Published in Immunity on December 12, 2013
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol (2015) 1.68
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med (2016) 1.45
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep (2014) 1.27
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A (2015) 1.25
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein. Cell Host Microbe (2015) 1.09
cGAS surveillance of micronuclei links genome instability to innate immunity. Nature (2017) 1.04
Discriminating self from non-self in nucleic acid sensing. Nat Rev Immunol (2016) 1.02
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat Immunol (2016) 0.98
Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell (2014) 0.96
Structural biology of innate immunity. Annu Rev Immunol (2015) 0.93
Activation and regulation of DNA-driven immune responses. Microbiol Mol Biol Rev (2015) 0.92
International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92
Transcription of inflammatory genes: long noncoding RNA and beyond. J Interferon Cytokine Res (2014) 0.89
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING. Nucleic Acids Res (2014) 0.85
cGAS dimerization entangles DNA recognition. Immunity (2013) 0.83
The mechanism of double-stranded DNA sensing through the cGAS-STING pathway. Cytokine Growth Factor Rev (2014) 0.83
OASes and STING: adaptive evolution in concert. Genome Biol Evol (2015) 0.81
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun (2017) 0.81
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape. PLoS Genet (2015) 0.80
Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells. Sci Immunol (2017) 0.78
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response. Sci Rep (2016) 0.78
cGAS is essential for the antitumor effect of immune checkpoint blockade. Proc Natl Acad Sci U S A (2017) 0.77
Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses. J Virol (2015) 0.77
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING. Proc Natl Acad Sci U S A (2015) 0.77
Intracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogens. J Leukoc Biol (2014) 0.77
Evasion of Host Immune Defenses by Human Papillomavirus. Virus Res (2016) 0.77
Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc Natl Acad Sci U S A (2016) 0.76
Advanced Design of Dumbbell-shaped Genetic Minimal Vectors Improves Non-coding and Coding RNA Expression. Mol Ther (2016) 0.76
Immune sensing of nucleic acids in inflammatory skin diseases. Semin Immunopathol (2014) 0.76
Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression. Oncoimmunology (2016) 0.76
An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway. Cell Chem Biol (2016) 0.75
DNA sensor cGAS-mediated immune recognition. Protein Cell (2016) 0.75
The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response. PLoS Pathog (2017) 0.75
Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS. Bioessays (2014) 0.75
Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1. Sci Rep (2016) 0.75
Single amino acid change in STING leads to constitutive active signaling. PLoS One (2015) 0.75
Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract. Curr HIV/AIDS Rep (2016) 0.75
SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing. PLoS Pathog (2017) 0.75
Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6. Sci Rep (2015) 0.75
RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling. EMBO Rep (2016) 0.75
Interaction between susceptibility loci in cGAS-STING pathway, MHC gene and HPV infection on the risk of cervical precancerous lesions in Chinese population. Oncotarget (2016) 0.75
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature (2017) 0.75
cGAS is activated by DNA in a length-dependent manner. EMBO Rep (2017) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. Biophys J (1999) 13.18
A diverse range of gene products are effectors of the type I interferon antiviral response. Nature (2011) 12.86
The atomic structure of protein-protein recognition sites. J Mol Biol (1999) 12.63
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature (2008) 10.73
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature (2009) 9.74
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science (2012) 7.08
STING is a direct innate immune sensor of cyclic di-GMP. Nature (2011) 6.44
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A (2009) 4.46
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell (2013) 3.92
Intracellular DNA recognition. Nat Rev Immunol (2010) 3.70
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature (2013) 3.60
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal (2012) 3.59
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (2013) 3.10
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep (2013) 3.08
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell (2013) 2.97
Structural mechanism of cytosolic DNA sensing by cGAS. Nature (2013) 2.50
RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol Rev (2011) 2.48
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity (2012) 2.47
Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell (2012) 2.38
Cytosolic DNA sensors regulating type I interferon induction. Trends Immunol (2011) 2.35
STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol (2013) 2.23
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity (2009) 2.21
Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol (2011) 2.19
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat Struct Mol Biol (2012) 2.18
Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase. Mol Cell (2003) 2.16
The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol (2012) 2.04
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell (2013) 1.82
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat Struct Mol Biol (2012) 1.82
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. Proc Natl Acad Sci U S A (2013) 1.46
Cyclic dinucleotides and the innate immune response. Cell (2013) 1.21
STING-dependent signaling. Nat Immunol (2011) 1.08
Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2. J Mol Biol (2015) 1.51
Structural insights into the functions of TBK1 in innate antimicrobial immunity. Structure (2013) 0.89
The mechanism of double-stranded DNA sensing through the cGAS-STING pathway. Cytokine Growth Factor Rev (2014) 0.83