Published in J Gen Physiol on February 01, 1986
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Intracellular calcium transients underlying the short-term force-interval relationship in ferret ventricular myocardium. J Physiol (1986) 2.67
Calibration of indo-1 and resting intracellular [Ca]i in intact rabbit cardiac myocytes. Biophys J (1995) 2.00
Intracellular free calcium concentration measured with 19F NMR spectroscopy in intact ferret hearts. Proc Natl Acad Sci U S A (1987) 1.80
Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium. J Clin Invest (1990) 1.54
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Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. J Clin Invest (1987) 1.41
The relationship between contractile force and intracellular [Ca2+] in intact rat cardiac trabeculae. J Gen Physiol (1995) 1.38
A quantitative analysis of cardiac myocyte relaxation: a simulation study. Biophys J (2005) 1.38
Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol (1998) 1.32
Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation. J Physiol (1992) 1.29
Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes. J Physiol (1998) 1.29
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Mechanism of force inhibition by 2,3-butanedione monoxime in rat cardiac muscle: roles of [Ca2+]i and cross-bridge kinetics. J Physiol (1994) 1.20
Modulation of Ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. J Physiol (1990) 1.19
Influence of temperature on the calcium sensitivity of the myofilaments of skinned ventricular muscle from the rabbit. J Gen Physiol (1989) 1.18
Relaxation in ferret ventricular myocytes: unusual interplay among calcium transport systems. J Physiol (1994) 1.04
Rapid regulation of the 'second inward current' by intracellular calcium in isolated rat and ferret ventricular myocytes. J Physiol (1988) 1.04
Cross-bridge movement in rat cardiac muscle as a function of calcium concentration. J Physiol (1989) 1.02
Maximal Ca2+-activated force and myofilament Ca2+ sensitivity in intact mammalian hearts. Differential effects of inorganic phosphate and hydrogen ions. J Gen Physiol (1987) 1.01
Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts. J Clin Invest (1991) 0.96
Involvement of the protein kinase C system in calcium-force relationships in ferret aorta. Br J Pharmacol (1989) 0.95
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The effects of hypertonicity on tension and intracellular calcium concentration in ferret ventricular muscle. J Physiol (1987) 0.89
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Alterations in intracellular calcium and tension of activated ferret papillary muscle in response to step length changes. J Physiol (1993) 0.85
The effect of acidosis on the relationship between Ca2+ and force in isolated ferret cardiac muscle. J Physiol (1991) 0.85
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Mechanism of myocardial contractile depression by clinical concentrations of ethanol. A study in ferret papillary muscles. J Clin Invest (1990) 0.82
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Mechanism of the effects of acetylcholine on the contractile properties and Ca2+ transients in ferret ventricular muscles. J Physiol (1993) 0.77
Intracellular calcium and the relationship to contractility in an avian model of heart failure. J Comp Physiol B (2000) 0.77
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Steady state relation between cytoplasmic free Ca2+ concentration and force in intact frog skeletal muscle fibers. J Gen Physiol (1998) 0.76
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Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. J Physiol (1978) 6.76
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Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature (1983) 5.14
Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells. J Physiol (1975) 5.14
Aequorin luminescence: relation of light emission to calcium concentration--a calcium-independent component. Science (1977) 4.27
Model of calcium movements during activation in the sarcomere of frog skeletal muscle. Biophys J (1984) 4.26
Kinetics of reaction in calcium-activated skinned muscle fibres. Nature (1976) 3.88
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Calcium transients in aequorin-injected frog cardiac muscle. Nature (1978) 3.53
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Myofilament-generated tension oscillations during partial calcium activation and activation dependence of the sarcomere length-tension relation of skinned cardiac cells. J Gen Physiol (1978) 2.70
Effect of cross-bridge kinetics on apparent Ca2+ sensitivity. J Gen Physiol (1982) 2.59
Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat. Pflugers Arch (1983) 2.56
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55
Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell. J Gen Physiol (1985) 2.55
Cellular calcium fluctuations in mammalian heart: direct evidence from noise analysis of aequorin signals in Purkinje fibers. Proc Natl Acad Sci U S A (1983) 2.51
The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin. J Biol Chem (1982) 2.27
Myocardial sarcomere dynamics during isometric contraction. J Physiol (1975) 1.91
Calcium release in skinned cardiac cells: variations with species, tissues, and development. Fed Proc (1982) 1.90
Ryanodine modification of cardiac muscle responses to potassium-free solutions. Evidence for inhibition of sarcoplasmic reticulum calcium release. J Gen Physiol (1983) 1.86
Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction. J Gen Physiol (1984) 1.85
Scattered-light intensity fluctuations in diastolic rat cardiac muscle caused by spontaneous Ca++-dependent cellular mechanical oscillations. J Gen Physiol (1983) 1.76
