Published in Dermatoendocrinol on April 01, 2013
Bone-induced c-kit expression in prostate cancer: a driver of intraosseous tumor growth. Int J Cancer (2014) 1.39
The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch Biochem Biophys (2014) 1.36
Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1. J Invest Dermatol (2013) 0.99
Hypoxia-independent drivers of melanoma angiogenesis. Front Oncol (2015) 0.82
2H,3H-decafluoropentane-based nanodroplets: new perspectives for oxygen delivery to hypoxic cutaneous tissues. PLoS One (2015) 0.77
Expression and significance of GRHL2 in esophageal cancer. Onco Targets Ther (2017) 0.75
The hormone factory skin never sleeps or Methusalem drugs and other ancient friends, revisited! Dermatoendocrinol (2013) 0.75
Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells. BMC Cancer (2015) 0.75
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol (1996) 15.20
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet (2012) 13.89
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res (1999) 10.65
JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res (2007) 8.79
Lysyl oxidase is essential for hypoxia-induced metastasis. Nature (2006) 8.28
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med (1995) 6.17
Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89
Germline p16 mutations in familial melanoma. Nat Genet (1994) 5.59
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature (2003) 5.57
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci (2012) 4.96
Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE (2007) 4.46
SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Nat Genet (1998) 3.82
Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today (2007) 3.36
Neuroendocrinology of the skin. Endocr Rev (2000) 3.34
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood (2011) 3.00
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res (2003) 2.93
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies. Mol Biol Cell (2001) 2.48
In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development. EMBO J (1991) 2.48
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res (1998) 2.43
Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4. Am J Hum Genet (2001) 2.43
Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res (2009) 2.27
Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol (2006) 2.25
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature (2010) 2.23
Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J (2005) 2.23
The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev (2006) 2.08
L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res (2011) 2.07
Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci (1999) 2.04
Regulation of melanogenesis--controversies and new concepts. Exp Dermatol (2007) 2.00
MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol (2003) 1.90
Melanogenesis is coupled to murine anagen: toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol (1993) 1.88
Systemic treatments for metastatic cutaneous melanoma. Cochrane Database Syst Rev (2000) 1.88
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell (2010) 1.86
BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res (2003) 1.86
Hair follicle pigmentation. J Invest Dermatol (2005) 1.84
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res (2008) 1.77
Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol (2011) 1.76
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J (2001) 1.74
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells. Int J Cancer (2009) 1.70
Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone (2005) 1.68
Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem (1997) 1.67
What are melanocytes really doing all day long...? Exp Dermatol (2009) 1.65
The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function. J Biol Chem (1994) 1.65
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab (2004) 1.64
Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway. Expert Rev Mol Med (2008) 1.64
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res (2003) 1.60
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab (2011) 1.58
The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS One (2010) 1.55
Melanocytes as "sensory" and regulatory cells in the epidermis. J Theor Biol (1993) 1.55
Melanoma: new insights and new therapies. J Invest Dermatol (2012) 1.54
SLC45A2: a novel malignant melanoma-associated gene. Hum Mutat (2008) 1.50
Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma. Nat Cell Biol (2012) 1.48
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol (2005) 1.42
Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol (2006) 1.41
Biological mechanisms that might underlie iron's effects on fetal growth and preterm birth. J Nutr (2001) 1.40
CRH functions as a growth factor/cytokine in the skin. J Cell Physiol (2006) 1.38
Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells. Oncogene (2011) 1.38
Sox proteins in melanocyte development and melanoma. Pigment Cell Melanoma Res (2010) 1.38
