| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.
|
J Pharmacol Exp Ther
|
1999
|
2.01
|
|
2
|
Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression.
|
Exp Lung Res
|
1996
|
1.77
|
|
3
|
Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters.
|
Thorax
|
1999
|
1.62
|
|
4
|
Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters.
|
Am J Pathol
|
1983
|
1.50
|
|
5
|
Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters.
|
J Lab Clin Med
|
1995
|
1.39
|
|
6
|
Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.
|
J Pharmacol Exp Ther
|
1999
|
1.26
|
|
7
|
Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level.
|
Am J Physiol
|
1999
|
1.21
|
|
8
|
Effect of murine gamma interferon on the cellular responses to bleomycin in mice.
|
Exp Lung Res
|
1988
|
1.12
|
|
9
|
Effect of acute lung injury on angiotensin converting enzyme in serum, lung lavage, and effusate.
|
Am Rev Respir Dis
|
1980
|
1.07
|
|
10
|
Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model.
|
Exp Lung Res
|
1998
|
1.04
|
|
11
|
Effects of three anti-TNF-alpha drugs: etanercept, infliximab and pirfenidone on release of TNF-alpha in medium and TNF-alpha associated with the cell in vitro.
|
Int Immunopharmacol
|
2008
|
1.00
|
|
12
|
Anti-inflammatory effect of pirfenidone in the bleomycin-hamster model of lung inflammation.
|
Inflammation
|
2000
|
1.00
|
|
13
|
The response of the rat tracheal epithelium to ozone exposure. Injury, adaptation, and repair.
|
Am J Pathol
|
1988
|
0.98
|
|
14
|
Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice.
|
J Pharmacol Exp Ther
|
2000
|
0.97
|
|
15
|
Iron(II) is a modulator of ryanodine-sensitive calcium channels of cardiac muscle sarcoplasmic reticulum.
|
Toxicol Appl Pharmacol
|
1995
|
0.96
|
|
16
|
Effect of paraquat on serum angiotensin converting enzyme.
|
Am Rev Respir Dis
|
1980
|
0.94
|
|
17
|
Differential expression of alpha E beta 7 integrins on bronchoalveolar lavage T lymphocyte subsets: regulation by alpha 4 beta 1-integrin crosslinking and TGF-beta.
|
Am J Respir Cell Mol Biol
|
1996
|
0.93
|
|
18
|
Antipyretic activity of Nelumbo nucifera rhizome extract.
|
Indian J Exp Biol
|
1996
|
0.92
|
|
19
|
Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters.
|
Toxicol Appl Pharmacol
|
1983
|
0.90
|
|
20
|
Biochemical and structural alterations of hamster lungs in response to intratracheal administration of bleomycin.
|
Exp Mol Pathol
|
1980
|
0.90
|
|
21
|
Changes in plasma concentrations of prostaglandins and plasma angiotensin-converting enzyme during bleomycin-induced lung fibrosis in hamsters.
|
Am Rev Respir Dis
|
1983
|
0.89
|
|
22
|
Evaluation of antifibrotic drugs in bleomycin-induced pulmonary fibrosis in hamsters.
|
J Pharmacol Exp Ther
|
1980
|
0.89
|
|
23
|
Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin.
|
Nitric Oxide
|
2000
|
0.88
|
|
24
|
Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice.
|
Biochem Med Metab Biol
|
1986
|
0.88
|
|
25
|
Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin.
|
Biochem Pharmacol
|
1991
|
0.88
|
|
26
|
Characteristic features of actinomycin D-induced paw inflammation of the rat.
|
Exp Mol Pathol
|
1975
|
0.87
|
|
27
|
Binding of radioactivity from (14C)thiourea to rat lung protein.
|
Drug Metab Dispos
|
1976
|
0.87
|
|
28
|
Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice.
|
Biochem Pharmacol
|
2000
|
0.87
|
|
29
|
Role of leukotriene B4 in the pathogenesis of Klebsiella pneumoniae-induced bovine mastitis.
|
Am J Vet Res
|
1989
|
0.84
|
|
30
|
Niacin attenuates bleomycin-induced lung fibrosis in the hamster.
|
J Biochem Toxicol
|
1990
|
0.84
|
|
31
|
Effects of a calmodulin inhibitor on bleomycin-induced lung inflammation in hamsters. Biochemical, morphometric, and bronchoalveolar lavage data.
|
Am J Pathol
|
1986
|
0.84
|
|
32
|
Mechanism of antifibrotic effect of taurine and niacin in the multidose bleomycin-hamster model of lung fibrosis: inhibition of lysyl oxidase and collagenase.