Calcium transients during excitation-contraction coupling in mammalian heart: aequorin signals of canine Purkinje fibers. Science (1980) 1.73
Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle. J Physiol (1983) 1.65
Studies of cardiac muscle with a high permeability to calcium produced by treatment with ethylenediaminetetraacetic acid. J Gen Physiol (1971) 1.62
Ryanodine as a tool to determine the contributions of calcium entry and calcium release to the calcium transient and contraction of cardiac Purkinje fibers. Circ Res (1985) 1.61
Excitation-contraction coupling in cardiac Purkinje fibers. Effects of caffeine on the intracellular [Ca2+] transient, membrane currents, and contraction. J Gen Physiol (1984) 1.60
Control of cardiac contractility at the cellular level. Am J Physiol (1983) 1.45
Two elementary models for the regulation of skeletal muscle contraction by calcium. Biophys J (1983) 1.24
The hill coefficient for the Ca2+-activation of striated muscle contraction. Biophys J (1984) 1.23
Estimation of intracellular [Ca2+] by nonlinear indicators. A quantitative analysis. Biophys J (1985) 1.19
Regulation of cardiac contractile proteins. Correlations between physiology and biochemistry. Circ Res (1984) 1.15
Fluctuations in intracellular calcium concentration and their effect on tonic tension in canine cardiac Purkinje fibres. J Physiol (1985) 1.13
Activation-dependent cumulative depletions of extracellular free calcium in guinea pig atrium measured with antipyrylazo III and tetramethylmurexide. Circ Res (1983) 1.07
Control of intracellular ionized calcium concentration by sarcolemmal and intracellular mechanisms. J Mol Cell Cardiol (1984) 1.04
Effect of muscle length on the force-velocity relationship of tetanized cardiac muscle. Circ Res (1972) 1.00
Activation of thin-filament-regulated muscle by calcium ion: considerations based on nearest-neighbor lattice statistics. Proc Natl Acad Sci U S A (1982) 0.97
Load and time considerations in the force-length relation of cardiac muscle. Fed Proc (1980) 0.83
Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science (1995) 6.49
Measurement of Ca2+ concentrations in living cells. Prog Biophys Mol Biol (1982) 6.40
Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels. Neuron (1999) 5.32
Mechanism of release of calcium from sarcoplasmic reticulum of guinea-pig cardiac cells. J Physiol (1988) 4.81
Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol (1985) 4.69
Preassociation of calmodulin with voltage-gated Ca(2+) channels revealed by FRET in single living cells. Neuron (2001) 4.28
Flux of Ca2+ across the sarcoplasmic reticulum of guinea-pig cardiac cells during excitation-contraction coupling. J Physiol (1991) 3.41
Cellular and subcellular heterogeneity of [Ca2+]i in single heart cells revealed by fura-2. Science (1987) 3.39
Local, stochastic release of Ca2+ in voltage-clamped rat heart cells: visualization with confocal microscopy. J Physiol (1994) 3.12
Ca2+ sparks involving multiple Ca2+ release sites along Z-lines in rat heart cells. J Physiol (1996) 2.95
Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. Nature (2001) 2.95
Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res (1996) 2.91
Local Ca2+ transients (Ca2+ sparks) originate at transverse tubules in rat heart cells. J Physiol (1995) 2.89
Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells. Science (1994) 2.85
Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation (1998) 2.79
Voltage dependence of intracellular [Ca2+]i transients in guinea pig ventricular myocytes. Circ Res (1987) 2.78
Sudden cardiac death in heart failure. The role of abnormal repolarization. Circulation (1994) 2.78
Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science (1992) 2.75
Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J Biol Chem (2001) 2.71
Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Neuron (1994) 2.68
Intracellular calcium transients underlying the short-term force-interval relationship in ferret ventricular myocardium. J Physiol (1986) 2.67
Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes. Proc Natl Acad Sci U S A (1990) 2.61
Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity. FASEB J (1990) 2.60
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55
Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation (1997) 2.53
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Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc Natl Acad Sci U S A (1998) 2.42
Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Science (1995) 2.30
Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2. Biophys J (1990) 2.26
Macroscopic and unitary properties of physiological ion flux through L-type Ca2+ channels in guinea-pig heart cells. J Physiol (1992) 2.23
Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J Clin Invest (1986) 2.23
Processes that remove calcium from the cytoplasm during excitation-contraction coupling in intact rat heart cells. J Physiol (1994) 2.12
Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? J Physiol (1982) 2.08
Permeation in the dihydropyridine-sensitive calcium channel. Multi-ion occupancy but no anomalous mole-fraction effect between Ba2+ and Ca2+. J Gen Physiol (1990) 2.06
Ca2+ 'sparks' and waves in intact ventricular muscle resolved by confocal imaging. Circ Res (1997) 2.04
Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs. J Biol Chem (1997) 2.04
Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis. Neuron (1996) 1.98
Medical and cellular implications of stunning, hibernation, and preconditioning: an NHLBI workshop. Circulation (1998) 1.96
Preferential closed-state inactivation of neuronal calcium channels. Neuron (1998) 1.92
