Published in J Steroid Biochem Mol Biol on October 28, 2013
Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity. Exp Dermatol (2014) 1.52
RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB J (2014) 1.39
Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol (2014) 1.31
Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland. Sci Rep (2015) 1.23
Local melatoninergic system as the protector of skin integrity. Int J Mol Sci (2014) 1.15
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. Mol Cell Endocrinol (2013) 1.14
On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids (2015) 1.01
Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J Steroid Biochem Mol Biol (2015) 1.00
Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity. Anticancer Res (2014) 0.95
Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses. Anticancer Res (2014) 0.93
Vitamin d and its relationship with obesity and muscle. Int J Endocrinol (2014) 0.92
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies. Int J Mol Sci (2014) 0.88
Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts. Exp Dermatol (2016) 0.88
Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism. J Invest Dermatol (2015) 0.86
Vitamin D and skin cancer. Photochem Photobiol (2014) 0.85
Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes. J Steroid Biochem Mol Biol (2014) 0.82
Design, synthesis, and biological evaluation of stable colchicine binding site tubulin inhibitors as potential anticancer agents. J Med Chem (2014) 0.82
Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1. J Steroid Biochem Mol Biol (2015) 0.81
Primary human osteoblasts in response to 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3. PLoS One (2014) 0.80
Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives. J Med Chem (2015) 0.80
Total synthesis of biologically active 20S-hydroxyvitamin D3. Steroids (2015) 0.80
Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas. Oncol Rep (2014) 0.80
Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Int J Oncol (2015) 0.79
Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation. Int J Mol Sci (2015) 0.79
Expression of Vitamin D Receptor (VDR) Positively Correlates with Survival of Urothelial Bladder Cancer Patients. Int J Mol Sci (2015) 0.79
Lumisterol is metabolized by CYP11A1: discovery of a new pathway. Int J Biochem Cell Biol (2014) 0.78
Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ. J Steroid Biochem Mol Biol (2016) 0.78
Cdx2 polymorphism affects the activities of vitamin D receptor in human breast cancer cell lines and human breast carcinomas. PLoS One (2015) 0.78
Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4. J Steroid Biochem Mol Biol (2016) 0.77
Identification and characterization of a vitamin D₃ decomposition product bactericidal against Helicobacter pylori. Sci Rep (2015) 0.77
A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia. Int J Mol Sci (2015) 0.77
In vivo early intervention and the therapeutic effects of 20(s)-ginsenoside rg3 on hypertrophic scar formation. PLoS One (2014) 0.77
Vitamin D as an adjuvant in melanoma therapy. Melanoma Manag (2015) 0.76
Extraskeletal actions of vitamin D. Ann N Y Acad Sci (2016) 0.75
Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes. Steroids (2016) 0.75
Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer. J Med Chem (2016) 0.75
1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells. PLoS One (2016) 0.75
Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs. Anticancer Res (2016) 0.75
Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management. Lab Invest (2017) 0.75
Vitamin D and hypertension: Prospective study and meta-analysis. PLoS One (2017) 0.75
Calcitroic Acid-A Review. ACS Chem Biol (2016) 0.75
Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models. Oncotarget (2017) 0.75
Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes. Mol Cell Endocrinol (2016) 0.75
Placental control of drug delivery. Adv Drug Deliv Rev (2016) 0.75
Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis. J Invest Dermatol (2017) 0.75
Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults. PLoS One (2017) 0.75
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. J Med Chem (2006) 8.75
Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev (2010) 4.95
Neuroendocrinology of the skin. Endocr Rev (2000) 3.34
Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol (2012) 3.21
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell (2000) 2.77
Molecular biology of steroid hormone synthesis. Endocr Rev (1988) 2.68
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem (2004) 2.42
Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J (2005) 2.23
The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem (2003) 2.22
A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc Natl Acad Sci U S A (2003) 2.13
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol (2003) 2.10
L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res (2011) 2.07
In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1. FASEB J (2012) 1.92
The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev (1997) 1.91
20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol (2008) 1.91
Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J (2008) 1.84
Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS One (2010) 1.83
Progesterone synthesis by the human placenta. Placenta (2005) 1.81
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J (2006) 1.75
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J (2001) 1.74
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71
20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes. PLoS One (2009) 1.65
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab (2004) 1.64
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab (2011) 1.58
20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells. Am J Physiol Cell Physiol (2010) 1.54
Vitamin D: an ancient hormone. Exp Dermatol (2011) 1.52
Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoS One (2009) 1.52
Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma. Hum Pathol (2013) 1.50
