Current approaches to the treatment of metastatic brain tumours.

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Published in Nat Rev Clin Oncol on February 25, 2014

Authors

Taofeek K Owonikoko1, Jack Arbiser2, Amelia Zelnak1, Hui-Kuo G Shu3, Hyunsuk Shim3, Adam M Robin4, Steven N Kalkanis4, Timothy G Whitsett5, Bodour Salhia6, Nhan L Tran5, Timothy Ryken7, Michael K Moore8, Kathleen M Egan9, Jeffrey J Olson8

Author Affiliations

1: Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA.
2: Department of Dermatology, Atlanta Veterans Administration Medical Center, Emory University, Atlanta, GA 30322, USA.
3: Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA.
4: Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Boulevard, K-11, Detroit, MI 48202, USA.
5: Division of Cancer and Cell Biology, Translational Genomics Research Institute, 445 North 5th Street, Phoenix, AZ 85004, USA.
6: Division of Integrated Cancer Genomics, Translational Genomics Research Institute, 445 North 5th Street, Phoenix, AZ 85004, USA.
7: Iowa Spine and Brain Institute, 2710 St Francis Drive, Suite 110, Waterloo, IA 50702, USA.
8: Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA.
9: H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Associated clinical trials:

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases | NCT01494662

Lux-Breast 3; Afatinib Alone or in Combination With Vinorelbine in Patients With Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer Suffering From Brain Metastases | NCT01441596

Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid | NCT00241670

Carboplatin and Bevacizumab for Progressive Breast Cancer Brain Metastases | NCT01004172

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis | NCT01281696

Fluorescence-guided Surgery for Low- and High-grade Gliomas (BALANCE) | NCT01502280

Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery | NCT01372774

TPI 287 in Breast Cancer Metastatic to the Brain | NCT01332630

A Study of the Specificity and Sensitivity of 5- Aminolevulinic Acid (ALA) Fluorescence in Malignant Brain Tumors | NCT01128218

More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery | NCT01445691

Safety Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Tumors of the Brain (ALA) | NCT01116661

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme | NCT01575275

MEDICO-ECONOMIC EVALUATION OF SURGERY GUIDED BY FLUORESCENCE FOR THE OPTIMIZATION OF RESECTION OF GLIOBLASTOMAS (RESECT) | NCT01811121

Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas | NCT01502605

Study of Aminolevulinic Acid to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain | NCT00671710

A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors | NCT01351519

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