PubRank

Gunther Hartmann

Author PubWeight™ 188.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007 34.03
2 5'-Triphosphate RNA is the ligand for RIG-I. Science 2006 15.78
3 Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002 7.60
4 Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 2005 7.18
5 RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009 6.97
6 Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 2009 5.70
7 Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009 5.00
8 Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 2013 3.92
9 Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol 2009 3.58
10 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 2008 3.13
11 Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J Immunol 2003 2.87
12 Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest 2009 2.85
13 Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 2013 2.79
14 Preferential expression and function of Toll-like receptor 3 in human astrocytes. J Neuroimmunol 2004 2.39
15 TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 2008 2.37
16 Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J Immunol 2005 2.31
17 Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol 2010 2.30
18 Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J Virol 2005 2.16
19 Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol 2010 2.13
20 siRNA and isRNA: two edges of one sword. Mol Ther 2006 2.02
21 Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 2011 1.96
22 Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2003 1.95
23 Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J Immunol 2004 1.85
24 Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 2013 1.82
25 Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol 2002 1.76
26 Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells. J Biol Chem 2004 1.61
27 Approaching the RNA ligand for RIG-I? Immunol Rev 2009 1.57
28 B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotides. Clin Cancer Res 2005 1.49
29 Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model. J Immunol 2002 1.47
30 SiRNA delivery with exosome nanoparticles. Nat Biotechnol 2011 1.46
31 Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res 2003 1.44
32 IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA. J Immunol 2004 1.40
33 Plasmacytoid dendritic cells: the key to CpG. Hum Immunol 2002 1.28
34 The chase for the RIG-I ligand--recent advances. Mol Ther 2010 1.27
35 Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes. J Immunol 2009 1.25
36 Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells. Blood 2003 1.25
37 T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. J Immunol 2006 1.23
38 CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood 2003 1.19
39 Accessing the therapeutic potential of immunostimulatory nucleic acids. Curr Opin Immunol 2008 1.18
40 Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer. Cancer Res 2013 1.17
41 Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy. Eur J Immunol 2002 1.14
42 RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J 2012 1.14
43 Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 2009 1.07
44 CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. Eur J Immunol 2005 1.06
45 Activation of endothelial toll-like receptor 3 impairs endothelial function. Circ Res 2011 1.06
46 Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation. J Immunol 2009 1.04
47 Exosomes as nucleic acid nanocarriers. Adv Drug Deliv Rev 2012 1.04
48 Delivery by cationic gelatin nanoparticles strongly increases the immunostimulatory effects of CpG oligonucleotides. Pharm Res 2007 1.04
49 Staphylococcus aureus protein A triggers T cell-independent B cell proliferation by sensitizing B cells for TLR2 ligands. J Immunol 2007 1.02
50 RNA recognition via TLR7 and TLR8. Handb Exp Pharmacol 2008 1.01
51 Turning tumors into vaccines: co-opting the innate immune system. Immunity 2013 0.99
52 Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer. Int J Cancer 2006 0.98
53 CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J Immunol 2003 0.97
54 Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium. Clin Vaccine Immunol 2006 0.97
55 Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells. Cancer Res 2010 0.96
56 Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 2009 0.95
57 Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA. J Leukoc Biol 2009 0.94
58 Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res 2009 0.94
59 Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7. J Immunol 2009 0.93
60 Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters. Pigment Cell Melanoma Res 2010 0.92
61 CpG oligonucleotides: novel regulators of osteoclast differentiation. FASEB J 2002 0.92
62 5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice. Gastroenterology 2011 0.92
63 Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma. Stem Cells 2013 0.92
64 Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells. Eur J Immunol 2011 0.92
65 RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells. PLoS One 2013 0.92
66 Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. J Allergy Clin Immunol 2009 0.91
67 Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response. Blood 2007 0.91
68 Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions. Front Mol Neurosci 2012 0.90
69 Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer. Cancer Chemother Pharmacol 2010 0.90
70 Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. Immunology 2009 0.90
71 AChE and RACK1 promote the anti-inflammatory properties of fluoxetine. J Mol Neurosci 2013 0.87
72 Influence of acute exposure to high altitude on basal and postprandial plasma levels of gastroenteropancreatic peptides. PLoS One 2012 0.87
73 Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles. Oligonucleotides 2006 0.87
74 Recent advances in immunostimulatory CpG oligonucleotides. Curr Opin Mol Ther 2003 0.84
75 Activation of dendritic cells and induction of T cell responses by HPV 16 L1/E7 chimeric virus-like particles are enhanced by CpG ODN or sorbitol. Antivir Ther 2004 0.83
76 TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA. J Immunother 2009 0.83
77 Immunohistological analysis of in-transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta-interferon: a case report. J Dermatol 2012 0.83
78 A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA. PLoS One 2013 0.82
79 CpG oligonucleotides elicit antitumor responses in a human melanoma NOD/SCID xenotransplantation model. J Invest Dermatol 2004 0.82
80 Mitf silencing cooperates with IL-12 gene transfer to inhibit melanoma in mice. Int Immunopharmacol 2010 0.80
81 Monocyte-mediated inhibition of TLR9-dependent IFN-α induction in plasmacytoid dendritic cells questions bacterial DNA as the active ingredient of bacterial lysates. J Immunol 2010 0.79
82 Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells. Biochim Biophys Acta 2009 0.78
83 Endothelial RIG-I activation impairs endothelial function. Biochem Biophys Res Commun 2012 0.78
84 VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation. Eur J Clin Pharmacol 2012 0.77
85 Evaluating the immune responses stimulated by CpG oligodeoxynucleotides. Nucleic Acids Res Suppl 2003 0.76
86 Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients. J Cancer Res Clin Oncol 2013 0.76
87 Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Elife 2016 0.76
88 Calponin-h2: a potential serum marker for the early detection of human breast cancer? Tumour Biol 2014 0.75
89 Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy. J Virol 2014 0.75
90 Nucleic acid adjuvants: toward an educated vaccine. Adv Immunol 2012 0.75
91 Delivery with polycations extends the immunostimulant Ribomunyl into a potent antiviral Toll-like receptor 7/8 agonist. Antivir Ther 2011 0.75
92 A message from the Oligonucleotide Therapeutics Society. Nucleic Acid Ther 2012 0.75
93 Enzymatic synthesis and purification of a defined RIG-I ligand. Methods Mol Biol 2014 0.75
94 Identification of specific nuclear structural protein alterations in human breast cancer. J Cell Biochem 2011 0.75