Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig.

PubWeight™: 0.76‹?›

🔗 View Article (PMC 3934941)

Published in PLoS One on February 25, 2014

Authors

Mandy Cook1, Bonnie J Bolkan1, Doris Kretzschmar1

Author Affiliations

1: Oregon Institute of Occupational Health Sciences, Oregon Health & Sciences University, Portland, Oregon, United States of America.

Articles cited by this

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30

AMPK in Health and Disease. Physiol Rev (2009) 6.38

FlyBase 101--the basics of navigating FlyBase. Nucleic Acids Res (2011) 5.46

A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14

Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell (2002) 3.83

Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature (2007) 3.71

The trip of the tip: understanding the growth cone machinery. Nat Rev Mol Cell Biol (2009) 3.38

Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci (1999) 3.25

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol (2006) 2.93

Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol (2006) 2.78

Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol (2005) 2.66

AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci (2001) 2.51

A higher control center of locomotor behavior in the Drosophila brain. J Neurosci (1993) 2.37

Ins and outs of ADF/cofilin activity and regulation. Eur J Cell Biol (2008) 2.34

Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth. Neuron (2000) 2.31

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol (2004) 2.14

Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. EMBO J (2005) 2.02

Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem (1999) 1.99

Membrane association and targeting of prenylated Ras-like GTPases. Cell Signal (1998) 1.96

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation. Cell Signal (2012) 1.78

Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science (2003) 1.77

Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts. J Neurosci (2006) 1.71

BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol (2007) 1.66

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr Biol (1999) 1.65

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. EMBO J (2002) 1.65

Isoprenoids: remarkable diversity of form and function. Lipids (2004) 1.47

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci (2006) 1.35

Isoprenoids control germ cell migration downstream of HMGCoA reductase. Dev Cell (2004) 1.34

The role of Rho GTPases and associated kinases in regulating neurite outgrowth. Int J Biochem Cell Biol (2002) 1.33

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am J Physiol Endocrinol Metab (2003) 1.32

Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila. Mol Biol Cell (2005) 1.24

p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol Chem (2008) 1.21

Cofilin-mediated neurodegeneration in Alzheimer's disease and other amyloidopathies. Mol Neurobiol (2007) 1.16

The steroid hormone 20-hydroxyecdysone enhances neurite growth of Drosophila mushroom body neurons isolated during metamorphosis. J Neurosci (1998) 1.14

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin. EMBO J (2007) 1.14

AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons. Neuroscientist (2009) 1.08

Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis. J Cell Sci (2007) 1.06

The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp Cell Res (2007) 0.99

ROCK, PAK, and Toll of synapses in Alzheimer's disease. Biochem Biophys Res Commun (2008) 0.85

Progressive neurodegeneration in Drosophila: a model system. J Neural Transm Suppl (2003) 0.83

Actin filaments-stabilizing and -bundling activities of cofilin-phosphatase Slingshot-1. Genes Cells (2007) 0.81

Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration. PLoS One (2012) 0.81

Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism. PLoS One (2012) 0.79