2007
|
0.75
|