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1
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Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction.
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Circulation
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2004
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3.05
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2
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Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes.
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J Biol Chem
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2003
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2.27
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3
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N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.
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Am J Physiol Heart Circ Physiol
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2008
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1.94
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4
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Chemical biology of the sugar code.
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Chembiochem
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2004
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1.78
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5
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Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding.
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J Mol Biol
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2004
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1.57
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6
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From lectin structure to functional glycomics: principles of the sugar code.
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Trends Biochem Sci
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2011
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1.46
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7
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Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.
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J Cell Biol
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2005
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1.43
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8
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Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.
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J Biol Chem
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2005
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1.37
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9
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Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.
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Cancer Res
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2004
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1.36
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10
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Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes.
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Mol Cancer
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2010
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1.30
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11
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Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constants.
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Biochemistry
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2005
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1.29
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12
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Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages.
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Blood
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2009
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1.27
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13
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Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation.
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J Immunol
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2004
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1.23
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14
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The sugar code: functional lectinomics.
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Biochim Biophys Acta
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2002
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1.14
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15
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Quaternary solution structures of galectins-1, -3, and -7.
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Glycobiology
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2003
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1.13
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16
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Tumor galectinology: insights into the complex network of a family of endogenous lectins.
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Glycoconj J
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2004
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1.11
|
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17
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Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease.
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Thyroid
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2008
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1.10
|
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18
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Tumor-associated antigen 90K/Mac-2-binding protein: possible role in colon cancer.
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J Cell Biochem
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2006
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1.09
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19
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Photoderivatized polymer thin films at quartz crystal microbalance surfaces: sensors for carbohydrate-protein interactions.
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Anal Chem
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2007
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1.05
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20
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Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells.
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Traffic
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2009
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1.05
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21
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Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells.
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Oncogene
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2003
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1.05
|
|
22
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Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting.
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Cancer
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2003
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1.04
|
|
23
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Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization.
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Lung Cancer
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2003
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1.04
|
|
24
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Effects of polyvalency of glycotopes and natural modifications of human blood group ABH/Lewis sugars at the Galbeta1-terminated core saccharides on the binding of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N).
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Biochimie
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2004
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1.03
|
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25
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Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins.
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Biochemistry
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2003
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1.02
|
|
26
|
Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.
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Gastroenterology
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2008
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0.98
|
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27
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Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer.
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Ann Surg Oncol
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2006
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0.97
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28
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Localized fibrous tumors (LFTs) of the pleura: clinical data, asbestos burden, and syntactic structure analysis applied to newly defined angiogenic/growth-regulatory effectors.
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Pathol Res Pract
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2005
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0.96
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29
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Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to biomedically relevant lectins.
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J Am Chem Soc
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2013
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0.96
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30
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Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications.
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Mod Pathol
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2002
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0.95
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31
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Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.
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FEBS J
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2012
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0.95
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32
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Primary colorectal carcinomas and their intrapulmonary metastases: clinical, glyco-, immuno- and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival.
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APMIS
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2002
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0.95
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33
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Structure-activity profiles of complex biantennary glycans with core fucosylation and with/without additional alpha 2,3/alpha 2,6 sialylation: synthesis of neoglycoproteins and their properties in lectin assays, cell binding, and organ uptake.
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J Med Chem
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2002
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0.94
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34
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Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.
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FEBS J
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2010
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0.93
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35
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Galectin-3 - an emerging prognostic indicator in advanced head and neck carcinoma.
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Eur J Cancer
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2004
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0.90
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36
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Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region.
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Biochim Biophys Acta
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2010
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0.90
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37
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Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors.
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Org Biomol Chem
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2003
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0.89
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38
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Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells.
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FEBS J
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2014
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0.89
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39
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The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity.
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Anticancer Res
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2013
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0.88
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40
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Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration.
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Histochem Cell Biol
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2014
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0.88
|
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41
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Human galectins induce conversion of dermal fibroblasts into myofibroblasts and production of extracellular matrix: potential application in tissue engineering and wound repair.
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Cells Tissues Organs
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2011
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0.88
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42
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Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers.
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Angew Chem Int Ed Engl
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2014
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0.87
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43
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Galectin-3 upregulation during tumor progression in head and neck cancer.
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Laryngoscope
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2008
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0.87
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44
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Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking.
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Biol Chem
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2009
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0.87
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45
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Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by the human lectin galectin-1.