|
J Biochem Toxicol
|
1995
|
0.84
|
|
33
|
Increases in lung prolyl hydroxylase and superoxide dismutase activities during bleomycin-induced lung fibrosis in hamsters.
|
Exp Mol Pathol
|
1983
|
0.84
|
|
34
|
Analysis of bronchoalveolar lavage fluid from bleomycin-induced pulmonary fibrosis in hamsters.
|
Toxicol Pathol
|
1986
|
0.83
|
|
35
|
Time and dose-response study of the effects of vanadate on rats: morphological and biochemical changes in organs.
|
J Environ Pathol Toxicol Oncol
|
1989
|
0.83
|
|
36
|
Effect of acute and chronic paraquat on rat lung collagen content.
|
Res Commun Chem Pathol Pharmacol
|
1978
|
0.82
|
|
37
|
Repeated episodes of C5a-induced neutrophil influx do not result in pulmonary fibrosis.
|
Inflammation
|
1991
|
0.82
|
|
38
|
The effect of alpha-difluoromethylornithine on the development of bleomycin-induced pulmonary fibrosis in hamsters.
|
Am J Pathol
|
1982
|
0.82
|
|
39
|
Pulmonary structural and extracellular matrix alterations in Fischer 344 rats following subchronic phosgene exposure.
|
Fundam Appl Toxicol
|
1997
|
0.82
|
|
40
|
Pharmacokinetics, covalent binding and subcellular distribution of [3H]doxorubicin after intravenous administration in the mouse.
|
J Pharmacol Exp Ther
|
1981
|
0.81
|
|
41
|
Etiology of sarcoplasmic reticulum calcium release channel lesions in doxorubicin-induced cardiomyopathy.
|
Toxicology
|
1992
|
0.81
|
|
42
|
Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin.
|
Lab Invest
|
1992
|
0.81
|
|
43
|
Pharmacokinetics, subcellular distribution, and covalent binding of [3H]bleomycin in hamsters after intratracheal administration.
|
Exp Mol Pathol
|
1986
|
0.81
|
|
44
|
Effects of intratracheal administration of bleomycin or saline in pair-fed and control-fed hamsters on daily food intake and on plasma levels of glucose, cortisol, and insulin, and lung levels of calmodulin, calcium, and collagen.
|
Exp Mol Pathol
|
1985
|
0.81
|
|
45
|
Effect of bovine respiratory syncytial virus infection on hypersensitivity to inhaled Micropolyspora faeni.
|
Int Arch Allergy Immunol
|
1994
|
0.81
|
|
46
|
Integrin alpha E beta 7 expression on BAL CD4+, CD8+, and gamma delta T-cells in bleomycin-induced lung fibrosis in mouse.
|
Eur Respir J
|
1996
|
0.81
|
|
47
|
Acute ozone exposure increases plasma prostaglandin F2 alpha in ozone-sensitive human subjects.
|
Am Rev Respir Dis
|
1989
|
0.81
|
|
48
|
Effects of acute paraquat toxicity on circulating levels of arachidonic acid, PGF2 alpha and PGE2 in the beagle.
|
Prostaglandins Med
|
1981
|
0.81
|
|
49
|
Role of prostaglandins, histamine, and serotonin in the pathophysiology induced by Pasteurella hemolytica endotoxin in sheep.
|
Circ Shock
|
1984
|
0.80
|
|
50
|
Attenuation of amiodarone-induced lung fibrosis and phospholipidosis in hamsters by taurine and/or niacin treatment.
|
J Pharmacol Exp Ther
|
1992
|
0.80
|
|
51
|
Interaction of thiourea with rat lung protein.
|
Toxicology
|
1990
|
0.80
|
|
52
|
Development of a bleomycin hamster model of subchronic lung fibrosis.
|
Pathology
|
1992
|
0.80
|
|
53
|
Repeated exposures to enzyme-generated oxidants cause alveolitis, epithelial hyperplasia, and fibrosis in hamsters.
|
Am J Pathol
|
1991
|
0.80
|
|
54
|
gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters.
|
Lipids
|
1997
|
0.80
|
|
55
|
Polyinosinic-polycytidylic acid, an interferon inducer, ameliorates bleomycin-induced lung fibrosis in mice.
|
Exp Lung Res
|
1990
|
0.80
|
|
56
|
Poly(ADP-ribose) synthetase activity during bleomycin-induced lung fibrosis in hamsters.
|
Exp Mol Pathol
|
1985
|
0.80
|
|
57
|
Viral-bacterial pneumonia in calves: effects on plasma eicosanoids and long chain fatty acids.
