Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

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🔗 View Article (PMC 4086631)

Published in Sci Transl Med on January 29, 2014

Authors

Leonel Maldonado1, Jessica E Teague2, Matthew P Morrow3, Iveta Jotova4, T C Wu5, Chenguang Wang6, Cindy Desmarais7, Jean D Boyer8, Benjamin Tycko4, Harlan S Robins9, Rachael A Clark2, Cornelia L Trimble1,5,10

Author Affiliations

1: Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
2: Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA.
3: Inovio Pharmaceuticals Inc., 1787 Sentry Parkway West, Building 18, Suite 400, Blue Bell, PA 19422, USA.
4: Department of Pathology and Cell Biology and Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10025, USA.
5: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
6: Oncology Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
7: Adaptive Biotechnologies, 1551 Eastlake Avenue, Seattle, WA 98102, USA.
8: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
9: Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
10: Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

Associated clinical trials:

Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia | NCT00788164

A Study of VGX-3100 DNA Vaccine With Electroporation in Patients With Cervical Intraepithelial Neoplasia Grade 2/3 or 3 (HPV-003) | NCT01304524

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