PubRank

Steven L Kunkel

Author PubWeight™ 146.57‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 2009 3.76
2 TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 2008 3.62
3 Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J Cereb Blood Flow Metab 2005 2.45
4 Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci 2003 2.21
5 The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth. Blood 2010 1.97
6 Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol 2011 1.91
7 Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood 2007 1.64
8 The chronic consequences of severe sepsis. J Leukoc Biol 2003 1.62
9 Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Am J Respir Crit Care Med 2004 1.59
10 Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy 2005 1.57
11 Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J Immunol 2009 1.51
12 Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arterioscler Thromb Vasc Biol 2004 1.49
13 Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood 2004 1.44
14 Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury. Thromb Haemost 2015 1.43
15 CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res 2011 1.43
16 TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest 2008 1.43
17 CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis. Cytokine 2003 1.42
18 Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation. J Immunol 2002 1.41
19 Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011 1.38
20 Immunomodulatory role of CXCR2 during experimental septic peritonitis. J Immunol 2003 1.36
21 Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J Exp Med 2007 1.35
22 Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol 2002 1.34
23 A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone-marrow-derived macrophages to Toll-like receptor agonists. J Leukoc Biol 2007 1.33
24 Lung contusion: inflammatory mechanisms and interaction with other injuries. Shock 2009 1.32
25 Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol 2006 1.30
26 Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells. J Immunol 2003 1.27
27 Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Am J Respir Cell Mol Biol 2003 1.27
28 Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia. J Immunol 2009 1.27
29 MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection. J Immunol 2007 1.26
30 Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells. Proc Natl Acad Sci U S A 2009 1.26
31 Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun 2005 1.25
32 Septic mice are susceptible to pulmonary aspergillosis. Am J Pathol 2003 1.25
33 A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am J Pathol 2008 1.24
34 Chemokines provide the sustained inflammatory bridge between innate and acquired immunity. Cytokine Growth Factor Rev 2005 1.23
35 Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage. Am J Pathol 2006 1.22
36 TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis. Sci Transl Med 2010 1.21
37 RANTES (CCL5) production during primary respiratory syncytial virus infection exacerbates airway disease. Eur J Immunol 2002 1.21
38 Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Am J Pathol 2004 1.20
39 Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice. FASEB J 2002 1.19
40 IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol 2007 1.18
41 Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Am J Pathol 2004 1.18
42 Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Am J Pathol 2005 1.18
43 Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution. Arterioscler Thromb Vasc Biol 2010 1.16
44 CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J Immunol 2004 1.16
45 Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Am J Pathol 2003 1.15
46 TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response. Eur J Immunol 2007 1.13
47 Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages. BMC Immunol 2010 1.13
48 Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. J Immunol 2004 1.12
49 Neutropenia impairs venous thrombosis resolution in the rat. J Vasc Surg 2003 1.12
50 Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun 2011 1.11
51 The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A. J Clin Invest 2011 1.10
52 Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol 2007 1.10
53 Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles. Clin Sci (Lond) 2003 1.08
54 Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice. Infect Immun 2008 1.07
55 Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization. Thromb Haemost 2006 1.07
56 Elevated chemokine responses are maintained in lungs after clearance of viral infection. J Virol 2002 1.07
57 Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes. PLoS One 2013 1.05
58 Toll-like receptors, Notch ligands, and cytokines drive the chronicity of lung inflammation. Proc Am Thorac Soc 2007 1.03
59 The chemokine CCL6 promotes innate immunity via immune cell activation and recruitment. J Immunol 2007 1.03
60 Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis. Thromb Haemost 2007 1.03
61 Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity. J Immunol 2007 1.02
62 CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice. J Immunol 2005 1.02
63 Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis. Immunol Res 2004 1.01
64 CCR4 participation in Th type 1 (mycobacterial) and Th type 2 (schistosomal) anamnestic pulmonary granulomatous responses. J Immunol 2006 1.00
65 Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma. PLoS Comput Biol 2010 1.00
66 Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am J Pathol 2006 0.99
67 Regulation of cockroach antigen-induced allergic airway hyperreactivity by the CXCR3 ligand CXCL9. J Immunol 2004 0.97
68 The critical role of Notch ligand Delta-like 1 in the pathogenesis of influenza A virus (H1N1) infection. PLoS Pathog 2011 0.97
69 Impaired CD4+ T-cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis. Eur J Immunol 2010 0.96
70 Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response. J Allergy Clin Immunol 2006 0.96
71 CCR4 is a key modulator of innate immune responses. J Immunol 2006 0.95
72 ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis. J Immunol 2009 0.95
73 Dendritic cells at the interface of innate and acquired immunity: the role for epigenetic changes. J Leukoc Biol 2007 0.95
74 Islet expression of M3 uncovers a key role for chemokines in the development and recruitment of diabetogenic cells in NOD mice. Diabetes 2007 0.95
75 Eosinophil recruitment in type-2 hypersensitivity pulmonary granulomas: source and contribution of monocyte chemotactic protein-3 (CCL7). Am J Pathol 2002 0.94
