1
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C-H bond functionalization: emerging synthetic tools for natural products and pharmaceuticals.
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Angew Chem Int Ed Engl
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2012
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2.24
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2
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Tag strategy for separation and recovery.
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Chem Rev
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2002
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1.88
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3
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Potassium t-butoxide alone can promote the biaryl coupling of electron-deficient nitrogen heterocycles and haloarenes.
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Org Lett
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2008
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1.12
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4
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A grossly warped nanographene and the consequences of multiple odd-membered-ring defects.
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Nat Chem
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2013
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1.07
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5
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Initiation of carbon nanotube growth by well-defined carbon nanorings.
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Nat Chem
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2013
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1.03
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6
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Selective synthesis of [12]cycloparaphenylene.
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Angew Chem Int Ed Engl
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2009
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1.02
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7
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Decarbonylative C-H coupling of azoles and aryl esters: unprecedented nickel catalysis and application to the synthesis of muscoride A.
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J Am Chem Soc
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2012
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1.00
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8
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Synthesis of cycloparaphenylenes and related carbon nanorings: a step toward the controlled synthesis of carbon nanotubes.
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Acc Chem Res
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2012
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0.98
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9
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Fe-catalyzed oxidative coupling of heteroarenes and methylamines.
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Chem Asian J
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2009
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0.96
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10
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Direct C-H arylation of (hetero)arenes with aryl iodides via rhodium catalysis.
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J Am Chem Soc
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2006
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0.95
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11
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Synthesis and properties of [9]cyclo-1,4-naphthylene: a π-extended carbon nanoring.
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J Am Chem Soc
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2012
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0.92
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12
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A general catalyst for the β-selective C-H bond arylation of thiophenes with iodoarenes.
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Angew Chem Int Ed Engl
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2010
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0.92
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13
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Oxidative biaryl coupling of thiophenes and thiazoles with arylboronic acids through palladium catalysis: otherwise difficult C4-selective C-H arylation enabled by boronic acids.
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Angew Chem Int Ed Engl
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2011
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0.91
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14
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Coupling of nitrogen heteroaromatics and alkanes without transition metals: a new oxidative cross-coupling at C-H/C-H bonds.
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Chemistry
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2009
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0.90
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15
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Direct arylation of polycyclic aromatic hydrocarbons through palladium catalysis.
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J Am Chem Soc
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2011
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0.90
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16
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Theoretical studies on the structures and strain energies of cycloparaphenylenes.
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Org Lett
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2010
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0.90
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17
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Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives.
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J Am Chem Soc
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2011
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0.89
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18
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Synthesis and racemization process of chiral carbon nanorings: a step toward the chemical synthesis of chiral carbon nanotubes.
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Org Lett
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2011
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0.88
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19
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Palladium-catalyzed C-H activation taken to the limit. Flattening an aromatic bowl by total arylation.
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J Am Chem Soc
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2012
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0.88
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20
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"Cation pool" method based on C-C bond dissociation. Effective generation of monocations and dications.
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J Am Chem Soc
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2005
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0.87
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21
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Nickel-catalyzed biaryl coupling of heteroarenes and aryl halides/triflates.
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Org Lett
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2009
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0.87
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22
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Synthesis of dragmacidin D via direct C-H couplings.
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J Am Chem Soc
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2011
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0.87
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23
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Iridium-Catalyzed [5 + 1] Cycloaddition: Allenylcyclopropane as a Five-Carbon Assembling Unit.
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J Org Chem
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1998
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0.86
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24
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Key mechanistic features of Ni-catalyzed C-H/C-O biaryl coupling of azoles and naphthalen-2-yl pivalates.
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J Am Chem Soc
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2014
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0.86
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25
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Catalytic four-component assembly based on allenylboronate platform: new access to privileged allylic amine structures.
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J Am Chem Soc
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2006
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0.85
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26
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A modular and size-selective synthesis of [n]cycloparaphenylenes: a step toward the selective synthesis of [n,n] single-walled carbon nanotubes.
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Angew Chem Int Ed Engl
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2010
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0.85
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27
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Synthesis and properties of cycloparaphenylene-2,5-pyridylidene: a nitrogen-containing carbon nanoring.
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Org Lett
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2012
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0.83
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28
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Iridium catalysis for C-H bond arylation of heteroarenes with iodoarenes.
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Angew Chem Int Ed Engl
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2009
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0.83
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29
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Synthesis of extended π-systems through C-H activation.