|
Int J Tissue React
|
1987
|
0.80
|
|
58
|
Effects of chronic administration of doxorubicin on myocardial beta-adrenergic receptors.
|
Life Sci
|
1986
|
0.80
|
|
59
|
Prostaglandin and thromboxane concentrations in plasma and lung lavage fluids during sequential infection of vaccinated and nonvaccinated calves with bovine respiratory syncytial virus.
|
Am J Vet Res
|
1989
|
0.79
|
|
60
|
Effects of lung toxins on PGF2 alpha and PGE2 levels in plasma and combined pleural effusion and lung lavage of rats.
|
Adv Prostaglandin Thromboxane Res
|
1980
|
0.79
|
|
61
|
Ozone effects on mechanics and arachidonic acid metabolite concentrations in isolated rat lungs.
|
Environ Res
|
1994
|
0.79
|
|
62
|
A pharmacodynamic study of (14C)thiourea toxicity in mature, immature, tolerant, and nontolerant rats.
|
Toxicol Appl Pharmacol
|
1976
|
0.79
|
|
63
|
Effect of paraquat on plasma enzymes, insulin, glucose, and liver glycogen in the rat.
|
Environ Res
|
1979
|
0.79
|
|
64
|
Effects of intratracheal administration of bleomycin on prostaglandins and thromboxane-B2 and collagen levels of the lung in hamsters.
|
Exp Lung Res
|
1985
|
0.79
|
|
65
|
Studies on antitussive activity of Drymaria cordata Willd. (Caryophyllaceae).
|
J Ethnopharmacol
|
1997
|
0.79
|
|
66
|
Effects of recombinant human interleukin-2 and excipient infusion on plasma levels of prostaglandins and thromboxane B2 in sheep.
|
Lymphokine Cytokine Res
|
1991
|
0.79
|
|
67
|
Dose-related effects of Ampligen (poly(I).poly(C12U)), a mismatched double-stranded RNA, in a bleomycin-mouse model of pulmonary fibrosis.
|
Exp Lung Res
|
1996
|
0.79
|
|
68
|
Tissue distribution and binding of radioactivity from 14C-thiourea in the rat.
|
Proc West Pharmacol Soc
|
1975
|
0.79
|
|
69
|
Epithelial injury, inflammation, and repair in the hamster lung following intratracheal instillation of enzyme-generated oxidants.
|
Exp Lung Res
|
1991
|
0.79
|
|
70
|
Regulation of transforming growth factor-beta1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis.
|
Am J Respir Cell Mol Biol
|
1998
|
0.79
|
|
71
|
Dose and regimen effects of poly ICLC, an interferon inducer, in a multi-dose bleomycin model of interstitial pulmonary fibrosis.
|
Pharmacol Toxicol
|
1994
|
0.78
|
|
72
|
14C-Thiourea binding in the rat lung.
|
Res Commun Chem Pathol Pharmacol
|
1979
|
0.78
|
|
73
|
Tissue distribution and binding of radioactivity from 14C-thiourea in the rat.
|
Drug Metab Dispos
|
1975
|
0.78
|
|
74
|
Effects of dibutyrylcyclic adenosine monophosphate on bleomycin-induced lung toxicity in hamsters.
|
J Appl Toxicol
|
1992
|
0.78
|
|
75
|
Sulfur-containing compounds and tolerance in the prevention of certain metabolic effects of phenylthiourea.
|
Toxicol Appl Pharmacol
|
1970
|
0.78
|
|
76
|
Ozone-induced pulmonary functional, pathological, and biochemical changes in normal and vitamin C-deficient guinea pigs.
|
Fundam Appl Toxicol
|
1995
|
0.78
|
|
77
|
Effects in vitro and in vivo of thioureas on acetylcholine esterase activity of rat tissues.
|
Biochem Pharmacol
|
1977
|
0.78
|
|
78
|
Effects of thiourea on pulmonary edema, pleural and peritoneal effusions and toxicity in rats pretreated with actinomycin D.
|
Toxicology
|
1974
|
0.78
|
|
79
|
Pharmacokinetics of orally administered pirfenidone in male and female beagles.
|
J Vet Pharmacol Ther
|
2004
|
0.78
|
|
80
|
Effects of chronic administration of doxorubicin on myocardial creatine phosphokinase and antioxidant defenses and levels of lipid peroxidation in tissues and plasma of rats.
|
J Biochem Toxicol
|
1989
|
0.78
|
|
81
|
Effects of chronic administration of doxorubicin on heart phospholipase A2 activity and in vitro synthesis and degradation of prostaglandins in rats.
