Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 3894214)

Published in PLoS Pathog on January 16, 2014

Authors

Kathryn Rozen-Gagnon1, Kenneth A Stapleford2, Vanesa Mongelli3, Hervé Blanc2, Anna-Bella Failloux4, Maria-Carla Saleh3, Marco Vignuzzi2

Author Affiliations

1: Institut Pasteur, Viral Populations and Pathogenesis, CNRS UMR 3569, Paris, France ; University Paris Diderot, Sorbonne Paris Cite, Cellule Pasteur, Paris, France.
2: Institut Pasteur, Viral Populations and Pathogenesis, CNRS UMR 3569, Paris, France.
3: Institut Pasteur, Viruses and RNA Interference, UMR 3569, Paris, France.
4: Institut Pasteur, Arboviruses and Insect Vectors, Paris, France.

Articles citing this

Chikungunya virus-vector interactions. Viruses (2014) 1.24

Analysis of Dengue Virus Genetic Diversity during Human and Mosquito Infection Reveals Genetic Constraints. PLoS Negl Trop Dis (2015) 1.09

Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases. J Virol (2014) 1.04

RNA virus population diversity, an optimum for maximal fitness and virulence. J Biol Chem (2014) 1.00

Favipiravir elicits antiviral mutagenesis during virus replication in vivo. Elife (2014) 0.93

Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus. J Virol (2014) 0.90

Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission. Viruses (2014) 0.87

Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes. PLoS Pathog (2015) 0.83

Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. J Virol (2015) 0.82

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion. J Virol (2015) 0.82

Low-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles. J Virol (2015) 0.78

Purification and Biochemical Characterisation of Rabbit Calicivirus RNA-Dependent RNA Polymerases and Identification of Non-Nucleoside Inhibitors. Viruses (2016) 0.77

Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes. PLoS Genet (2016) 0.76

Comparing competitive fitness of West Nile virus strains in avian and mosquito hosts. PLoS One (2015) 0.76

IFN-dependent and -independent reduction in West Nile virus infectivity in human dermal fibroblasts. Viruses (2014) 0.76

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens. J Virol (2016) 0.75

Next generation sequencing of DNA-launched Chikungunya vaccine virus. Virology (2016) 0.75

Dynamics of West Nile virus evolution in mosquito vectors. Curr Opin Virol (2016) 0.75

Chikungunya virus overcomes polyamine depletion by mutation of nsP1 and the opal stop codon to confer enhanced replication and fitness. J Virol (2017) 0.75

Population diversity and collective interactions during influenza virus replication and evolution. J Virol (2017) 0.75

Articles cited by this

The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39

Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature (2005) 6.78

Mutation rates among RNA viruses. Proc Natl Acad Sci U S A (1999) 6.37

Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol (2007) 6.16

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73

RNA virus populations as quasispecies. Curr Top Microbiol Immunol (1992) 5.42

RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci U S A (2001) 5.21

Genetic control of mutation rates in bacteriophageT4. Nature (1969) 4.06

Chikungunya virus in US travelers returning from India, 2006. Emerg Infect Dis (2007) 3.87

Viral mutation rates. J Virol (2010) 3.87

A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc Natl Acad Sci U S A (2003) 3.68

Mutagenic DNA polymerase. Biochem Biophys Res Commun (1965) 3.62

Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol (2010) 3.53

Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor. J Virol (1998) 3.51

Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice. PLoS Pathog (2005) 3.41

Quasispecies theory and the behavior of RNA viruses. PLoS Pathog (2010) 3.19

Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J Virol (1990) 3.11

Engineering attenuated virus vaccines by controlling replication fidelity. Nat Med (2008) 3.01

Viral quasispecies. Sci Am (1993) 2.91

Lethal mutagenesis of HIV with mutagenic nucleoside analogs. Proc Natl Acad Sci U S A (1999) 2.85

Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice. Virology (2000) 2.59

Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol (2004) 2.58

Genetic variation in West Nile virus from naturally infected mosquitoes and birds suggests quasispecies structure and strong purifying selection. J Gen Virol (2005) 2.58

Error thresholds and the constraints to RNA virus evolution. Trends Microbiol (2003) 2.42

Evolution of pig influenza viruses. Virology (1991) 2.40

Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem (2005) 2.40

Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription. J Virol (1993) 2.28

Theory of lethal mutagenesis for viruses. J Virol (2007) 2.20

RNAi targeting of West Nile virus in mosquito midguts promotes virus diversification. PLoS Pathog (2009) 2.13

Genetic diversity and slow rates of evolution in New World alphaviruses. Curr Top Microbiol Immunol (1992) 2.12

Arbovirus evolution in vivo is constrained by host alternation. Proc Natl Acad Sci U S A (2008) 2.04