20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes. J Cell Physiol (2010) 1.44
ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Metab (1996) 1.41
Vitamin D metabolism and function in the skin. Mol Cell Endocrinol (2011) 1.40
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc Natl Acad Sci U S A (2011) 1.39
Expression of vitamin D receptor decreases during progression of pigmented skin lesions. Hum Pathol (2011) 1.38
The multitasking organ: recent insights into skin immune function. Immunity (2011) 1.38
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol. Chem Biol (2005) 1.36
High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives. Br J Cancer (2011) 1.35
Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32
1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol (2011) 1.27
Identification of 7(8) and 8(9) unsaturated adrenal steroid metabolites produced by patients with 7-dehydrosterol-delta7-reductase deficiency (Smith-Lemli-Opitz syndrome). J Steroid Biochem Mol Biol (2002) 1.24
Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3beta, 17alpha, 20-triol and their bioactivity in melanoma cells. Steroids (2008) 1.24
Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity. Steroids (2010) 1.23
Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells. Drug Metab Dispos (2011) 1.22
Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem (2014) 1.20
20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic. Anticancer Res (2012) 1.18
Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes. Anticancer Res (2012) 1.18
Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function. Am J Physiol Endocrinol Metab (2011) 1.18
Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2008) 1.17
20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo. J Clin Endocrinol Metab (2013) 1.17
Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol (2006) 1.16
Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. Int J Biochem Cell Biol (2012) 1.14
Potential mechanism of skin response to stress. Int J Dermatol (1996) 1.13
Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1). Drug Metab Dispos (2008) 1.13
Expression of the vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) decreases during melanoma progression. Hum Pathol (2012) 1.09
Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives. Photochem Photobiol Sci (2008) 1.09
The implications of 7-dehydrosterol-7-reductase deficiency (Smith-Lemli-Opitz syndrome) to neurosteroid production. Steroids (2004) 1.08
Relationship of 25-hydroxyvitamin D3 side chain structure to biological activity. J Biol Chem (1975) 1.08
Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity. J Invest Dermatol (2011) 1.08
Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity. Drug Metab Dispos (2010) 1.07
Gene expression profiling of Caco-2 BBe cells suggests a role for specific signaling pathways during intestinal differentiation. Physiol Genomics (2003) 1.07
Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Lett (1996) 1.06
Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? Adv Exp Med Biol (2008) 1.06
Colon cancer cells produce immunoregulatory glucocorticoids. Oncogene (2011) 1.05
Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-alpha production through activation of NF-kappaB. Int Immunol (2001) 1.04
Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein. J Biol Chem (2013) 1.02
Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity. Steroids (2010) 1.01
Role of bacterial DNA in macrophage activation by group B streptococci. Microbes Infect (2008) 0.99
Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength. Mol Cell Endocrinol (2012) 0.99
Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses. Gene (2013) 0.98
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity. Biochem Pharmacol (2012) 0.97
The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes. J Mol Med (Berl) (2007) 0.97
Novel vitamin D photoproducts and their precursors in the skin. Dermatoendocrinol (2013) 0.96
A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity. Steroids (2009) 0.95
Structure and function of the stratum corneum extracellular matrix. J Invest Dermatol (2012) 0.95
The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts. Mol Endocrinol (2009) 0.95
Side-chain specificities of human and bovine cytochromes P-450scc. Eur J Biochem (1993) 0.95
New vitamin D analogs as potential therapeutics in melanoma. Expert Rev Anticancer Ther (2012) 0.94
Design, synthesis, and biological action of 20R-hydroxyvitamin D3. J Med Chem (2012) 0.93
Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1. Drug Metab Dispos (2013) 0.92
The importance of lipids in cutaneous function. J Lipid Res (2007) 0.91
Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1. J Steroid Biochem Mol Biol (2011) 0.91
Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol. Drug Metab Dispos (2011) 0.90
The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms. Exp Dermatol (2010) 0.89
Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin. Mol Cell Endocrinol (2012) 0.86
Glucocorticoid metabolism in the developing lung: adrenal-like synthesis pathway. J Steroid Biochem Mol Biol (2013) 0.85
T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice. Ann Rheum Dis (2006) 0.81
Re-appraisal of current theories for the development and loss of epidermal pigmentation in hominins and modern humans. J Hum Evol (2013) 0.81
Effects of sidechain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR. Dermatoendocrinol (2013) 0.81
Lamellar bodies: the key to cutaneous barrier function. J Invest Dermatol (2012) 0.79
Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity. Exp Dermatol (2014) 1.52
On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids (2015) 1.01
Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J Steroid Biochem Mol Biol (2015) 1.00
Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts. Exp Dermatol (2016) 0.88
Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models. Oncotarget (2017) 0.75
Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes. Steroids (2016) 0.75