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma. Cancer Res (2007) 1.37
Hypoxia influences vasculogenic mimicry channel formation and tumor invasion-related protein expression in melanoma. Cancer Lett (2006) 1.34
Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development. Development (2003) 1.34
Current concepts of metastasis in melanoma. Expert Rev Dermatol (2008) 1.34
Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein. Eur J Biochem (1996) 1.31
Biochemical control of melanogenesis and melanosomal organization. J Investig Dermatol Symp Proc (1999) 1.29
Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis. Anticancer Res (1999) 1.29
Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Res (1995) 1.21
Patterns of melastatin mRNA expression in melanocytic tumors. Hum Pathol (2000) 1.21
Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. Mol Cancer Ther (2006) 1.20
Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies. Cancer J (2012) 1.18
HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med (2011) 1.17
Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding. J Invest Dermatol (2006) 1.17
Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF. J Biol Chem (2001) 1.16
Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol (2006) 1.16
Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition. Cancer Res (2009) 1.15
Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis. Pigment Cell Melanoma Res (2009) 1.12
Neuroendocrine activity of the melanocyte. Exp Dermatol (2009) 1.12
CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration. Br J Cancer (2011) 1.12
Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke (1994) 1.10
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF. Proc Natl Acad Sci U S A (2011) 1.09
Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop. Oncogene (2011) 1.08
c-KIT signaling as the driving oncogenic event in sub-groups of melanomas. Histol Histopathol (2009) 1.08
FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973. EJNMMI Res (2012) 1.08
HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features. Am J Surg Pathol (2010) 1.07
Characterization of corticotropin-releasing hormone (CRH) in human skin. J Clin Endocrinol Metab (1998) 1.06
Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Lett (1996) 1.06
Current advances and perspectives in the treatment of advanced melanoma. J Dtsch Dermatol Ges (2012) 1.06
Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. PLoS One (2010) 1.06
Distinctive distribution of AIM1 polymorphism among major human populations with different skin color. J Hum Genet (2002) 1.06
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors. Oncogene (2010) 1.05
What's the use of generating melanin? Exp Dermatol (1999) 1.04
Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions. Mol Cancer (2009) 1.03
Molecular basis of human piebaldism. J Invest Dermatol (1994) 1.03
Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells. Cancer Res (2007) 1.03
On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol (2009) 1.02
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res (2007) 3.01
Prognostic significance of growth kinetics in newly diagnosed glioblastomas revealed by combining serial imaging with a novel biomathematical model. Cancer Res (2009) 1.88
Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J (2008) 1.84
Neuroimmunology of stress: skin takes center stage. J Invest Dermatol (2006) 1.72
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab (2011) 1.58
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res (2012) 1.55
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol (2002) 1.37
Current concepts of metastasis in melanoma. Expert Rev Dermatol (2008) 1.34
Molecular diagnostics in melanoma. J Am Acad Dermatol (2005) 1.33
Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. FASEB J (2006) 1.29
Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin. Int J Biochem Cell Biol (2008) 1.27
Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet (2006) 1.25
Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity. Steroids (2010) 1.23
Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem (2004) 1.22
Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells. Drug Metab Dispos (2011) 1.22
20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic. Anticancer Res (2012) 1.18
Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2008) 1.17
Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol (2006) 1.16
Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab (2008) 1.15
Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1). Drug Metab Dispos (2008) 1.13
Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J (2007) 1.12
Inhibition of melanoma metastases by fenofibrate. Arch Dermatol Res (2004) 1.08
Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity. Drug Metab Dispos (2010) 1.07
Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res (2009) 1.03
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol (2008) 1.03
