Published in Nucleus on November 08, 2013
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Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. PLoS One (2017) 0.75
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature (2008) 10.95
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell (2010) 6.71
Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature (2008) 4.92
Nucleosome destabilization in the epigenetic regulation of gene expression. Nat Rev Genet (2008) 4.69
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure. Nature (2013) 4.47
Comparative epigenomic analysis of murine and human adipogenesis. Cell (2010) 4.08
Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell (1993) 3.77
Characterization of the Drosophila melanogaster genome at the nuclear lamina. Nat Genet (2006) 3.44
Single-cell dynamics of genome-nuclear lamina interactions. Cell (2013) 3.03
Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Cell (1987) 2.88
Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol (1997) 2.82
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. Cell (2012) 2.67
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell (2013) 2.38
Propagation of adipogenic signals through an epigenomic transition state. Genes Dev (2010) 2.23
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell (2012) 2.20
eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci. Mol Cell (2013) 2.12
Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J Biol Chem (1994) 2.11
Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. Genome Res (2012) 2.04
Nuclear positioning. Cell (2013) 2.01
MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin. J Biol Chem (2000) 1.95
Isolation and transcription profiling of purified uncultured human stromal stem cells: alteration of gene expression after in vitro cell culture. Mol Biol Cell (2005) 1.91
Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature (2013) 1.89
Nuclear lamins and laminopathies. J Pathol (2011) 1.89
When lamins go bad: nuclear structure and disease. Cell (2013) 1.84
The nuclear envelope as a signaling node in development and disease. Dev Cell (2009) 1.81
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev (2013) 1.78
The nuclear lamins: flexibility in function. Nat Rev Mol Cell Biol (2012) 1.76
Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem (2002) 1.72
Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2. Genome Biol (2010) 1.69
Role of A-type lamins in signaling, transcription, and chromatin organization. J Cell Biol (2009) 1.68
Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome. Genome Res (2012) 1.63
Genome-nuclear lamina interactions and gene regulation. Curr Opin Cell Biol (2010) 1.55
The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. J Cell Sci (2005) 1.54
Nuclear lamin functions and disease. Trends Genet (2012) 1.52
The carboxyl-terminal region common to lamins A and C contains a DNA binding domain. Biochemistry (2003) 1.50
An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity. Curr Biol (2011) 1.43
The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers. Hum Mol Genet (2006) 1.32
Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1. EMBO Rep (2001) 1.30
Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Res (2013) 1.23
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev (2013) 1.23
The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling. Cell Stem Cell (2013) 1.19
Nuclear lamina at the crossroads of the cytoplasm and nucleus. J Struct Biol (2011) 1.19
Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation. J Biol Chem (1988) 1.16
Lamina-independent lamins in the nuclear interior serve important functions. Cold Spring Harb Symp Quant Biol (2011) 1.15
The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol (2011) 1.14
Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. Genome Biol (2013) 1.11
Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells. Nucleus (2011) 1.10
The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome. PLoS One (2010) 1.09
The nuclear envelope as a chromatin organizer. Nucleus (2011) 1.06
Mapping of lamin A- and progerin-interacting genome regions. Chromosoma (2012) 1.01
Actin-filled nuclear invaginations indicate degree of cell de-differentiation. Differentiation (2003) 0.98
Loss of Bright/ARID3a function promotes developmental plasticity. Stem Cells (2010) 0.94
Closing the (nuclear) envelope on the genome: how nuclear lamins interact with promoters and modulate gene expression. Bioessays (2013) 0.94
Reactivation of autophagy ameliorates LMNA cardiomyopathy. Autophagy (2012) 0.86