Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial.

PubWeight™: 3.69‹?› | Rank: Top 1%

🔗 View Article (PMC 4144040)

Published in Lancet Infect Dis on March 04, 2014

Authors

Beatriz Grinsztejn1, Mina C Hosseinipour2, Heather J Ribaudo3, Susan Swindells4, Joseph Eron5, Ying Q Chen6, Lei Wang6, San-San Ou6, Maija Anderson6, Marybeth McCauley7, Theresa Gamble8, Nagalingeshwaran Kumarasamy9, James G Hakim10, Johnstone Kumwenda11, Jose H S Pilotto12, Sheela V Godbole13, Suwat Chariyalertsak14, Marineide Gonçalves de Melo15, Kenneth H Mayer16, Susan H Eshleman17, Estelle Piwowar-Manning17, Joseph Makhema18, Lisa A Mills19, Ravindre Panchia20, Ian Sanne20, Joel Gallant17, Irving Hoffman5, Taha E Taha21, Karin Nielsen-Saines22, David Celentano21, Max Essex3, Diane Havlir23, Myron S Cohen24, HPTN 052-ACTG Study Team

Author Affiliations

1: Instituto de Pesquisa Clinica Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil.
2: University of North Carolina School of Medicine, Chapel Hill, NC, USA; UNC Project-Malawi, Lilongwe, Malawi.
3: Harvard School of Public Health, Boston, MA, USA.
4: University of Nebraska Medical Center, Omaha, NE, USA.
5: University of North Carolina School of Medicine, Chapel Hill, NC, USA.
6: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
7: FHI 360, Washington, DC, USA.
8: FHI 360, Durham, NC, USA.
9: Y R Gaitonade Center for AIDS Research and Education, Chennai, India.
10: University of Zimbabwe, Harare, Zimbabwe.
11: College of Medicine-Johns Hopkins Project, Lilongwe, Malawi.
12: Hospital Geral de Nova Iguacu and Laboratorio de AIDS e Imunologia Molecular-IOC/Fiocruz, Rio de Janeiro, Brazil.
13: National AIDS Research Institute (ICMR), Pune, India.
14: Research Institute for Health Sciences, Chiang Mai University, Chaing Mai, Thailand.
15: Hospital Nossa Senhora da Conceição, Porto Alegre RS, Brazil.
16: Fenway Institute, Boston, MA, USA.
17: Johns Hopkins University School of Medicine, Baltimore, MD, USA.
18: Botswana Harvard AIDS Institute, Gabarone, Botswana.
19: KEMRI-CDC, Kisumu, Kenya.
20: Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
21: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
22: David Geffen UCLA School of Medicine, Los Angeles, CA, USA.
23: University of California, San Francisco, CA, USA.
24: University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address: mscohen@med.unc.edu.

Associated clinical trials:

Preventing Sexual Transmission of HIV With Anti-HIV Drugs | NCT00074581

Articles citing this

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N Engl J Med (2015) 15.06

Antiretroviral Therapy for the Prevention of HIV-1 Transmission. N Engl J Med (2016) 3.71

End of the debate about antiretroviral treatment initiation. Lancet Infect Dis (2014) 2.45

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel. JAMA (2016) 2.23

AIDS incidence and AIDS-related mortality in British Columbia, Canada, between 1981 and 2013: a retrospective study. Lancet HIV (2015) 2.09

Comparative effectiveness of immediate antiretroviral therapy versus CD4-based initiation in HIV-positive individuals in high-income countries: observational cohort study. Lancet HIV (2015) 1.76

Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals. JAMA Intern Med (2015) 1.65

Knowledge, Beliefs and Practices Regarding Antiretroviral Medications for HIV Prevention: Results from a Survey of Healthcare Providers in New England. PLoS One (2015) 1.15

Reassessment of HIV-1 acute phase infectivity: accounting for heterogeneity and study design with simulated cohorts. PLoS Med (2015) 1.12

Challenges, successes and patterns of enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV Med (2015) 1.11

Editorial Commentary: Scaling Up Antiretroviral Preexposure Prophylaxis: Moving From Trials to Implementation. Clin Infect Dis (2015) 1.11

Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents 2014, Thailand. AIDS Res Ther (2015) 1.08

The 2015 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans. Infect Chemother (2015) 1.07

Successful antiretroviral therapy delivery and retention in care among asymptomatic individuals with high CD4+ T-cell counts above 350 cells/μl in rural Uganda. AIDS (2014) 1.03

