Prediction of cancer drugs by chemical-chemical interactions.

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Published in PLoS One on February 03, 2014

Authors

Jing Lu1, Guohua Huang2, Hai-Peng Li3, Kai-Yan Feng4, Lei Chen5, Ming-Yue Zheng6, Yu-Dong Cai7

Author Affiliations

1: Department of Medicinal Chemistry, School of Pharmacy, Yantai University, Yantai, Shandong, People's Republic of China.
2: Institute of Systems Biology, Shanghai University, Shanghai, People's Republic of China ; Department of Mathematics, Shaoyang University, Shaoyang, Hunan, People's Republic of China.
3: CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
4: Beijing Genomics Institute, Shenzhen Beishan Industrial zone, Shenzhen, People's Republic of China.
5: College of Information Engineering, Shanghai Maritime University, Shanghai, People's Republic of China.
6: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai, People's Republic of China.
7: Institute of Systems Biology, Shanghai University, Shanghai, People's Republic of China.

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Phase II study of weekly mitoxantrone, 5-fluorouracil, and leucovorin in metastatic breast cancer. Breast Cancer Res Treat (1994) 0.76

[Etoposide (VP-16) in gynecologic malignancy]. Gan To Kagaku Ryoho (1996) 0.76

Comparative antitumor activities of 7-N-(p-hydroxyphenyl)mitomycin C (M-83) and mitomycin C. J Antibiot (Tokyo) (1983) 0.76

DNA damage by anthracycline drugs in human leukemia cells. Cancer Lett (1981) 0.76

Influence of fluoxymesterone on in vitro erythropoiesis affected by leukemic cells. Exp Hematol (1984) 0.76

[Successful treatment of advanced esophageal cancer with lymph node metastases by docetaxel, cisplatin and 5-FU followed by salvage lymphadenectomy--a case report]. Gan To Kagaku Ryoho (2010) 0.76

Childhood malignant tumors. Concurrent chemotherapy with dactinomycin and vincristine sulfate. JAMA (1966) 0.76