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Mol Vis
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2009
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0.87
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46
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Defining the glycophenotype of squamous epithelia using plant and mammalian lectins. Differentiation-dependent expression of alpha2,6- and alpha2,3-linked N-acetylneuraminic acid in squamous epithelia and carcinomas, and its differential effect on binding of the endogenous lectins galectins-1 and -3.
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APMIS
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2002
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0.87
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47
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Structural aspects of binding of α-linked digalactosides to human galectin-1.
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Glycobiology
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2011
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0.86
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48
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Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of galectin-1 and induction of poor prognosis factors.
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Int J Cancer
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2012
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0.86
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49
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Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins.
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Biochem Biophys Res Commun
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2008
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0.86
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50
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Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential.
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Histopathology
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2011
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0.86
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51
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Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population.
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Biochim Biophys Acta
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2012
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0.85
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52
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Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresia/luteolysis in contrast to pro-apoptotic galectins-1 and -7.
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Histochem Cell Biol
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2008
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0.85
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53
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Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
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Inflamm Res
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2009
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0.85
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54
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Dissecting molecular aspects of cell interactions using glycodendrimersomes with programmable glycan presentation and engineered human lectins.
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Angew Chem Int Ed Engl
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2015
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0.85
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55
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Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target.
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Expert Opin Ther Targets
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2013
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0.85
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56
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Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein.
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Arthritis Res Ther
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2013
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0.84
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57
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Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes.
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Cytometry A
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2008
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0.84
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58
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Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.
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Glycobiology
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2012
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0.84
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59
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Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7.
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Int J Oncol
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2009
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0.83
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60
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Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
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Glycobiology
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2009
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0.83
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61
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(1)H, (13)C, and (15)N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3.
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Biomol NMR Assign
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2014
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0.83
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62
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High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas.
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Int J Oncol
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2007
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0.83
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63
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Molecular recognition of the Thomsen-Friedenreich antigen-threonine conjugate by adhesion/growth regulatory galectin-3: nuclear magnetic resonance studies and molecular dynamics simulations.
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Biochemistry
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2012
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0.83
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64
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Versatile strategy for the synthesis of biotin-labelled glycans, their immobilization to establish a bioactive surface and interaction studies with a lectin on a biochip.
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Glycoconj J
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2008
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0.83
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65
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Fine specificity of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N).
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Biochem J
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2002
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0.82
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66
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The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage.
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Biochim Biophys Acta
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2009
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0.82
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67
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Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and x-ray scattering.
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Biophys J
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2003
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0.82
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68
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Phosphorylation of adhesion- and growth-regulatory human galectin-3 leads to the induction of axonal branching by local membrane L1 and ERM redistribution.
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J Cell Sci
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2010
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0.82
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69
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Phosphorylated human galectin-3: facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy.
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Biochim Biophys Acta
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2008
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0.82
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70
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Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus.
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Glycobiology
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2012
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0.82
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71
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Temperature dependence of ligand-protein complex formation as reflected by saturation transfer difference NMR experiments.
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Magn Reson Chem
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2007
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0.81
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72
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Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands.
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Bioorg Med Chem Lett
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2004
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0.81
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73
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Activity-structure correlations in divergent lectin evolution: fine specificity of chicken galectin CG-14 and computational analysis of flexible ligand docking for CG-14 and the closely related CG-16.
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Glycobiology
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2006
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0.81
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74
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Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas.
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Pathol Res Pract
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2003
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0.81
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75
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Carbohydrate chain of ganglioside GM1 as a ligand: identification of the binding strategies of three 15 mer peptides and their divergence from the binding modes of growth-regulatory galectin-1 and cholera toxin.
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Chemistry
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2005
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0.81
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76
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Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations.
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Graefes Arch Clin Exp Ophthalmol
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2012
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0.81
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77
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Synthesis and conformational analysis of (alpha-D-galactosyl)phenylmethane and alpha-,beta-difluoromethane analogues: interactions with the plant lectin viscumin.
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Chemistry
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2009
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0.81
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78
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Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions.
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J Am Chem Soc
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2014
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0.81
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79
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Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation.
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Glycobiology
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2006
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0.81
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80
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alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells.
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Glycobiology
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2005
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0.81
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81
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Galectin-loaded cells as a platform for the profiling of lectin specificity by fluorescent neoglycoconjugates: a case study on galectins-1 and -3 and the impact of assay setting.