Trends in AIDS Deaths, New Infections and ART Coverage in the Top 30 Countries with the Highest AIDS Mortality Burden; 1990-2013. PLoS One (2015) 1.02

Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples. J Acquir Immune Defic Syndr (2015) 1.01

Addressing social issues in a universal HIV test and treat intervention trial (ANRS 12249 TasP) in South Africa: methods for appraisal. BMC Public Health (2015) 1.00

TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis. J Int AIDS Soc (2016) 0.96

A Microperfusion and In-Bore Oxygenator System Designed for Magnetic Resonance Microscopy Studies on Living Tissue Explants. Sci Rep (2015) 0.92

Prevention strategies for blood-borne viruses-in the Era of vaccines, direct acting antivirals and antiretroviral therapy. Rev Med Virol (2016) 0.91

Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial. Lancet HIV (2016) 0.88

Optimization of Multicomponent Behavioral and Biobehavioral Interventions for the Prevention and Treatment of HIV/AIDS. AIDS Behav (2016) 0.88

Fertility Decision-Making Among Kenyan HIV-Serodiscordant Couples Who Recently Conceived: Implications for Safer Conception Planning. AIDS Patient Care STDS (2015) 0.88

HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials. AIDS Res Hum Retroviruses (2015) 0.87

High levels of heterogeneity in the HIV cascade of care across different population subgroups in British Columbia, Canada. PLoS One (2014) 0.87

The rise and fall of tuberculosis in Malawi: associations with HIV infection and antiretroviral therapy. Trop Med Int Health (2015) 0.87

Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial. J Acquir Immune Defic Syndr (2017) 0.87

Risk factors for delayed entrance into care after diagnosis among patients with late-stage HIV disease in southern Vietnam. PLoS One (2014) 0.86

Why START? Reflections that led to the conduct of this large long-term strategic HIV trial. HIV Med (2015) 0.86

Conditional Cash Transfers to Increase Retention in PMTCT Care, Antiretroviral Adherence, and Postpartum Virological Suppression: A Randomized Controlled Trial. J Acquir Immune Defic Syndr (2016) 0.84

Targeting HIV Prevention Based on Molecular Epidemiology Among Deeply Sampled Subnetworks of Men Who Have Sex With Men. Clin Infect Dis (2015) 0.84

Challenges in initiating antiretroviral therapy for all HIV-infected people regardless of CD4 cell count. Infect Dis Poverty (2016) 0.84

A scoping study to identify opportunities to advance the ethical implementation and scale-up of HIV treatment as prevention: priorities for empirical research. BMC Med Ethics (2014) 0.83

HIV Care Continuum Among Men Who Have Sex With Men and Persons Who Inject Drugs in India: Barriers to Successful Engagement. Clin Infect Dis (2015) 0.83

Improved survival in HIV treatment programmes in Asia. Antivir Ther (2016) 0.83

The Effect of Same-Day Observed Initiation of Antiretroviral Therapy on HIV Viral Load and Treatment Outcomes in a US Public Health Setting. J Acquir Immune Defic Syndr (2017) 0.83

Randomized trial of stopping or continuing ART among postpartum women with pre-ART CD4 ≥ 400 cells/mm3. PLoS One (2017) 0.83

Estimated Costs for Delivery of HIV Antiretroviral Therapy to Individuals with CD4+ T-Cell Counts >350 cells/uL in Rural Uganda. PLoS One (2015) 0.82

Tuberculosis incidence after 36 months' isoniazid prophylaxis in HIV-infected adults in Botswana: a posttrial observational analysis. AIDS (2015) 0.82

Australian gay and bisexual men's attitudes to HIV treatment as prevention in repeated, national surveys, 2011-2013. PLoS One (2014) 0.82

Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage. Curr Opin HIV AIDS (2015) 0.82

Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries. Infect Dis Poverty (2015) 0.81

Population-based surveillance of HIV drug resistance emerging on treatment and associated factors at sentinel antiretroviral therapy sites in Namibia. J Acquir Immune Defic Syndr (2015) 0.81

Medication-Taking Practices of Patients on Antiretroviral HIV Therapy: Control, Power, and Intentionality. AIDS Patient Care STDS (2015) 0.81

Combination antiretroviral therapy and cancer risk. Curr Opin HIV AIDS (2017) 0.80

Antiretroviral treatment regardless of CD4 count: the universal answer to a contextual question. AIDS Res Ther (2016) 0.80

