Alexander Koch

Author PubWeight™ 59.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9. Cardiovasc Res 2008 1.80
2 Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury. Crit Care Med 2010 1.73
3 The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury. Crit Care Med 2007 1.61
4 Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor necrosis factor-alpha. Crit Care Med 2004 1.55
5 Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med 2009 1.54
6 Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion. Crit Care Med 2010 1.45
7 Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget 2013 1.44
8 Iron Parameters Determine the Prognosis of Critically Ill Patients. Crit Care Med 2016 1.43
9 Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review. Intensive Care Med 2012 1.41
10 Deep proteome coverage based on ribosome profiling aids mass spectrometry-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation events. Mol Cell Proteomics 2013 1.33
11 Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis. PLoS One 2013 1.18
12 U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis. Exp Mol Med 2013 1.17
13 miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. J Hepatol 2012 1.13
14 Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care 2010 1.08
15 Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. PLoS One 2009 1.08
16 Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A 2006 1.08
17 Clinical chemistry reference database for Wistar rats and C57/BL6 mice. Biol Chem 2007 1.08
18 Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. PLoS One 2012 1.08
19 Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 2012 1.07
20 High C5a levels are associated with increased mortality in sepsis patients--no enhancing effect by actin-free Gc-globulin. Clin Biochem 2008 1.01
21 Semi-automated measurement of hyperdense, hypodense and heterogeneous hepatic metastasis on standard MDCT slices. Comparison of semi-automated and manual measurement of RECIST and WHO criteria. Eur Radiol 2008 1.01
22 CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo. Respir Res 2007 1.00
23 Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. Eur J Pharmacol 2009 0.99
24 Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis. Liver Int 2011 0.99
25 Electroanatomic reconstruction of the left atrium, pulmonary veins, and esophagus compared with the "true anatomy" on multislice computed tomography in patients undergoing catheter ablation of atrial fibrillation. Heart Rhythm 2006 0.98
26 Compliance with hand hygiene on surgical, medical, and neurologic intensive care units: direct observation versus calculated disinfectant usage. Am J Infect Control 2009 0.98
27 Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun 2011 0.97
28 Levels of circulating miR-133a are elevated in sepsis and predict mortality in critically ill patients. Crit Care Med 2014 0.97
29 E-cadherin is a ligand for integrin alpha2beta1. Matrix Biol 2002 0.96
30 Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases. Liver Int 2014 0.96
31 Effects of cardiac surgery on hemostasis. Transfus Med Rev 2006 0.93
32 Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. Biochem J 2012 0.92
33 Longitudinal monocyte human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis. Liver Int 2008 0.91
34 Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. Biochim Biophys Acta 2009 0.90
35 The minimal essential unit for cadherin-mediated intercellular adhesion comprises extracellular domains 1 and 2. J Biol Chem 2004 0.90
36 Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem Pharmacol 2006 0.89
37 Toll-like receptor 9 expression in murine and human adrenal glands and possible implications during inflammation. J Clin Endocrinol Metab 2007 0.89
38 Insulin-like growth factor binding proteins-2 and -4 enhance the migration of human CD34-/CD133+ hematopoietic stem and progenitor cells. Int J Mol Med 2010 0.88
39 Association of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing? Immun Ageing 2013 0.87
40 Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim Biophys Acta 2008 0.87
41 Effect of coronary collaterals on long-term prognosis in patients undergoing primary angioplasty for acute ST-elevation myocardial infarction. Am J Cardiol 2010 0.86
42 FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke. PLoS One 2013 0.86
43 The effects of the fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of myocardial ischemia-reperfusion. Shock 2007 0.85
44 PPARalpha agonists up-regulate organic cation transporters in rat liver cells. Biochem Biophys Res Commun 2006 0.85
45 Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity. Clin Biochem 2011 0.84
46 Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochim Biophys Acta 2013 0.83
47 Systemic endotoxin activity correlates with clot formation: an observational study in patients with early systemic inflammation and sepsis. Crit Care 2013 0.82
48 YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo. J Immunol 2013 0.82
49 Simultaneous placement of multiple central lines increases central line-associated bloodstream infection rates. Am J Infect Control 2012 0.82
50 Profuse rectal bleeding of no visible cause. Lancet 2007 0.81
51 Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients. J Crit Care 2013 0.81
52 Why high suPAR is not super--diagnostic, prognostic and potential pathogenic properties of a novel biomarker in the ICU. Crit Care 2011 0.80
53 Accurate and continuous measurement of oxygen deficit during haemorrhage in pigs. Resuscitation 2008 0.79
54 A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs. Resuscitation 2008 0.79
55 Predictive factors for survival and recurrence rate in patients with node-negative gastric cancer--a European single-centre experience. Langenbecks Arch Surg 2014 0.79
56 Tris(pyrazolyl)methanides of the alkaline earth metals: influence of the substitution pattern on stability and degradation. Inorg Chem 2015 0.76
57 Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock. Crit Care Med 2009 0.75
58 Superimposed high-frequency jet ventilation combined with continuous positive airway pressure/assisted spontaneous breathing improves oxygenation in patients with H1N1-associated ARDS. Ann Intensive Care 2012 0.75
59 IL-6 may modulate the skeletal response to glucocorticoids during exacerbations of inflammatory bowel disease. Calcif Tissue Int 2010 0.75
60 The authors reply. Crit Care Med 2016 0.75
61 Authors' response: impact of renal replacement therapy on osteopontin levels in critically ill patients. Crit Care 2015 0.75
62 The psychophysical assessment of odor valence: does an anchor stimulus influence the hedonic evaluation of odors? Chem Senses 2013 0.75
63 The authors reply. Crit Care Med 2016 0.75
64 Lessons from a patient with an unusual hepatic overlap syndrome. Nat Clin Pract Gastroenterol Hepatol 2007 0.75
65 Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1. J Surg Res 2008 0.75
66 Strong intramolecular calcium-π interactions with aryl substituents--requirements and limitations. Dalton Trans 2014 0.75
67 Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. Biol Chem 2015 0.75
68 Synthesis and Exfoliation of a New Layered Mesoporous Zr-MOF Comprising Hexa- and Dodecanuclear Clusters as well as a Small Organic Linker Molecule. J Am Chem Soc 2020 0.75
69 [Consciousness disorders from toxicological view]. Dtsch Med Wochenschr 2016 0.75