Published in Biophys J on February 18, 2014
Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene (2015) 0.88
Atomic resolution probe for allostery in the regulatory thin filament. Proc Natl Acad Sci U S A (2016) 0.84
Regulatory domain of troponin moves dynamically during activation of cardiac muscle. J Mol Cell Cardiol (2014) 0.83
Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. J Muscle Res Cell Motil (2015) 0.83
Structural determinants of muscle thin filament cooperativity. Arch Biochem Biophys (2016) 0.81
A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J Mol Cell Cardiol (2015) 0.80
Conformation and Dynamics of the Troponin I C-Terminal Domain: Combining Single-Molecule and Computational Approaches for a Disordered Protein Region. J Am Chem Soc (2015) 0.79
An approach to improve the resolution of helical filaments with a large axial rise and flexible subunits. J Struct Biol (2015) 0.77
Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype. Front Physiol (2016) 0.76
Order-Disorder Transitions in the Cardiac Troponin Complex. J Mol Biol (2016) 0.76
Direct Measurements of Local Coupling between Myosin Molecules Are Consistent with a Model of Muscle Activation. PLoS Comput Biol (2015) 0.76
Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles. Biophys J (2017) 0.75
Relaxed and active thin filament structures; a new structural basis for the regulatory mechanism. J Struct Biol (2017) 0.75
The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation and Disease-Causing Mutations. Front Physiol (2016) 0.75
Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study. PLoS Comput Biol (2016) 0.75
The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin. Biophys J (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41
Regulation of contraction in striated muscle. Physiol Rev (2000) 9.40
Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament. Biophys J (1993) 5.66
A robust algorithm for the reconstruction of helical filaments using single-particle methods. Ultramicroscopy (2000) 5.01
Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form. Nature (2003) 4.71
SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat Protoc (2008) 4.60
The nature of the globular- to fibrous-actin transition. Nature (2009) 4.33
Structural role of tropomyosin in muscle regulation: analysis of the x-ray diffraction patterns from relaxed and contracting muscles. J Mol Biol (1973) 4.10
Steric-model for activation of muscle thin filaments. J Mol Biol (1997) 3.70
Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A (2005) 2.56
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. J Mol Biol (2000) 2.43
Ca(2+)-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction. Nature (1994) 2.34
Troponin T: genetics, properties and function. J Muscle Res Cell Motil (1998) 1.98
Image averaging of flexible fibrous macromolecules: the clathrin triskelion has an elastic proximal segment. J Struct Biol (1991) 1.94
An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol (2006) 1.89
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation. Biochem Biophys Res Commun (2007) 1.77
Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. Biophys J (2011) 1.76
The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation. J Mol Biol (2009) 1.75
Use of negative stain and single-particle image processing to explore dynamic properties of flexible macromolecules. J Struct Biol (2004) 1.71
Structural basis for the regulation of muscle contraction by troponin and tropomyosin. J Mol Biol (2008) 1.69
Single particle analysis of relaxed and activated muscle thin filaments. J Mol Biol (2005) 1.68
Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function. Adv Protein Chem (2005) 1.66
Troponin I: inhibitor or facilitator. Mol Cell Biochem (1999) 1.58
Structural basis for Ca2+-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin. J Mol Biol (2005) 1.49
Troponin and its interactions with tropomyosin. An electron microscope study. J Mol Biol (1982) 1.48
Structure of co-crystals of tropomyosin and troponin. Nature (1987) 1.47
Negative staining of myosin molecules. J Mol Biol (1985) 1.45
Image analysis of helical objects: the Brandeis Helical Package. J Struct Biol (1996) 1.44
Tropomyosin and the steric mechanism of muscle regulation. Adv Exp Med Biol (2008) 1.36
Molecular determination by electron microscopy of the actin filament end structure. J Mol Biol (2006) 1.32
Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophys J (2010) 1.22
Ca(2+)-induced switching of troponin and tropomyosin on actin filaments as revealed by electron cryo-microscopy. J Mol Biol (2001) 1.15
Localization of the two tropomyosin-binding sites of troponin T. Arch Biochem Biophys (2010) 1.13
Molecular arrangement of troponin-T in the thin filament. J Biochem (1979) 1.09
Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins. Proc Natl Acad Sci U S A (2002) 1.02
Chymotryptic subfragments of troponin T from rabbit skeletal muscle. Interaction with tropomyosin, troponin I and troponin C. J Biochem (1983) 0.95
Mapping subdomains in the C-terminal region of troponin I involved in its binding to troponin C and to thin filament. J Biol Chem (1999) 0.94
Single particle analysis of filamentous and highly elongated macromolecular assemblies. J Struct Biol (2004) 0.94
Troponin-tropomyosin interactions. Fluorescence studies of the binding of troponin, troponin T, and chymotryptic troponin T fragments to specifically labeled tropomyosin. Biochemistry (1984) 0.94
Structure and orientation of troponin in the thin filament. J Biol Chem (2009) 0.93
Conformation of the troponin core complex in the thin filaments of skeletal muscle during relaxation and active contraction. J Mol Biol (2012) 0.88
Isolation, electron microscopic imaging, and 3-D visualization of native cardiac thin myofilaments. J Struct Biol (1999) 0.88
Conformational changes of troponin C within the thin filaments detected by neutron scattering. J Mol Biol (2004) 0.88
Identification of a second binding region on rabbit skeletal troponin-T for alpha-tropomyosin. FEBS Lett (1981) 0.84
Nucleotide-dependent shape changes in the reverse direction motor, myosin VI. Biophys J (2010) 0.83
Structural studies of arthrin: monoubiquitinated actin. J Mol Biol (2004) 0.81
Mechanism of regulation of native cardiac muscle thin filaments by rigor cardiac myosin-S1 and calcium. J Biol Chem (2010) 0.81
An atomic model of the tropomyosin cable on F-actin. Biophys J (2014) 0.91
Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J (2017) 0.75
Switching Muscles On and Off in Steps: The McKillop-Geeves Three-State Model of Muscle Regulation. Biophys J (2017) 0.75