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Angew Chem Int Ed Engl
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2014
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0.83
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30
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Nickel-Catalyzed Cross-Coupling of Dienyl Phosphates with Grignard Reagents in the Synthesis of 2-Substituted 1,3-Dienes.
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J Org Chem
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1999
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0.83
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31
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β-Selective C-H arylation of pyrroles leading to concise syntheses of lamellarins C and I.
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J Am Chem Soc
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2014
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0.82
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32
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Concise synthesis and crystal structure of [12]cycloparaphenylene.
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Angew Chem Int Ed Engl
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2011
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0.82
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33
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Stereodivergent synthesis of arylcyclopropylamines by sequential C-H borylation and Suzuki-Miyaura coupling.
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Angew Chem Int Ed Engl
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2014
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0.82
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34
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Sequential Pd- and Rh-catalyzed three-component cyclization with allenylboronate platform.
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Org Lett
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2006
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0.82
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35
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All-benzene carbon nanocages: size-selective synthesis, photophysical properties, and crystal structure.
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J Am Chem Soc
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2014
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0.82
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36
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Programmed synthesis of tetraarylthiophenes through sequential C-H arylation.
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J Am Chem Soc
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2009
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0.82
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37
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Pd(OAc)2/o-chloranil/M(OTf)n: a catalyst for the direct C-H arylation of polycyclic aromatic hydrocarbons with boryl-, silyl-, and unfunctionalized arenes.
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Org Lett
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2011
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0.82
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38
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Catalytic C-H imidation of aromatic cores of functional molecules: ligand-accelerated cu catalysis and application to materials- and biology-oriented aromatics.
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J Am Chem Soc
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2015
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0.82
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39
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Exploitation of an additional hydrophobic pocket of σ1 receptors: late-stage diverse modifications of spirocyclic thiophenes by C-H bond functionalization.
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Org Biomol Chem
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2011
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0.81
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40
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A nickel catalyst for the addition of organoboronate esters to ketones and aldehydes.
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Org Lett
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2009
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0.81
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41
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Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling.
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J Am Chem Soc
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2013
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0.81
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42
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Concise syntheses of dictyodendrins A and F by a sequential C-H functionalization strategy.
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J Am Chem Soc
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2015
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0.80
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43
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Synthesis of dihydrobenzo[b]furans by diastereoselective acyloxyarylation.
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Chem Commun (Camb)
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2014
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0.80
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44
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Copper-mediated C-H bond arylation of arenes with arylboronic acids.
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Org Lett
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2008
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0.80
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45
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Pd-catalyzed direct C-H bond functionalization of spirocyclic σ1 ligands: generation of a pharmacophore model and analysis of the reverse binding mode by docking into a 3D homology model of the σ1 receptor.
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J Med Chem
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2012
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0.79
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46
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Thiophene-based, radial π-conjugation: synthesis, structure, and photophysical properties of cyclo-1,4-phenylene-2',5'-thienylenes.
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Angew Chem Int Ed Engl
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2014
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0.79
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47
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Combined experimental and theoretical studies on the photophysical properties of cycloparaphenylenes.
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Org Biomol Chem
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2012
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0.79
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48
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Mechanistic studies on the Pd-catalyzed direct C-H arylation of 2-substituted thiophene derivatives with arylpalladium bipyridyl complexes.
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Chem Asian J
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2012
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0.78
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49
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η6-Cycloparaphenylene transition metal complexes: synthesis, structure, photophysical properties, and application to the selective monofunctionalization of cycloparaphenylenes.
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J Am Chem Soc
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2015
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0.78
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50
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The 1,1-carboboration of bis(alkynyl)phosphanes as a route to phosphole compounds.
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Angew Chem Int Ed Engl
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2012
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0.78
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51
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Cationic carbohydroxylation of alkenes and alkynes using the cation pool method.
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Org Lett
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2004
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0.78
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52
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Nickel-catalyzed α-arylation of ketones with phenol derivatives.
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Angew Chem Int Ed Engl
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2014
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0.78
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53
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Cycloparaphenylene-based ionic donor-acceptor supramolecule: isolation and characterization of Li⁺@C60⊂[10]CPP.
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Angew Chem Int Ed Engl
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2015
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0.78
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54
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Synthesis and properties of cycloparaphenylene-2,7-pyrenylene: a pyrene-containing carbon nanoring.