|
Prostaglandins Leukot Med
|
1987
|
0.77
|
|
82
|
Effects of pretreatment with anti-inflammatory drugs on ozone-induced lung damage in rats.
|
Proc Soc Exp Biol Med
|
1975
|
0.77
|
|
83
|
Up-regulation of platelet-activating factor receptors in lung and alveolar macrophages in the bleomycin-hamster model of pulmonary fibrosis.
|
J Pharmacol Exp Ther
|
1997
|
0.77
|
|
84
|
The effects of paraquat and superoxide dismutase on pulmonary vascular permeability and edema in mice.
|
Arch Environ Health
|
1981
|
0.77
|
|
85
|
Effects of smooth and rough Pasteurella haemolytica lipopolysaccharides on plasma cyclic-nucleotides and free fatty acids in calves.
|
Vet Microbiol
|
1987
|
0.77
|
|
86
|
Characteristics and effect of antiinflammatory drugs on adriamycin-induced inflammation in the mouse paw.
|
Inflammation
|
1980
|
0.77
|
|
87
|
Time and dose-response study of the effects of vanadate in rats: changes in blood cells, serum enzymes, protein, cholesterol, glucose, calcium, and inorganic phosphate.
|
J Environ Pathol Toxicol Oncol
|
1991
|
0.77
|
|
88
|
Role of prostaglandins in pathogenesis of bovine mastitis induced by Escherichia coli endotoxin.
|
Am J Vet Res
|
1984
|
0.77
|
|
89
|
Characterization of a phospholipase A2 in hamster lung and in vitro and in vivo effects of bleomycin on this enzyme.
|
Prostaglandins Leukot Essent Fatty Acids
|
1989
|
0.77
|
|
90
|
Fate of superoxide dismutase in mice following oral route of administration.
|
Med Biol
|
1984
|
0.77
|
|
91
|
The effect of paraquat on guanylate cyclase activity in relation to morphological changes of guinea pig lungs.
|
Lung
|
1980
|
0.77
|
|
92
|
Comparative effects of smooth and rough Pasteurella hemolytica lipopolysaccharides on arachidonic acid, eicosanoids, serotonin, and histamine in calves.
|
Circ Shock
|
1986
|
0.77
|
|
93
|
Role of eicosanoids, histamine, and serotonin in the pathogenesis of Klebsiella pneumoniae-induced bovine mastitis.
|
Am J Vet Res
|
1987
|
0.77
|
|
94
|
Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis.
|
J Pharmacol Exp Ther
|
1996
|
0.77
|
|
95
|
Pharmacokinetics of [14C]-paraquat and associated biochemical and pathologic changes in Beagle dogs following intravenous administration.
|
Fundam Appl Toxicol
|
1983
|
0.77
|
|
96
|
Non-enzymatic covalent binding of radioactivity from [14C]thiourea to rat lung protein.
|
Toxicol Lett
|
1990
|
0.76
|
|
97
|
Effects of three cysteine pro-drugs on bleomycin-induced lung fibrosis in hamsters.
|
Pathology
|
1990
|
0.76
|
|
98
|
Biochemical and haematological changes following prolonged halothane anaesthesia in horses.
|
Res Vet Sci
|
1993
|
0.76
|
|
99
|
Biochemical mechanisms for the attenuation of bleomycin-induced lung fibrosis by treatment with niacin in hamsters: the role of NAD and ATP.
|
Exp Lung Res
|
1994
|
0.76
|
|
100
|
Effect of chronic administration of doxorubicin on cardiac adenylate cyclase activity in mice.
|
Biochem Biophys Res Commun
|
1986
|
0.76
|
|
101
|
The in vitro synthesis and degradation of prostaglandins during the development of bleomycin-induced pulmonary fibrosis in hamsters.
|
Prostaglandins Leukot Med
|
1983
|
0.76
|
|
102
|
Antirheumatic effect of pirfenidone in a double blind clinical pilot trial in humans.
|
Res Commun Mol Pathol Pharmacol
|
2004
|
0.76
|
|
103
|
Effects of taurine on bleomycin-induced lung fibrosis in hamsters.
|
Proc Soc Exp Biol Med
|
1989
|
0.76
|
|
104
|
Effects of paraquat on plasma glucose, cortisol, catecholamines, and insulin in the beagle.
|
Environ Res
|
1983
|
0.76
|
|
105
|
Structural and biochemical changes in lungs of 3-methylindole-treated rats.
|
Am J Pathol
|
1993
|
0.75
|
|
106
|
Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis.
|
J Biochem Toxicol
|
1994
|
0.75
|
|
107
|
Effects of an interferon inducer bropirimine on bleomycin-induced lung fibrosis in hamsters.
|
Pharmacol Toxicol
|
1992
|
0.75
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108
|
Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: histamine, prostaglandin D2, prostaglandin E2 and leukotriene C4.