Timing of Antiretroviral Treatment, Immunovirologic Status, and TB Risk: Implications for Testing and Treatment. J Acquir Immune Defic Syndr (2016) 0.80

A Successful Failure: Missing the MDG4 Target for Under-Five Mortality in South Africa. PLoS Med (2015) 0.80

Trends in AIDS-defining opportunistic illnesses incidence over 25 years in Rio de Janeiro, Brazil. PLoS One (2014) 0.79

Retention in Early Care at an HIV Outpatient Clinic in Rio de Janeiro, Brazil, 2000-2013. AIDS Behav (2016) 0.79

Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions. Expert Rev Anti Infect Ther (2014) 0.79

Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial. J Acquir Immune Defic Syndr (2016) 0.79

HIV care and treatment experiences among female sex workers living with HIV in sub-Saharan Africa: A systematic review. Afr J AIDS Res (2016) 0.79

Characteristics of HIV patients who missed their scheduled appointments. Rev Saude Publica (2015) 0.78

The role of family planning in achieving safe pregnancy for serodiscordant couples: commentary from the United States government's interagency task force on family planning and HIV service integration. J Int AIDS Soc (2017) 0.78

Antiretroviral Therapy to Prevent HIV Acquisition in Serodiscordant Couples in a Hyperendemic Community in Rural South Africa. Clin Infect Dis (2016) 0.78

Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH Project Accept (HPTN 043). J Acquir Immune Defic Syndr (2016) 0.78

Virologic outcomes in early antiretroviral treatment: HPTN 052. HIV Clin Trials (2017) 0.77

Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam. J Virus Erad (2016) 0.77

Point-of-care HIV tests done by peers, Brazil. Bull World Health Organ (2016) 0.77

Increased antiretroviral therapy prescription and HIV viral suppression among persons receiving clinical care for HIV infection. AIDS (2016) 0.77

Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs. Front Immunol (2015) 0.77

Demographic and HIV-specific characteristics of participants enrolled in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV Med (2015) 0.77

Determinants of time to antiretroviral treatment initiation and subsequent mortality on treatment in a cohort in rural northern Malawi. AIDS Res Ther (2016) 0.76

HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4(+) T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial. Retrovirology (2016) 0.76

Risk of Active Tuberculosis in HIV-Infected Patients in Taiwan with Free Access to HIV Care and a Positive T-Spot.TB Test. PLoS One (2015) 0.76

Predictors of opportunistic illnesses incidence in post combination antiretroviral therapy era in an urban cohort from Rio de Janeiro, Brazil. BMC Infect Dis (2016) 0.76

Methadone maintenance therapy and viral suppression among HIV-infected opioid users: The impacts of crack and injection cocaine use. Drug Alcohol Depend (2016) 0.76

Quality of life in persons living with HIV in Burkina Faso: a follow-up over 12 months. BMC Public Health (2015) 0.75

Use of peers to improve adherence to antiretroviral therapy: a global network meta-analysis. J Int AIDS Soc (2016) 0.75

Antiretroviral treatment initiation--authors' reply. Lancet Infect Dis (2014) 0.75

Scale-up of ART in Malawi has reduced case notification rates in HIV-positive and HIV-negative tuberculosis. Public Health Action (2016) 0.75

Beyond Risk Compensation: Clusters of Antiretroviral Treatment (ART) Users in Sexual Networks Can Modify the Impact of ART on HIV Incidence. PLoS One (2016) 0.75

HIV prevention & treatment - Reasons to rejoice & remain vigilant. Indian J Med Res (2015) 0.75

Implementation challenges and opportunities for HIV Treatment as Prevention (TasP) among young men in Vancouver, Canada: a qualitative study. BMC Public Health (2016) 0.75

Gaps in the Continuum of HIV Care: Long Pretreatment Waiting Time between HIV Diagnosis and Antiretroviral Therapy Initiation Leads to Poor Treatment Adherence and Outcomes. Biomed Res Int (2016) 0.75

New Biomedical Technologies and Strategies for Prevention of HIV and Other Sexually Transmitted Infections. J Sex Transm Dis (2016) 0.75

CD4 Cell Count: Declining Value for Antiretroviral Therapy Eligibility. Clin Infect Dis (2016) 0.75

"Making it personal": ideology, the arts, and shifting registers in health promotion. AIDS Care (2016) 0.75