Theoretical analysis of the Ca2+ spark amplitude distribution. Biophys J (1998) 1.86
Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction. J Gen Physiol (1984) 1.85
Critical determinants of Ca(2+)-dependent inactivation within an EF-hand motif of L-type Ca(2+) channels. Biophys J (2000) 1.80
Intracellular free calcium concentration measured with 19F NMR spectroscopy in intact ferret hearts. Proc Natl Acad Sci U S A (1987) 1.80
Submicroscopic Ca2+ diffusion mediates inhibitory coupling between individual Ca2+ channels. Neuron (1992) 1.77
External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels. J Physiol (1996) 1.75
Sodium-calcium exchange in guinea-pig cardiac cells: exchange current and changes in intracellular Ca2+. J Physiol (1989) 1.74
Role of troponin I proteolysis in the pathogenesis of stunned myocardium. Circ Res (1997) 1.74
Calcium transients during excitation-contraction coupling in mammalian heart: aequorin signals of canine Purkinje fibers. Science (1980) 1.73
Electrophysiological properties of neonatal mouse cardiac myocytes in primary culture. J Physiol (1994) 1.71
Two molecular transitions influence cardiac sodium channel gating. Science (1989) 1.68
Structure of the sodium channel pore revealed by serial cysteine mutagenesis. Proc Natl Acad Sci U S A (1996) 1.67
Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle. Circ Res (1994) 1.66
Large currents generate cardiac Ca2+ sparks. Biophys J (2001) 1.64
Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels. J Biol Chem (1995) 1.63
Ryanodine as a tool to determine the contributions of calcium entry and calcium release to the calcium transient and contraction of cardiac Purkinje fibers. Circ Res (1985) 1.61
Excitation-contraction coupling in cardiac Purkinje fibers. Effects of caffeine on the intracellular [Ca2+] transient, membrane currents, and contraction. J Gen Physiol (1984) 1.60
Sodium-calcium exchange in heart: membrane currents and changes in [Ca2+]i. Science (1987) 1.60
Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res (1999) 1.55
Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels. J Clin Invest (1996) 1.54
Adrenergic stimulation of rat resistance arteries affects Ca(2+) sparks, Ca(2+) waves, and Ca(2+) oscillations. Am J Physiol Heart Circ Physiol (2001) 1.52
Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. Ann Thorac Surg (2001) 1.50
Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks. Circ Res (1999) 1.49
Release-independent short-term synaptic depression in cultured hippocampal neurons. J Neurosci (2000) 1.46
Mechanism of early contractile failure during hypoxia in intact ferret heart: evidence for modulation of maximal Ca2+-activated force by inorganic phosphate. Circ Res (1986) 1.46
Relative roles of Ca2(+)-dependent and Ca2(+)-independent mechanisms in hypoxic contractile dysfunction. Circulation (1990) 1.43
Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel. Circulation (1998) 1.43
Local and cellular Ca2+ transients in smooth muscle of pressurized rat resistance arteries during myogenic and agonist stimulation. J Physiol (1999) 1.42
Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. J Clin Invest (1987) 1.41
Bursts of action potential waveforms relieve G-protein inhibition of recombinant P/Q-type Ca2+ channels in HEK 293 cells. J Physiol (1997) 1.41
Macroscopic and unitary properties of physiological ion flux through T-type Ca2+ channels in guinea-pig heart cells. J Physiol (1992) 1.40
Intracellular [Ca2+] transients in voltage clamped cardiac Purkinje fibers. Pflugers Arch (1982) 1.39
Molecular motions within the pore of voltage-dependent sodium channels. Biophys J (1997) 1.39
The relationship between contractile force and intracellular [Ca2+] in intact rat cardiac trabeculae. J Gen Physiol (1995) 1.38
A high-resolution, confocal laser-scanning microscope and flash photolysis system for physiological studies. Cell Calcium (1997) 1.38
Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels. J Gen Physiol (1998) 1.37
Evolution of cardiac calcium waves from stochastic calcium sparks. Biophys J (2001) 1.34
A mutation in the pore of the sodium channel alters gating. Biophys J (1995) 1.34
Variability in frequency and characteristics of Ca2+ sparks at different release sites in rat ventricular myocytes. J Physiol (1997) 1.33
Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol (1998) 1.32
Effects of nystatin-mediated intracellular ion substitution on membrane currents in calf purkinje fibres. J Physiol (1982) 1.31
Agonist-induced [Ca2+]i waves and Ca(2+)-induced Ca2+ release in mammalian vascular smooth muscle cells. Am J Physiol (1992) 1.30
Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis. Biophys J (1997) 1.30
Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state? J Physiol (1993) 1.28
Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle. Implications for the mechanism of stunned myocardium. Circulation (1996) 1.27
Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci U S A (1997) 1.27
Quantification of [Ca2+]i in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion. Circ Res (1990) 1.27
High temporal resolution video imaging of intracellular calcium. Cell Calcium (1990) 1.26
Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998. Biophys J (1995) 1.26
Intrinsic myofilament alterations underlying the decreased contractility of stunned myocardium. A consequence of Ca2+-dependent proteolysis? Circ Res (1996) 1.25
Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis. Proc Natl Acad Sci U S A (1996) 1.25
Enhancement of ionic current and charge movement by coexpression of calcium channel beta 1A subunit with alpha 1C subunit in a human embryonic kidney cell line. J Physiol (1996) 1.25