The skin as a mirror of the soul: exploring the possible roles of serotonin. Exp Dermatol (2007) 1.02
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res (2013) 1.02
Melanocyte receptors: clinical implications and therapeutic relevance. Dermatol Clin (2007) 1.01
Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol (2006) 1.00
Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci (2002) 0.99
Role of TRPM in melanocytes and melanoma. Exp Dermatol (2012) 0.98
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity. Biochem Pharmacol (2012) 0.97
A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity. Steroids (2009) 0.95
Corticotropin releasing factor receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J Invest Dermatol (2002) 0.95
The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance. J Biol Chem (2013) 0.95
Intracellular calcium measurements of single human skin cells after stimulation with corticotropin-releasing factor and urocortin using confocal laser scanning microscopy. J Cell Sci (2003) 0.94
Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis. Cancer Res (2011) 0.94
Melatonin and the hair follicle. J Pineal Res (2008) 0.93
Melanocytic proliferations associated with lichen sclerosus. Arch Dermatol (2002) 0.92
Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. FASEB J (2006) 0.90
Stress-linked cortisol concentrations in hair: what we know and what we need to know. Rev Neurosci (2011) 0.90
A novel metabolic pathway of melatonin: oxidation by cytochrome C. Biochemistry (2005) 0.90
The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms. Exp Dermatol (2010) 0.89
Splenic eumelanin differs from hair eumelanin in C57BL/6 mice. Acta Biochim Pol (2005) 0.89
Malignant melanoma 2003: predisposition, diagnosis, prognosis, and staging. Am J Clin Pathol (2003) 0.88
VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol (2010) 0.87
Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer. Breast Cancer Res (2013) 0.85
Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer. Cancer Prev Res (Phila) (2013) 0.85
Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. J Pineal Res (2008) 0.85
Immuno-histochemical evaluation of solar lentigines: The association of KGF/KGFR and other factors with lesion development. J Dermatol Sci (2010) 0.84
Cooling skin cancer: menthol inhibits melanoma growth. Focus on "TRPM8 activation suppresses cellular viability in human melanoma". Am J Physiol Cell Physiol (2008) 0.83
Serotonin metabolism in rat skin: characterization by liquid chromatography-mass spectrometry. Arch Biochem Biophys (2004) 0.83
Biomarkers in melanoma: stage III and IV disease. Expert Rev Mol Diagn (2005) 0.83
Melanoma update: diagnostic and prognostic factors that can effectively shape and personalize management. Biomark Med (2011) 0.81
Biomarkers in melanoma: staging, prognosis and detection of early metastases. Expert Rev Mol Diagn (2003) 0.81
Coming of age of melanogenesis-related proteins. Arch Pathol Lab Med (2002) 0.80
Cutaneous metabolism of vitamin B-6. J Invest Dermatol (2003) 0.80
Possible mechanisms of hypopigmentation in lichen sclerosus. Am J Dermatopathol (2002) 0.80
Does p53 regulate skin pigmentation by controlling proopiomelanocortin gene transcription? Pigment Cell Res (2007) 0.80
Biomarkers in melanoma: predisposition, screening and diagnosis. Expert Rev Mol Diagn (2003) 0.80
A novel microarray to evaluate stress-related genes in skin: effect of ultraviolet light radiation. Gene (2004) 0.79
The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi. J Cutan Pathol (2010) 0.79
Nicotinic receptor signaling in nonexcitable epithelial cells: paradigm shifting from ion current to kinase cascade. Focus on "Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases". Am J Physiol Cell Physiol (2010) 0.79
On the role of environmental humidity on cortisol production by epidermal keratinocytes. Exp Dermatol (2014) 0.79
Volar melanotic macules in a gardener: a case report and review of the literature. Am J Dermatopathol (2008) 0.78
A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion - baboons (Papio spp.). Fetal Diagn Ther (2014) 0.77
What are the clinicopathologic features of matricoma? Am J Dermatopathol (2003) 0.75
Beta-endorphin/mu-opiate receptor system in the skin. J Invest Dermatol (2003) 0.75
KU812 basophils express urocortin, CRH-R, MC1R and steroidogenic enzymes and secrete progesterone. Exp Dermatol (2012) 0.75
Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case-Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors. Am J Dermatopathol (2016) 0.75
Acquired primary cutaneous ganglioneuroma with adipocytic metaplasia: "An end point of melanocytic 'maturation'?" a case report and meta-analysis with comparison to a cross-sectional study of neurotized melanocytic nevi. Am J Dermatopathol (2011) 0.75
Epidermodysplasia verruciformis and cutaneous human papillomavirus DNA, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. Am J Dermatopathol (2007) 0.75
John Martin Wood (1938-2008)--pioneering biochemist, educator and communicator. Exp Dermatol (2008) 0.75