Published in Brain on March 12, 2014
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol (2017) 0.81
Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells. PLoS One (2015) 0.78
Candidate SNP Markers of Gender-Biased Autoimmune Complications of Monogenic Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. Front Immunol (2016) 0.76
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization. Front Aging Neurosci (2017) 0.76
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight (2017) 0.75
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics (1996) 11.71
Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell (1997) 4.44
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology (2010) 3.51
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest (1999) 3.21
Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med (2000) 3.15
CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med (2000) 3.09
Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J (1993) 2.69
The role of heparan sulphate in inflammation. Nat Rev Immunol (2006) 2.51
The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J Exp Med (2008) 2.15
The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol (2009) 2.12
The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol (2008) 2.08
Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends Immunol (2012) 2.01
Leukocyte extravasation: chemokine transport and presentation by the endothelium. Blood (2002) 1.92
Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium. Lab Invest (2005) 1.92
Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest (2001) 1.90
Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. J Immunol (2002) 1.88
The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci (2005) 1.74
Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood (2000) 1.65
CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. J Immunol (2006) 1.64
Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. Am J Pathol (2008) 1.58
The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J Clin Invest (1998) 1.49
The blood-brain barrier, chemokines and multiple sclerosis. Biochim Biophys Acta (2010) 1.40
Statistical analysis of data from studies on experimental autoimmune encephalomyelitis. J Neuroimmunol (2005) 1.35
Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol (2000) 1.33
Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegener Dis (2008) 1.31
The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. Biochem Biophys Res Commun (2004) 1.30
Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo. J Cereb Blood Flow Metab (2009) 1.27
Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol (2010) 1.24
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. J Neuroimmunol (2007) 1.23
CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis--an intravital microscopy study. J Neuroimmunol (2005) 1.18
Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann Neurol (1999) 1.17
Role for CXCR2 and CXCL1 on glia in multiple sclerosis. Glia (2006) 1.17
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol (2011) 1.16
A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions. Int Immunol (2003) 1.13
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node. Eur J Immunol (2008) 1.12
The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. J Leukoc Biol (1996) 1.11
Identification of cell types producing RANTES, MIP-1 alpha and MIP-1 beta in rat experimental autoimmune encephalomyelitis by in situ hybridization. J Neuroimmunol (1997) 1.09
Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis. Arch Neurol (2009) 1.07
Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J Neurovirol (1999) 1.05
The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels. J Neurosci (2001) 1.05
Binding of RANTES, MCP-1, MCP-3, and MIP-1alpha to cells in human skin. Am J Pathol (1998) 1.05
Transcellular transport of CCL2 across brain microvascular endothelial cells. J Neurochem (2008) 1.04
E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J Immunol (2007) 1.02
The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol (2012) 1.00
P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J Immunol (2005) 0.97
Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis. Neuroimmunomodulation (1998) 0.97
Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation. J Cereb Blood Flow Metab (2010) 0.96
Increased CXCL8 (IL-8) expression in Multiple Sclerosis. J Neuroimmunol (2004) 0.96
Enhanced expression of Duffy antigen in the lungs during suppurative pneumonia. J Histochem Cytochem (2003) 0.95
CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation (2012) 0.95
Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene. Genome Res (1997) 0.94
Gene and protein expression profiling of the microvascular compartment in experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice. Brain Pathol (2005) 0.91
Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells. PLoS One (2011) 0.80
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature (2005) 6.86
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol (2009) 5.97
Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem (2002) 5.40
CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol (2008) 5.35
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol (2007) 3.96
The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol (2012) 3.07
The chemokine receptor D6 limits the inflammatory response in vivo. Nat Immunol (2005) 2.98
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol (2008) 2.85
Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest (2002) 2.50
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J Exp Med (2007) 2.39
EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell (2002) 2.31
Pericytes and the pathogenesis of diabetic retinopathy. Diabetes (2002) 2.31
CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS One (2010) 2.28
Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis (2008) 2.26
Strategies to advance translational research into brain barriers. Lancet Neurol (2008) 2.16
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev (2013) 2.11
Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood (2009) 2.10
The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol (2008) 2.08
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J (2002) 2.05
Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol (2003) 1.99
Alpha4 integrins as therapeutic targets in autoimmune disease. N Engl J Med (2003) 1.90
Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat Immunol (2005) 1.90
Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res (2002) 1.86
Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci (2010) 1.85
CCR7 deficiency exacerbates injury in acute nephritis due to aberrant localization of regulatory T cells. J Am Soc Nephrol (2009) 1.79
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med (2008) 1.78
Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovasc Dis (2006) 1.75
Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med (2008) 1.74
VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. Circ Res (2008) 1.71
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol (2008) 1.61
The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. Mol Biol Cell (2004) 1.60
Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy. Diabetes (2004) 1.59
Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis. J Exp Med (2003) 1.58
IgM deposits on skin nerves in anti-myelin-associated glycoprotein neuropathy. Ann Neurol (2005) 1.56
Perivascular spaces and the two steps to neuroinflammation. J Neuropathol Exp Neurol (2008) 1.52
Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood (2006) 1.50
Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol (2008) 1.50
A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem (2002) 1.45
Mouse CD99 participates in T-cell recruitment into inflamed skin. Blood (2004) 1.42
Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis. J Neuropathol Exp Neurol (2006) 1.41
Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol (2004) 1.39
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem (2002) 1.38
Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med (2005) 1.37
Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. PLoS One (2008) 1.36
Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes (2008) 1.36
VE-PTP controls blood vessel development by balancing Tie-2 activity. J Cell Biol (2009) 1.32
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol (2004) 1.31
Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol (2003) 1.31
Immunologic privilege in the central nervous system and the blood-brain barrier. J Cereb Blood Flow Metab (2012) 1.30
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A (2009) 1.27
Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo. J Cereb Blood Flow Metab (2009) 1.27
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J (2007) 1.27
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm Res (2003) 1.26
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J Neurosci (2011) 1.25
Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain (2007) 1.24
Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol (2010) 1.24
Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains. Mol Cell Neurosci (2002) 1.22
Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol (2003) 1.21
Tight junctions in brain barriers during central nervous system inflammation. Antioxid Redox Signal (2011) 1.21
Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. Platelets (2004) 1.21
Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J (2003) 1.20
Chemokines on the move: control by the chemokine "interceptors" Duffy blood group antigen and D6. Semin Immunol (2003) 1.18
1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol (2009) 1.16
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol (2011) 1.16
T-cell trafficking in the central nervous system. Immunol Rev (2012) 1.15
In vivo analysis of uropod function during physiological T cell trafficking. J Immunol (2011) 1.15
Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS One (2009) 1.13
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node. Eur J Immunol (2008) 1.12
Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression. Thromb Haemost (2007) 1.11
Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J Immunol (2009) 1.11
Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood (2010) 1.11
Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro. Ann Neurol (2004) 1.10
Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res (2003) 1.09
Estrogen receptor α signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis. J Immunol (2011) 1.07
Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines. Hepatology (2008) 1.06
Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta Neuropathol (2009) 1.05
Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. J Comp Neurol (2011) 1.04
Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation. Blood (2012) 1.04
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am J Pathol (2007) 1.04
Coy decoy with a new ploy: interceptor controls the levels of homeostatic chemokines. Eur J Immunol (2006) 1.04
Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice. Exp Cell Res (2008) 1.03
The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis. Cerebrospinal Fluid Res (2005) 1.03
E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J Immunol (2007) 1.02
Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis. Brain Pathol (2008) 1.02
Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovasc Res (2011) 1.00