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Int J Parasitol
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1993
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0.75
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109
|
Effects of intravenous infusion of doxorubicin on blood chemistry, blood pressure and heart rate in rabbits.
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J Appl Toxicol
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1985
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0.75
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110
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Oral toxicity of azinphosmethyl in horses.
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Am J Vet Res
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1974
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0.75
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111
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The role of renal aromatic N-deacetylase in selective toxicity of avicide 3-chloro-p-toluidine in birds.
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Biochim Biophys Acta
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1972
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0.75
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112
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In vivo hemolytic potency and binding of chlorpromazine to plasma protein and erythrocytes of rat and dog (38579).
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Proc Soc Exp Biol Med
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1975
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0.75
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113
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Effects of an acutely toxic dose of the avicide 3-chloro-p-toluidine in chickens.
|
Toxicol Appl Pharmacol
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1972
|
0.75
|
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114
|
Potentiating effects of chlorpromazine on the paralysis and toxicity induced by guaiacal glyceryl ether in rats.
|
Toxicol Appl Pharmacol
|
1972
|
0.75
|
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115
|
The effect of bleomycin on the uptake and incorporation of [14C]choline into phospholipids in hamster lung tissue slices.
|
Lipids
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1990
|
0.75
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116
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Effects of nalorphine and morphine on the development of comb size, body weight and testes in cockrels.
|
Life Sci
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1968
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0.75
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117
|
Influence of phenoxybenzamine on gastric evacuation in rats.
|
Life Sci I
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1970
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0.75
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118
|
Histopathological features and biochemical mechanism of 2-chloro-4-acetotoluidine toxicity in starling.
|
Exp Mol Pathol
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1978
|
0.75
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119
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Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves.
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Am J Vet Res
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1984
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0.75
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120
|
A new method for analysis of phenylthiourea in biological fluids.
|
Anal Biochem
|
1971
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0.75
|
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121
|
Effects of pulmonary irritants on DNA, ATPase activity, and histamine on rat lung.
|
Proc Soc Exp Biol Med
|
1974
|
0.75
|
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122
|
Effects of bleomycin on 14C-proline uptake, its incorporation into proteins and hydroxylation in collagenous proteins of hamster lung slices.
|
J Appl Toxicol
|
1985
|
0.75
|
|
123
|
Effect of dactinomycin and ethionine on thiourea and phenylthiourea tolerance.
|
Arch Environ Health
|
1969
|
0.75
|
|
124
|
The effects of heparin pretreatment on plasma histamine following thermal injury in rats and cats.
|
Circ Shock
|
1978
|
0.75
|
|
125
|
Effects of niacin on bleomycin-induced increases in myeloperoxidase, prolyl hydroxylase, and superoxide dismutase activities and collagen accumulation in the lungs of hamsters.
|
J Biochem Toxicol
|
1992
|
0.75
|
|
126
|
Hexachlorobenzene II. Effects on growing lambs of prolonged low-level oral exposure to hexachlorobenzene (HCB).
|
J Environ Pathol Toxicol
|
1979
|
0.75
|
|
127
|
Temperature dependent aqueos solubility of actinomycin D.
|
Experientia
|
1975
|
0.75
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|
128
|
Epithelial injury is a critical factor in the development of pulmonary fibrosis following multiple episodes of inflammation.
|
Chest
|
1991
|
0.75
|
|
129
|
The pharmacological action and O-demethylation of glyceryl guaiacolate ether in male and female rats.
|
Toxicol Appl Pharmacol
|
1973
|
0.75
|
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130
|
Effect of thiourea on pulmonary vascular leakage in rats of different ages.
|
Proc West Pharmacol Soc
|
1975
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0.75
|
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131
|
Development of a dual isotopes techniques and two-stage column chromatography to characterize the prostaglandin F2alpha, E2 and Thromboxane B2 formed by the guinea pig lung.
|
J Pharmacol Methods
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1980
|
0.75
|
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132
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Stimulatory effects of phenobarbital pretreatment on the metabolism of glyceryl guaiacolate ether.
|
Arch Int Pharmacodyn Ther
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1971
|
0.75
|
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133
|
The effect of thermal burns on blood and plasma histamine levels in the rat and the cat.
|
Proc West Pharmacol Soc
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1975
|
0.75
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