Molecular therapies in hepatocellular carcinoma: what can we target?

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🔗 View Article (PMC 4344119)

Published in Dig Dis Sci on February 27, 2014

Authors

Roberto Galuppo1, Dinesh Ramaiah, Oscar Moreno Ponte, Roberto Gedaly

Author Affiliations

1: Division of Transplantation Surgery, Department of Surgery, College of Medicine, University of Kentucky, 800 Rose Street, Room C453, Lexington, KY, 40536-0293, USA.

Associated clinical trials:

Global Study Looking at the Combination of RAD001 Plus Best Supportive Care (BSC) and Placebo Plus BSC to Treat Patients With Advanced Hepatocellular Carcinoma. (EVOLVE-1) | NCT01035229

Nexavar-Tarceva Combination Therapy for First Line Treatment of Patients Diagnosed With Hepatocellular Carcinoma (SEARCH) | NCT00901901

Dose Escalation Study of ARQ 197 in Combination With Sorafenib in Adult Patients With Advanced Solid Tumors | NCT00827177

Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer | NCT01010126

Bevacizumab and Erlotinib or Sorafenib as First-Line Therapy in Treating Patients With Advanced Liver Cancer | NCT00881751

Study of GC33 and Sorafenib in Combination in Advanced or Metastatic Liver Cancer (Hepatocellular Carcinoma) | NCT00976170

Sorafenib Tosylate With or Without Everolimus in Treating Patients With Localized, Unresectable, or Metastatic Liver Cancer | NCT01005199

4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma (Shelter) | NCT00943449

Sorafenib With BIIB022 in Hepatocellular Carcinoma (HCC) | NCT00956436

Phase II Combination of Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma | NCT01687673

Phase I/II Comparison of Efficacy and Safety of BIBF 1120 and Sorafenib in Patients With Advanced Hepatocellular Carcinoma | NCT01004003

Antiangiogenic Treatment of Hepatocellular Cancer With Bevacizumab and RAD001 | NCT00775073

A Study of the Effectiveness and Safety of AMG 386 and Sorafenib to Treat Advanced or Inoperable Hepatocellular Cancer | NCT00872014

A Study of IMC-A12 in Combination With Sorafenib in Patients With Advanced Cancer of the Liver | NCT00906373

Cixutumumab and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer | NCT01008566

CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer | NCT01033240

Temsirolimus + Sorafenib in Advanced Hepatocellular Carcinoma (HCC) | NCT01335074

Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma | NCT01258608

E7050 in Combination With Sorafenib Versus Sorafenib Alone as First Line Therapy in Patients With Hepatocellular Carcinoma | NCT01271504

Sirolimus and Bevacizumab in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery | NCT00467194

Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma | NCT01008917

Assessing BAY86-9766 Plus Sorafenib for the Treatment of Liver Cancer. (BASIL) | NCT01204177

Sorafenib and LBH589 in Hepatocellular Carcinoma (HCC) | NCT00823290

MEDI-573 in Combination With SOC in Unresectable or Metastatic HCC. (MEDI-573-1028) | NCT01498952

Sorafenib and TRC105 in Hepatocellular Cancer | NCT01306058

AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma | NCT01029418

Phase I Study of Perifosine + Sorafenib for Patients With Advanced Cancers | NCT00398814

A Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC) | NCT00712855

Bevacizumab and Erlotinib in Inoperable and Metastatic Hepatocellular Carcinoma | NCT00287222

NCT01013519

A Dose-Finding and Exploratory Study of RO5323441 in Combination With Sorafenib in Patients With Hepatocellular Carcinoma | NCT01308723

Bevacizumab and Sorafenib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Liver Cancer | NCT00867321

XIAP Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC) | NCT00882869

Study of Bavituximab and Sorafenib In Patients With Advanced Liver Cancer | NCT01264705

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