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc Natl Acad Sci U S A (2010) 1.96

Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol (2003) 1.90

Deduced consensus sequence of Sindbis virus strain AR339: mutations contained in laboratory strains which affect cell culture and in vivo phenotypes. J Virol (1996) 1.88

Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications. Virus Res (2005) 1.81

Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proc Natl Acad Sci U S A (2011) 1.73

The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice. Virology (2006) 1.72

Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants. J Virol (1992) 1.61

Replication cycle of chikungunya: a re-emerging arbovirus. Virology (2009) 1.61

Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J Virol (2008) 1.60

Effect of alternating passage on adaptation of sindbis virus to vertebrate and invertebrate cells. J Virol (2005) 1.57

Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells. PLoS Pathog (2009) 1.56

Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection. J Biol Chem (1999) 1.53

Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures. J Virol (2010) 1.51

Fine-scale genetic variation and evolution of West Nile Virus in a transmission "hot spot" in suburban Chicago, USA. Virology (2008) 1.48

Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res (2005) 1.48

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus. PLoS Pathog (2013) 1.47

Role of the mutant spectrum in adaptation and replication of West Nile virus. J Gen Virol (2007) 1.46

Study of sequence variation of dengue type 3 virus in naturally infected mosquitoes and human hosts: implications for transmission and evolution. J Virol (2004) 1.37

Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. PLoS Pathog (2010) 1.34

The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket. J Virol (2009) 1.32

Coxsackievirus B3 mutator strains are attenuated in vivo. Proc Natl Acad Sci U S A (2012) 1.32

Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts. Cell Host Microbe (2011) 1.31

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching. Virology (2008) 1.29

The cost of replication fidelity in an RNA virus. Proc Natl Acad Sci U S A (2005) 1.28

The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase. Curr Opin Infect Dis (2001) 1.27

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nat Med (2012) 1.26

Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J Biol Chem (2007) 1.23

Characterization of mosquito-adapted West Nile virus. J Gen Virol (2008) 1.21

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. RNA Biol (2011) 1.18

Vector-borne transmission imposes a severe bottleneck on an RNA virus population. PLoS Pathog (2012) 1.16

West Nile virus experimental evolution in vivo and the trade-off hypothesis. PLoS Pathog (2011) 1.15

Catalytic core of alphavirus nonstructural protein nsP4 possesses terminal adenylyltransferase activity. J Virol (2006) 1.13

Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. J Virol (2012) 1.12

Factors shaping the adaptive landscape for arboviruses: implications for the emergence of disease. Future Microbiol (2013) 1.11

Beyond RNAi: antiviral defense strategies in Drosophila and mosquito. J Insect Physiol (2012) 1.10

Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution. J Virol (2011) 1.10

West Nile virus genetic diversity is maintained during transmission by Culex pipiens quinquefasciatus mosquitoes. PLoS One (2011) 1.08

Experimental passage of St. Louis encephalitis virus in vivo in mosquitoes and chickens reveals evolutionarily significant virus characteristics. PLoS One (2009) 1.06

A Polymerase mechanism-based strategy for viral attenuation and vaccine development. J Biol Chem (2012) 1.06

Adaptation of two flaviviruses results in differences in genetic heterogeneity and virus adaptability. J Gen Virol (2007) 1.05

ANDES: Statistical tools for the ANalyses of DEep Sequencing. BMC Res Notes (2010) 1.05

West Nile virus population genetics and evolution. Infect Genet Evol (2011) 1.02

Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin. J Virol (2010) 1.01

Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol (2008) 0.99

Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase. Virol J (2007) 0.99

BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). Virology (2013) 0.98

Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency. J Vis Exp (2011) 0.97

The cost of replication fidelity in human immunodeficiency virus type 1. Proc Biol Sci (2007) 0.96

Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection. J Virol (2008) 0.96

Mouse models for Chikungunya virus: deciphering immune mechanisms responsible for disease and pathology. Immunol Res (2012) 0.96

Cooperative interactions in the West Nile virus mutant swarm. BMC Evol Biol (2012) 0.95

O'nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3. PLoS Negl Trop Dis (2013) 0.95

NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. PLoS One (2011) 0.95

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation. Virol J (2013) 0.94

Virus mutators and antimutators: roles in evolution, pathogenesis and emergence. Trends Genet (2000) 0.92

Back to the future: revisiting HIV-1 lethal mutagenesis. Trends Microbiol (2012) 0.90

Ribavirin-resistant mutants of human enterovirus 71 express a high replication fidelity phenotype during growth in cell culture. J Virol (2012) 0.90

Quasispecies of dengue virus. Trop Med Health (2011) 0.89

Interrelationship between HIV-1 fitness and mutation rate. J Mol Biol (2012) 0.85