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Chem Commun (Camb)
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2014
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0.78
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55
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Palladium-catalyzed cross-coupling reactions of (2-pyridyl)allyldimethylsilanes with aryl iodides.
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Org Lett
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2006
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0.78
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56
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Synthesis and dimerization of chloro[10]cycloparaphenylene: a directly connected cycloparaphenylene dimer.
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Org Lett
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2014
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0.77
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57
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C-H alkenylation of azoles with enols and esters by nickel catalysis.
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Angew Chem Int Ed Engl
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2013
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0.77
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58
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Selective introduction of organic groups to C60 and C70 using organoboron compounds and rhodium catalyst: a new synthetic approach to organo(hydro)fullerenes.
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Chem Asian J
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2010
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0.77
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59
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Nickel-catalyzed C-H arylation of azoles with haloarenes: scope, mechanism, and applications to the synthesis of bioactive molecules.
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Chemistry
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2011
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0.77
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60
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Selective synthesis of [7]- and [8]cycloparaphenylenes.
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Chem Commun (Camb)
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2014
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0.77
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61
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A bench-stable Pd catalyst for the hydroarylation of fullerene with boronic acids.
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Org Lett
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2008
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0.77
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62
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Rhodium-catalyzed C-H bond arylation of arenes.
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Top Curr Chem
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2010
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0.77
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63
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Synthesis of thiophene-based TAK-779 analogues by C-H arylation.
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J Org Chem
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2013
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0.77
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64
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Size-selective complexation and extraction of endohedral metallofullerenes with cycloparaphenylene.
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Angew Chem Int Ed Engl
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2014
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0.77
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65
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C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors.
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Org Biomol Chem
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2016
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0.77
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66
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Ni-Catalyzed α-arylation of esters and amides with phenol derivatives.
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Chem Commun (Camb)
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2014
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0.76
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67
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Controlled alcohol-carbonyl interconversion by nickel catalysis.
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Angew Chem Int Ed Engl
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2011
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0.76
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68
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Rh-catalyzed arylation and alkenylation of C(60) using organoboron compounds.
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J Am Chem Soc
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2007
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0.76
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69
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Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones.
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Bioorg Med Chem
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2013
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0.76
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70
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Copper-catalyzed allylation of carbonyl derivatives using allyl(2-pyridyl)silanes.
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Org Lett
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2005
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0.76
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71
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1,3,5-Triaryl 2-pyridylidene: base-promoted generation and complexation.
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Chem Commun (Camb)
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2012
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0.76
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72
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Pyridine-based dicarbene ligand: synthesis and structure of a bis-2-pyridylidene palladium complex.
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Chem Commun (Camb)
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2013
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0.76
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73
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists.
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Org Biomol Chem
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2015
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0.76
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74
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Regioselective unsymmetrical tetraallylation of C(60) through palladium catalysis.
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J Am Chem Soc
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2009
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0.76
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75
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Structure-affinity-relationship study of bicyclic sigma receptor ligands.
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Cent Nerv Syst Agents Med Chem
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2009
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0.76
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76
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Generation of pyridyl coordinated organosilicon cation pool by oxidative Si-Si bond dissociation.
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Beilstein J Org Chem
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2007
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0.75
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77
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Palladium(II)-catalyzed conjugate phosphination of electron-deficient acceptors.
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Org Lett
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2009
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0.75
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78
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Functionalization of a simple dithienylethene via palladium-catalyzed regioselective direct arylation.
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Org Lett
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2011
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0.75
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79
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Aziridinofullerene: a versatile platform for functionalized fullerenes.
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J Am Chem Soc
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2011
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0.75
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80
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Porous frameworks constructed by non-covalent linking of substitution-inert metal complexes.
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Dalton Trans
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2015
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0.75
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81
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Palladium-catalyzed carbon-carbon bond formation and cleavage of organo(hydro)fullerenes.
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Chemistry
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2009
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0.75
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82
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Branch-selective allylic C-H carboxylation of terminal alkenes by Pd/sox catalyst.
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Org Lett
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2014
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0.75
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83
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Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling.
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Org Biomol Chem
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2013
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0.75
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84
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Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform.
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J Org Chem
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2005
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0.75
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85
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Manganese-catalyzed intermolecular C-H/C-H coupling of carbonyls and heteroarenes.
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Chem Commun (Camb)
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2014
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0.75
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86
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Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids.
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Org Lett
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2016
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0.75
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