76 MT1-MMP regulates the PI3Kδ·Mi-2/NuRD-dependent control of macrophage immune function. Genes Dev 2012 0.94
77 IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis. PLoS One 2010 0.93
78 The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis. Eur J Pharmacol 2004 0.92
79 CC chemokine receptor 4 modulates Toll-like receptor 9-mediated innate immunity and signaling. Eur J Immunol 2008 0.92
80 Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production. Am J Physiol Regul Integr Comp Physiol 2006 0.92
81 Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Lab Invest 2003 0.91
82 Alterations in cytokine/chemokine expression during organ-to-organ communication established via acetaminophen-induced toxicity. Exp Mol Pathol 2003 0.91
83 Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation. PLoS One 2009 0.91
84 Triggering receptor expressed on myeloid cells-1 (TREM-1) modulates immune responses to Aspergillus fumigatus during fungal asthma in mice. Immunol Invest 2011 0.90
85 Contrasting roles for CXCR2 during experimental colitis. Exp Mol Pathol 2004 0.90
86 The linkage of innate and adaptive immune response during granulomatous development. Front Immunol 2013 0.89
87 Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile. J Leukoc Biol 2004 0.89
88 Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis. FASEB J 2005 0.89
89 The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice. Int Immunopharmacol 2011 0.88
90 Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. Transplantation 2002 0.88
91 Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. J Immunol 2005 0.88
92 MHV68 latency modulates the host immune response to influenza A virus. Inflammation 2013 0.87
93 Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis. Mediators Inflamm 2004 0.87
94 Helminth coinfection does not affect therapeutic effect of a DNA vaccine in mice harboring tuberculosis. PLoS Negl Trop Dis 2010 0.87
95 A multi-mineral natural product inhibits liver tumor formation in C57BL/6 mice. Biol Trace Elem Res 2012 0.87
96 Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol 2014 0.87
97 Notch system in the linkage of innate and adaptive immunity. J Leukoc Biol 2012 0.86
98 CC chemokine receptor 4 contributes to innate NK and chronic stage T helper cell recall responses during Mycobacterium bovis infection. Am J Pathol 2010 0.86
99 Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. PLoS One 2013 0.86
100 IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus. J Immunol 2012 0.86
101 TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung. Eur J Immunol 2008 0.86
102 CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis. J Immunol 2012 0.86
103 Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation. Am J Respir Crit Care Med 2009 0.86
104 Deep vein thrombosis resolution is not accelerated with increased neovascularization. J Vasc Surg 2004 0.86
105 Interleukin-13 fusion cytotoxin arrests Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Am J Pathol 2002 0.86
106 Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation. J Gen Virol 2007 0.85
107 Anti-CCL2 treatment inhibits Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neurovirol 2006 0.85
108 Lack of good correlation of serum CC-chemokine levels with human immunodeficiency virus-1 disease stage and response to treatment. J Lab Clin Med 2004 0.84
109 Chemokines and cytokines: axis and allies in asthma and allergy. Cytokine Growth Factor Rev 2003 0.84
110 Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion from human dermal microvascular endothelial cells. J Immunol 2002 0.84
111 Approaches to evaluation of fibrogenic pathways in surgical lung biopsy specimens. Methods Mol Med 2005 0.84
112 Dysregulated cytokine expression by CD4+ T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation. PLoS One 2011 0.84
113 Differential role of IFN-gamma-inducible protein 10 kDa in a cockroach antigen-induced model of allergic airway hyperreactivity: systemic versus local effects. J Immunol 2002 0.83
114 Eotaxin/CCL11 is a negative regulator of neutrophil recruitment in a murine model of endotoxemia. Exp Mol Pathol 2002 0.83
115 The chemokine receptor CCR6 is an important component of the innate immune response. Eur J Immunol 2007 0.83
116 Chemokines and their receptors in chronic pulmonary disease. Curr Drug Targets Inflamm Allergy 2005 0.83
117 Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1. PLoS One 2010 0.83
118 Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice. Br J Pharmacol 2005 0.83
119 STAT3-mediated IL-17 production by postseptic T cells exacerbates viral immunopathology of the lung. Shock 2012 0.82
120 Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin. J Vasc Surg 2006 0.82
121 Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus. Am J Physiol Lung Cell Mol Physiol 2002 0.81
122 Ketoprofen impairs immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2. Shock 2012 0.81
123 TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. J Immunol 2012 0.80
124 Pulmonary antifibrotic mechanisms aspirin-triggered lipoxin A(4) synthetic analog. Am J Respir Cell Mol Biol 2013 0.80
125 Understanding autoimmune disease: new targets for drug discovery. Drug Discov Today 2009 0.80
126 Therapeutic DNA vaccine reduces schistosoma mansoni-induced tissue damage through cytokine balance and decreased migration of myofibroblasts. Am J Pathol 2011 0.77
127 STAT5-induced lunatic fringe during Th2 development alters delta-like 4-mediated Th2 cytokine production in respiratory syncytial virus-exacerbated airway allergic disease. J Immunol 2013 0.77
128 CCR5 antagonists: the answer to inflammatory disease? Expert Opin Ther Pat 2006 0.77
129 Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. Crit Care Med 2016 0.77
130 Mice genetically lacking endothelial selectins are resistant to the lethality in septic peritonitis. Exp Mol Pathol 2002 0.76
131 Monocytes to functional dendritic cells is often a bridge too far for cancer therapy. Transl Res 2011 0.75
132 Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice. Am J Respir Cell Mol Biol 2014 0.75
133 Double-Stranded RNA Interacts With Toll-Like Receptor 3 in Driving the Acute Inflammatory Response Following Lung Contusion. Crit Care Med 2016 0.75
134 Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia. Crit Care Med 2016 0.75
135 The evolving role of the neutrophil in chemokine networks. Chem Immunol Allergy 2003 0.75
136 MDI 301 suppresses myeloid leukemia cell growth in vitro and in vivo without the toxicity associated with all-trans retinoic acid therapy. Anticancer Drugs 2015 0.75
137 Two strikes: limited NIH R55 and R56 retooling funds and abolishment of the A2 grant mechanism. FASEB J 2011 0.75