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Glycobiology
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2008
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0.81
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82
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Neuronal Galectin-4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering.
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J Neurochem
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2013
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0.81
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83
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Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy.
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Histochem Cell Biol
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2011
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0.80
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84
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Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins.
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Biochemistry
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2009
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0.80
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85
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Hydrodynamic properties of human adhesion/growth-regulatory galectins studied by fluorescence correlation spectroscopy.
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Biophys J
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2010
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0.80
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86
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Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma.
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Anticancer Res
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2010
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0.80
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87
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Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence.
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Int J Biochem Cell Biol
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2006
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0.80
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88
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Monomer/dimer equilibrium of the AB-type lectin from mistletoe enables combination of toxin/agglutinin activities in one protein: analysis of native and citraconylated proteins by ultracentrifugation/gel filtration and cell biological consequences of dimer destabilization.
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Glycobiology
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2005
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0.80
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89
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Nuclear presence of adhesion-/growth-regulatory galectins in normal/malignant cells of squamous epithelial origin.
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Histochem Cell Biol
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2005
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0.80
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Down-regulation of the epidermal growth factor receptor by altering N-glycosylation: emerging role of β1,4-galactosyltransferases.
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Anticancer Res
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2012
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0.80
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91
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Towards functional glycomics by localization of binding sites for tissue lectins: lectin histochemical reactivity for galectins during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster.
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Histochem Cell Biol
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2006
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0.80
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92
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Glycan tagging to produce bioactive ligands for a surface plasmon resonance study via immobilization on different surfaces.
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Bioconjug Chem
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2009
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93
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Molecular recognition of complex-type biantennary N-glycans by protein receptors: a three-dimensional view on epitope selection by NMR.
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J Am Chem Soc
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2013
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0.80
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94
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Fluorinated carbohydrates as lectin ligands: versatile sensors in 19F-detected saturation transfer difference NMR spectroscopy.
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Chemistry
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2009
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0.80
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95
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Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.
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J Org Chem
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2009
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0.80
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Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin.
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Chemistry
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2014
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0.80
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97
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Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity.
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Org Biomol Chem
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2012
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0.80
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98
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The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity.
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Molecules
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2013
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0.80
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99
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Adhesion/growth-regulatory tissue lectin galectin-1 in relation to angiogenesis/lymphocyte infiltration and prognostic relevance of stromal up-regulation in laryngeal carcinomas.
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Anticancer Res
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Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.
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Acta Histochem Cytochem
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Alpha-O-linked glycopeptide mimetics: synthesis, conformation analysis, and interactions with viscumin, a galactoside-binding model lectin.
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Chemistry
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Ganglioside GM1/galectin-dependent growth regulation in human neuroblastoma cells: special properties of bivalent galectin-4 and significance of linker length for ligand selection.
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Neurochem Res
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2012
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AB-type lectin (toxin/agglutinin) from mistletoe: differences in affinity of the two galactoside-binding Trp/Tyr-sites and regulation of their functionality by monomer/dimer equilibrium.
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Glycobiology
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Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7.
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Anticancer Res
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105
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N-domain of human adhesion/growth-regulatory galectin-9: preference for distinct conformers and non-sialylated N-glycans and detection of ligand-induced structural changes in crystal and solution.
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Int J Biochem Cell Biol
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2010
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0.79
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106
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Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity.
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Glycobiology
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0.79
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Lectin-based drug design: combined strategy to identify lead compounds using STD NMR spectroscopy, solid-phase assays and cell binding for a plant toxin model.
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Synthetic polyamine BPA-C8 inhibits TGF-β1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro.
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Chembiochem
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Assessing the inhibitory potency of galectin ligands identified from combinatorial (glyco)peptide libraries using surface plasmon resonance spectroscopy.
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Anal Biochem
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1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin.
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Biomol NMR Assign
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2011
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0.78
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Galectin fingerprinting in Warthin's tumors: lectin-based approach to trace its origin?
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Histol Histopathol
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Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas.
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J Oral Pathol Med
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New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites.
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Biol Cell
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Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability.
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Solid phase measurements of antibody and lectin binding to xenogenic carbohydrate antigens.
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Clin Biochem
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Inhibitory potential of chemical substitutions at bioinspired sites of β-D-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins.
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Bioorg Med Chem
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Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting.
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J Mol Biol
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Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family.
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Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals.
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Biochem J
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Glycoconj J
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