Published in Small GTPases on October 22, 2013
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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
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K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22
A comprehensive survey of Ras mutations in cancer. Cancer Res (2012) 3.67
p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev (2006) 3.66
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Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene (2000) 1.76
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Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proc Natl Acad Sci U S A (2009) 1.67
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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest (2007) 1.64
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev (2006) 1.60
Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia. Dev Cell (2007) 1.54
Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res (2004) 1.50
Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep (2005) 1.43
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest (2008) 1.38
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Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene (2002) 1.30
Inducible activation of Ras and Raf in adult epidermis. Cancer Res (2003) 1.29
Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle (2007) 1.13
Ras signaling is essential for skin development. Oncogene (2013) 0.98
Genetically engineered mouse models for skin research: taking the next step. J Dermatol Sci (2008) 0.94
Epidermal development in mammals: key regulators, signals from beneath, and stem cells. Int J Mol Sci (2013) 0.90
Non-melanoma skin cancer in mouse and man. Arch Toxicol (2012) 0.88
Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63. J Skin Cancer (2013) 0.80