Published in Curr Drug Metab on November 01, 2013
Experimental models of hepatotoxicity related to acute liver failure. Toxicol Appl Pharmacol (2015) 0.88
Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. Prog Lipid Res (2015) 0.84
Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells. Cell Biol Toxicol (2015) 0.78
CYP3A4 inhibition by Psoralea corylifolia and its major components in human recombinant enzyme, differentiated human hepatoma HuH-7 and HepaRG cells. Toxicol Rep (2015) 0.75
Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance. Hum Cell (2017) 0.75
Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J Gastroenterol (2006) 1.37
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant (2012) 1.31
Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved. FASEB J (2002) 1.30
Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drug Metab (2007) 1.17
ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses. Drug Metab Dispos (2008) 1.13
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opin Drug Metab Toxicol (2006) 1.09
Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes. Drug Metab Dispos (2004) 1.08
Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells. J Biol Chem (2006) 1.04
Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug Metab Dispos (2006) 1.00
Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Chem Biol Interact (2010) 1.00
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1. Mol Pharmacol (2006) 0.98
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease. Biochim Biophys Acta (2013) 0.96
Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha. Curr Drug Metab (2009) 0.95
Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein). Mol Pharmacol (2005) 0.93
Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes. Toxicol Sci (2002) 0.90
Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. Arch Biochem Biophys (2004) 0.90
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver. PLoS One (2012) 0.90
A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Arch Toxicol (2014) 0.89
Cytochrome p450 and steatosis. Curr Drug Metab (2009) 0.89
Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates. Curr Drug Metab (2012) 0.89
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved. Arch Toxicol (2013) 0.88
Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem Pharmacol (2003) 0.88
High-content screening technology for studying drug-induced hepatotoxicity in cell models. Arch Toxicol (2015) 0.87
Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies. Anal Bioanal Chem (2010) 0.85
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay. J Biomol Screen (2011) 0.85
Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. Pharmacogenomics (2006) 0.83
Cytometric analysis for drug-induced steatosis in HepG2 cells. Chem Biol Interact (2009) 0.82
Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. Biochem Biophys Res Commun (2006) 0.82
Neonatal livers: a source for the isolation of good-performing hepatocytes for cell transplantation. Cell Transplant (2013) 0.82
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. Toxicol Sci (2012) 0.82
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment. Toxicol In Vitro (2011) 0.82
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors. Toxicol In Vitro (2012) 0.81
Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. Mol Nutr Food Res (2015) 0.81
Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes. Toxicol In Vitro (2003) 0.80
Establishment and characterization of immortal hepatocytes derived from various transgenic mouse lines. Biochem Biophys Res Commun (2002) 0.80
Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes. Pharmacol Rep (2013) 0.79
Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells. Cancer Lett (2004) 0.79
Role of K+ and Ca2+ fluxes in the cerebroarterial vasoactive effects of sildenafil. Eur J Pharmacol (2007) 0.78
Liver grafts preserved in Celsior solution as source of hepatocytes for drug metabolism studies: comparison with surgical liver biopsies. Drug Metab Dispos (2004) 0.77
Influence of platelet lysate on the recovery and metabolic performance of cryopreserved human hepatocytes upon thawing. Transplantation (2011) 0.77
Can hepatoma cell lines be redifferentiated to be used in drug metabolism studies? Altern Lab Anim (2004) 0.77
Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells. J Pharm Pharmacol (2013) 0.76
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys (2005) 0.76
[Hepatic cell transplantation. Technical and methodological aspects]. Cir Esp (2010) 0.76
Fluorescence-based screening of cytochrome P450 activities in intact cells. Methods Mol Biol (2013) 0.75
[Alternative sources of hepatocytes for cell therapy]. Gastroenterol Hepatol (2006) 0.75
Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors. Methods Mol Biol (2015) 0.75