Using the multiphase optimization strategy (MOST) to optimize an HIV care continuum intervention for vulnerable populations: a study protocol. BMC Public Health (2017) 0.75

Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy. AIDS (2016) 0.75

Status and methodology of publicly available national HIV care continua and 90-90-90 targets: A systematic review. PLoS Med (2017) 0.75

HIV care in Yangon, Myanmar; successes, challenges and implications for policy. AIDS Res Ther (2017) 0.75

Mycobacterium tuberculosis: 2014 Clinical trials in review. Can J Infect Dis Med Microbiol (2015) 0.75

Antiretroviral therapy: when to start. Infect Dis Clin North Am (2014) 0.75

Antiretroviral medication treatment for all HIV-infected individuals: a protocol using innovative multilevel methodologies to evaluate New York City's universal ART policy among problem substance users. BMC Health Serv Res (2016) 0.75

The importance of assessing self-reported HIV status in bio-behavioural surveys. Bull World Health Organ (2016) 0.75

Change of treatment guidelines and evolution of ART initiation in rural South Africa: data of a large HIV care and treatment programme. BMC Infect Dis (2015) 0.75

The Men Who Have Sex with Men HIV Care Cascade in Rio de Janeiro, Brazil. PLoS One (2016) 0.75

Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men. BMC Infect Dis (2015) 0.75

Antiretroviral therapy related adverse effects: Can sub-Saharan Africa cope with the new "test and treat" policy of the World Health Organization? Infect Dis Poverty (2017) 0.75

CD4 Variability in Malawi: Implications for Use of a CD4 Threshold of 500 Cells/mm(3) Versus Universal Eligibility for Antiretroviral Therapy. Open Forum Infect Dis (2016) 0.75

Australian health care providers' views on opt-out HIV testing. BMC Public Health (2015) 0.75

Delays in HIV diagnosis and associated factors among patients presenting with advanced disease at a tertiary care hospital in Beijing, China. PLoS One (2017) 0.75

PrEP in Italy: The time may be ripe but who's paying the bill? A nationwide survey on physicians' attitudes towards using antiretrovirals to prevent HIV infection. PLoS One (2017) 0.75

Are partners of HIV-infected people being tested for HIV? A mixed-methods research from Gujarat, India. Public Health Action (2017) 0.75

Mortality in patients with HIV-1 and tuberculosis co-infection in Rio de Janeiro, Brazil - associated factors and causes of death. BMC Infect Dis (2017) 0.75

Advanced Human Immunodeficiency Virus Disease at Diagnosis in Mozambique and Swaziland. Open Forum Infect Dis (2017) 0.75

Articles cited by this

Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med (2011) 69.36

Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet (2006) 31.79

Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med (2009) 19.90

Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet (2009) 14.01

Overadjustment bias and unnecessary adjustment in epidemiologic studies. Epidemiology (2009) 9.00

Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA (2012) 8.94

Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. N Engl J Med (2010) 8.72

Tuberculosis. Lancet (2011) 8.07

Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis (2008) 6.73

The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals. AIDS (2010) 5.85

When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Ann Intern Med (2011) 5.35

Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev (2010) 4.95

Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med (2013) 4.26

Identification of risk factors for extrapulmonary tuberculosis. Clin Infect Dis (2003) 3.55

Antiretroviral therapy for prevention of tuberculosis in adults with HIV: a systematic review and meta-analysis. PLoS Med (2012) 3.44

Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters. Arch Intern Med (2011) 2.99

Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count. AIDS (2007) 2.47

Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings. PLoS Med (2012) 2.40

Diagnosis of extrapulmonary tuberculosis by smear, culture, and PCR using universal sample processing technology. J Clin Microbiol (2005) 2.39

Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals. Ann Intern Med (2005) 2.26

British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012. HIV Med (2012) 2.24

Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV-infected, treatment-naive adults. Cochrane Database Syst Rev (2010) 1.94

AIDS and non-AIDS morbidity and mortality across the spectrum of CD4 cell counts in HIV-infected adults before starting antiretroviral therapy in Cote d'Ivoire. Clin Infect Dis (2012) 1.64

Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites. HIV Med (2010) 1.38

Meta-analysis: the association between HIV infection and extrapulmonary tuberculosis. Lung (2012) 1.31

The search for data on when to start treatment for HIV infection. J Infect Dis (2008) 1.31

Non-AIDS-defining events among HIV-1-infected adults receiving combination antiretroviral therapy in resource-replete versus resource-limited urban setting. AIDS (2011) 1.23